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Cognitive Functions in Manic-Depressives: Effects of Lithium and Physostigmine

Published online by Cambridge University Press:  29 January 2018

Rosemary Telford  and
Ernest P. Worrall
Rosemary Telford
Affiliation:
Southern General Hospital, Glasgow G51 4TF
Ernest P. Worrall
Affiliation:
University of Glasgow, Department of Psychological Medicine, Southern General Hospital, Glasgow G51 4TF
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Summary

Cognitive functions were investigated in seven manic-depressive patients while on lithium, after two weeks off lithium, and after a subcutaneous injection of physostigmine while on lithium. Test performance was unaffected by lithium, but after physostigmine the I.Q. score of a shortened version of the WAIS was significantly increased.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 133 , Issue 5 , November 1978 , pp. 424 - 428
Copyright
Copyright © Royal College of Psychiatrists, 1978 

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References

Aminoff, M. J. & Marshall, J. (1974) Treatment of Huntington's chorea with lithium carbonate. Lancet, i, 107–9.Google Scholar
Bech, P., Thomsen, J. & Rafaelsen, O. J. (1976) Long-term lithium treatment: effect on simulated driving and other psychological tests. European Journal of Clinical Pharmacology, 10, 331–5.CrossRefGoogle ScholarPubMed
Demers, R. G. & Heninger, G. R. (1971) Visual-motor performance during lithium treatment—a preliminary report. Journal of Clinical Pharmacology, 11, 274–9.Google ScholarPubMed
Drachman, D. A. & Leavitt, J. (1974) Human memory and the cholinergic system: a relationship to ageing? Archives of Neurology, 30, 113–21.Google Scholar
Gronwall, D. M. A. & Sampson, H. (1974) The Psychological Effects of Concussion. Auckland University/Oxford University Press, Auckland.Google Scholar
Friedman, M. J., Culver, C. M. & Ferrell, R. B. (1977) On the safety of long-term treatment with lithium. American Journal of Psychiatry, 134, 1123–6.Google ScholarPubMed
Judd, L. J., Hubbard, B., Janowsky, D. S., Huey, L. Y. & Takahashi, K. I. (1977) The effect of lithium carbonate on the cognitive functions of normal subjects. Archives of General Psychiatry, 34, 355–7.Google Scholar
Kusumo, K. S. & Vaughan, M. (1977) Effects of lithium salts on memory. British Journal of Psychiatry, 131, 453–7.Google Scholar
Linnoila, M., Saario, I. & Maki, M. (1974) Effect of treatment with diazepam or lithium and alcohol on psychomotor skills related to driving. European Journal of Clinical Pharmacology, 7, 337–42.Google Scholar
Marini, J. L. & Sheard, M. H. (1977) Antiaggressive effect of lithium ion in man. Acta Psychiatrica Scandinavica, 55, 269–86.Google Scholar
Muller-Oerlinghausen, B., Bauer, H., Girke, W., Kanowski, S. & Concalves, N. (1977) Impairment of vigilance and performance under lithium treatment. Studies in patients and normal volunteers. Pharmakopsychiatrie, Neuro-Psychopharmakologie, 10, 67–78.Google Scholar
Naylor, G. J., Smith, A., Boardman, L. J., Dick, D. A. T., Dick, E. G. & Dick, P. (1977) Lithium and erythrocyte membrane cation carrier studies in normal and manic-depressive subjects. Psychological Medicine, 7, 229–33.Google Scholar
Peters, B. H. & Levin, H. S. (1977) Memory enhancement after physostigmine treatment in the amnesic syndrome. Archives of Neurology, 34, 215–9.Google Scholar
Samples, J. R., Janowsky, D. S., Pechnick, R. & Judd, L. J. (1977) Lethal effects of physostigmine plus lithium in rats. Psychopharmacology, 52, 307–9.Google Scholar
Savage, R. D., Britton, P. G., Bolton, N. & Hall, E. H. (1973) Intellectual Functioning in the Aged. London: Methuen and Co. Ltd.Google Scholar
Slánská, J., Safratová, V., Vojtechovsky, M. & Skála, J. (1971) The effect of physostigmine on the perception and consolidation phase of memory and learning in alcoholics. Activitas Nervosa Superior (Praha), 13, 201–2.Google Scholar
Slánská, J., Vojtechovsky, M. & Votava, Z. (1972) The influence of physostigmine on individual phases of learning in man. Activitas Nervosa Superior (Praha), 14, 110–11.Google ScholarPubMed
Vizi, E. S., Illes, P., Ronai, A. & Knoll, J. (1972) The effect of lithium on acetylcholine release and synthesis. Neuropharmacology, 11, 521–30.Google Scholar
Worrall, E. P., Moody, J. P. & Naylor, G. J. (1975) Lithium in non-manic-depressives: antiaggressive effect and red blood cell lithium values. British Journal of Psychiatry, 126, 464–8.Google Scholar
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