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Serum Calcium and Magnesium in Schizophrenia: Relationship to Clinical Phenomena and Neuroleptic Treatment

Published online by Cambridge University Press:  29 January 2018

Paul E. Alexander
Affiliation:
Section of Psychiatry and Human Behavior, Brown University, Division of Biology and Medicine; Veterans Administration Hospital, Providence, Rhode Island, 02908, USA
Daniel P. van Kammen
Affiliation:
Unit on Neuropsychopharmacology, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, 20014, USA
William E. Bunney Jr.
Affiliation:
Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, 20014, USA

Summary

Serum calcium and magnesium were studied in drug-free and neuroleptic-treated schizophrenic patients. Calcium and magnesium were not significantly different in 31 unmedicated schizophrenic patients compared with normal controls. Serum calcium was altered, however, in two subgroups: (1) Patients who remitted after neuroleptic withdrawal were significantly lower in calcium than those who did not remit; (2) catatonic schizophrenic patients appeared to have an increased calcium at the onset of catatonic stupor.

Patients treated with pimozide were found to have a significant decrease in both calcium and magnesium compared with their drug-free values. These same patients showed a similar decrease in both electrolytes during treatment with fluphenazine, a structurally different neuroleptic drug.

Type
Research Article
Copyright
Copyright © Royal College of Psychiatrists, 1978 

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References

Alexander, P. E., van Kammen, D. P. & Bunney, W. E. Jr. Serum calcium and magnesium in schizophrenia II. Relationship to extrapyramidal symptoms. Submitted for publication.Google Scholar
American Psychiatric Association, Committee on Nomenclature and Statistics (1968) Diagnostic and Statistical Manual of Mental Disorders (DSM-II). Second Edition. Washington: American Psychiatric Association.Google Scholar
Anden, N. E., Butcher, S. G., Corrodi, M., Fuxe, K. & Ungerstedt, U. (1970) Receptor activity and turnover of dopamine and noradrenaline after neuroleptics. European Journal of Pharmacology, 11, 303–14.Google Scholar
Bjorum, N. (1972) Electrolytes in blood in endogenous depression. Acta Psychiatrica Scandinavica, 48, 5968.Google Scholar
Brackenridge, C. J. & Jones, I. H. (1971) Relation of hypermagnesaemia to activity and neuroleptic drug therapy in schizophrenic states. Journal of Neurology, Neurosurgery and Psychiatry, 34, 195–9.Google Scholar
Bunney, W. E. Jr. & Hamburg, D. A. (1963) Methods for reliable longitudinal observation of behavior. Archives of General Psychiatry, 9, 280–94.CrossRefGoogle ScholarPubMed
Cade, J. F. (1964) A significant elevation of plasma magnesium levels in schizophrenia and depressive states. Medical Journal of Australia, 1, 195–6.Google Scholar
Carman, J. S. (1977) Personal communication.Google Scholar
Carman, J. S. Post, R. M., Goodwin, F. K. & Bunney, W. E. Jr. (1977a) Calcium and electroconvulsive therapy of severe depressive illness. Biological Psychiatry, 12, 517.Google ScholarPubMed
Carman, J. S. Post, R. M., Runkle, D. C., Bunney, W. E. Jr. & Wyatt, R. J. (1977b) Increased serum calcium and phosphorus with the ‘switch’ into manic or excited psychotic states. Submitted for publication.Google Scholar
Carman, J. S. & Wyatt, R. J. (1977) Alterations in cerebrospinal fluid and serum calcium with changes in psychiatric state. In Neuroregulators and Psychiatric Disorders (eds Usdin, E., Hamburg, D. A. and Barchas, J. D.). New York: New York, Oxford University Press.Google Scholar
Carney, M. W., Sheffield, B. F. & Sebastian, J. (1973) Serum magnesium, diagnosis, ECT and season. British Journal of Psychiatry, 122, 427–9.Google Scholar
Chugh, T. D., Dhingra, R. K., Gulati, R. C. & Bathla, J. C. (1973) Magnesium in schizophrenia. Indian Journal of Medical Research, 61, 9981001.Google ScholarPubMed
Chutkow, J. G. (1974) Metabolism of magnesium in central nervous system. Neurology, 24, 780–87.Google Scholar
Flach, F. F. (1964) Calcium metabolism in states of depression. British Journal of Psychiatry, 110, 588–93.Google Scholar
Frizel, D., Coppen, A. & Marks, V. (1969) Plasma magnesium and calcium in depression. British Journal of Psychiatry, 115, 1375–7.CrossRefGoogle ScholarPubMed
Gochman, N. & Givelber, H. (1970) Automated simultaneous microdetermination of calcium and magnesium by atomic absorption. Clinical Chemistry, 16, 229–34.Google Scholar
Gour, K. N. & Chaudhry, H. M. (1957) Study of calcium metabolism in electric convulsive therapy (ECT) in certain mental diseases. Journal of Mental Science, 193, 275–85.Google Scholar
Hammerschlag, R., Dravid, A. R. & Chiu, A. Y. (1975) Mechanism of axonal transport: a proposed role for calcium ions. Science, 188, 273–5.CrossRefGoogle ScholarPubMed
