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Clinical Significance of Plasma Drug and Prolactin Levels During Acute Chlorpromazine Treatment: A Replication Study

Published online by Cambridge University Press:  29 January 2018

Tamara Kolakowska ,
Michael Orr ,
Michael Gelder ,
Manuela Heggie ,
David Wiles  and
Michael Franklin
Tamara Kolakowska
Affiliation:
University of Oxford, Department of Psychiatry, Littlemore Hospital Research Unit, Littlemore Hospital, