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Pituitary Function and Psychosis: Cause Or Effect?

Published online by Cambridge University Press:  29 January 2018

Extract

The changes in pituitary gland function in mental illness are under intensive study. This is because the regulation of pituitary function by the brain involves monoamine neurotransmitters, and changes in hormonal secretion may thus reflect general fluctuations in monoamine activity in the brain. Characteristic patterns of change of diagnostic and therapeutic significance may also emerge. Thus, adrenocorticotrophic hormone secretion and adrenal corticosteroid activity are enhanced in depression, largely through the occurrence of additional secretory spikes of ACTH and the lack during the late evening or early morning of the normal fall in Cortisol secretion. Dexamethasone is less able to inhibit ACTH secretion in depression, while a fall in plasma glucose may less readily induce growth hormone secretion (Ettigi and Brown, 1977; Gruen, 1978). Nevertheless, there is no assurance that a monoamine neurotransmitter system concerned with pituitary function is affected in the same way as one influencing psychic outlook.

Type
Papers
Copyright
Copyright © Royal College of Psychiatrists, 1979 

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References

Assies, J., Schellekens, A. P. M. & Touber, J. L. (1978) Protein hormones in cerebrospinal fluid: evidence for retrograde transport of prolactin from the pituitary to the brain in man. Clinical Endocrinology, 8, 487–91.Google Scholar
Bergland, R. M., Davis, S. L. & Page, R. B. (1977) Pituitary secretes to brain. Experiments in sheep. Lancet, ii, 276–8.Google Scholar
Bergland, R. M. & Page, R. B. (1978) Can the pituitary secrete directly to the brain? (Affirmative anatomical evidence). Endocrinology, 102, 1325–38.Google Scholar
Donovan, B. T. (1978) The behavioural actions of the hypothalamic peptides: a review. Psychological Medicine, 8, 305–16.Google Scholar
Ettigi, P. G. & Brown, G. M. (1977) Psychoneuroendocrinology of affective disorder: an overview. American Journal of Psychiatry, 134, 493501.Google Scholar
Franks, S., Jacobs, H. S., Martin, N. & Nabarro, J. D. N. (1978) Hyperprolactinaemia and impotence. Clinical Endocrinology, 8, 277–87.Google Scholar
Gruen, P. H. (1978) Endocrine changes in psychiatric diseases. Medical Clinics of North America, 62, 285–96.Google Scholar
Heybach, J. P. & Vernikos-Danellis, J. (1978) The effect of pituitary-adrenal function in the modulation of pain sensitivity in the rat. Journal of Physiology, 283, 331–40.Google Scholar
Hyyppä, M. T., Liira, J. & Långvik, V.-A. (1978) Neuroendocrine aspects of neurology. Annals of Clinical Research, 10, 133–8.Google Scholar
Jacóuet, Y. F. (1978) Opiate effects after adrenocorticotropin or β-endorphin injection into the periaqueductal gray matter of rats. Science, 201, 1032–4.Google Scholar
Langer, G., Sachar, E. J., Halpern, F. S., Gruen, P. H. & Solomon, M. (1977) The prolactin response to neuroleptic drugs. A test of dopaminergic blockade: neuroendocrine studies in normal men. Journal of Clinical Endocrinology, 45, 9961002.Google Scholar
Luft, R. & Olivecrona, H. (1955) Hypophysectomy in man. Experiences in metastatic cancer of the breast. Cancer, 8, 261–70.Google Scholar
Nemeroff, C. B. & Prange, A. J. (1978) Peptides and psychoneuroendocrinology. Archives of General Psychiatry, 35, 9991010.Google Scholar
Oliver, C., Mical, R. S. & Porter, J. C. (1977) Hypothalamic-pituitary vasculature: evidence for retrograde blood flow in the pituitary stalk. Endocrinology, 101, 598604.Google Scholar
Schenk, G. K., Enders, P., Engelmeier, M.-P., Ewert, T., Herdemerten, S., Köhler, K.-H., Lodemann, E., Matz, D. & Pach, J. (1978) Application of the morphine antagonist naloxone in psychic disorders. Arzneimittel Forschung/Drug Research, 28 (II), 1274–7.Google ScholarPubMed
Szentágothai, J., Flerkó, B., Mess, B. & Halász, B. (1962) Hypothalamic control of the anterior pituitary. Akademiai Kiado, Budapest.Google Scholar
Walsh, R. J., Posner, B. I., Kopriwa, B. M. & Brawer, J. R. (1978) Prolactin binding sites in the rat brain. Science, 201, 1041–3.Google Scholar
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