Hockaday, T. D. R., Keynes, W. & McKenzie, J. (1966) Catatonic stupor in elderly woman with hyperparathyroidism. British Medical Journal, i, 85–7.Google Scholar
Jimerson, D. C., Post, R. M., Carman, J. S., van Kammen, D. P., Wood, J. H., Goodwin, F. K. & Bunney, W. E. Jr. (1977) CSF calcium: clinical correlates in affective illness and schizophrenia. Submitted for publication.Google Scholar
Katzenelbogen, S. & Synder, R. (1943) Mineral constituents in blood serum and cells of schizophrenic patients. Archives of Neurology and Psychiatry, 50, 162–4.CrossRefGoogle Scholar
Knapp, S., Mandell, A. J. & Bullard, W. P. (1975) Calcium activation of brain tryptophan hydroxylase. Life Sciences, 16, 1583–94.Google Scholar
Lane, J. D. & Aprison, M. H. (1977) Calcium-dependent release of endogenous serotonin, dopamine and norepinephrine from nerve endings. Life Sciences, 20, 665–71.Google Scholar
Levy, W. B., Haycock, J. W. & Catman, C. W. (1974) Effect of polyvalent cations on stimulus-coupled secretion of (14C) γ—aminobutyric acid from isolated brain synaptosomes. Molecular Pharmacology, 10, 438–49.Google Scholar
Madeira, V. M. & Antunes-Madeira, M. C. (1973) Interaction of Ca+2 and Mg+2 with synaptic plasma membranes. Biochimica et Biophysica Acta, 323, 396407.Google Scholar
Marder, S. R., van Kammen, D. P., Murphy, D. L. & Bunney, W. E. Jr. (1977a) Platelet monoamine oxidase and drug-free recovery from psychosis. Presented at Annual Meeting of the American Psychiatric Association, Toronto, Canada, 5 May.Google Scholar
Marder, S. R., van Kammen, D. P., Docherty, J. P., Rayner, J. & Bunney, W. E. Jr. (1977b) Predicting drug-free remission from schizophrenic psychosis. Submitted for publication.Google Scholar
Matthysse, S. & Lipinski, J. (1975) Biochemical aspects of schizophrenia. Annual Review of Medicine, 26, 551–65.Google Scholar
Meltzer, H. Y. & Fang, V. S. (1976) The effect of neuroleptics on serum prolactin in schizophrenic patients. Archives of General Psychiatry, 33, 279–86.Google Scholar
Morgenroth, V. H., Boadle-Biber, M. C. & Roth, R. H. (1975) Activation of tyrosine hydroxylase from central noradrenergic neurons by calcium. Molecular Pharmacology, 11, 427–35.Google Scholar
Pandey, S. K., Devpura, J. C., Bedi, H. K. & Babel, C. S. (1973) An estimation of magnesium and calcium in serum and CSF in schizophrenia. Journal of the Association of Physicians of India, 21, 203–5.Google Scholar
Phillis, J. W. (1974) The role of calcium in the central effects of biogenic amines. Life Science, 14, 11891201.Google Scholar
Roberts, L. B. (1967) The normal ranges with statistical analysis for seventeen blood constituents. Clinica Chimica Acta, 16, 6978.Google Scholar
Robinson, C. J., Mahajan, K. K. & Horrobin, D. F. (1975) Some effects of prolactin on calcium metabolism. Journal of Endocrinology, 65, 27P.Google Scholar
Rubin, R. P. (1970) The role of calcium in the release of neurotransmitter substances and hormones. Pharmacological Reviews, 22, 389428.Google Scholar
Sachar, E. J., Gruen, P. H., Altman, N., Langer, G., Halpern, F. S. & Liefer, M. (1977) Prolactin responses to neuroleptic drugs: an approach to the study of brain dopamine blockade in humans. In Neuroregulators and Psychiatric Disorders, (eds Usdin, E., Hamburg, D. A. and Barchas, J. D.). New York: New York, Oxford University Press.Google Scholar
Seeman, P. (1972) The membrane actions of anesthetics and tranquilizers. Pharmacological Reviews, 24, 583655.Google ScholarPubMed
Simpson, G. M., Amuso, D., Blair, J. H. & Farkas, T. (1964) Phenothiazine-produced extra-pyramidal system disturbance. Archives of General Psychiatry, 10, 199208.Google Scholar
Snyder, S. H., Banerjee, S. P., Yamamura, H. I. & Greenberg, D. (1974) Drugs, neurotransmitters, and schizophrenia. Science, 184, 1243–53.Google Scholar
Speijer, N. (1950) Treatment of a periodical psychosis (degenerative psychosis) based upon haemotological and biochemical deviations from the normal. Folia Psychiatrica Neurologica et Neurochirurgica Neerlandica, 53, 718–26.Google Scholar
Spitzer, R. L., Endicott, J. & Robins, E. (1975) Clinical criteria for psychiatric diagnosis and DSM-II. American Journal of Psychiatry, 132, 1186–92.Google Scholar
Ueno, Y., Aoki, N., Yabuki, T. & Kuraishi, F. (1961) Electrolytes metabolism in blood and cerebrospinal fluid in psychoses. Folia Psychiatrica et Neurologka Japonica, 15, 304–26.Google Scholar
van Kammen, D. P. (1977) γ-aminobutyric acid (GABA) and the dopamine hypothesis of schizophrenia. American Journal of Psychiatry, 134, 138–43.Google ScholarPubMed
Wacker, W. E. & Parish, A. F. (1968) Magnesium metabolism. New England Journal of Medicine, 278, 658–63, 712–17, 772–76.Google Scholar
Walser, M. (1967) Magnesium metabolism. Ergebnisse der Physiologie, 59, 185296.Google Scholar
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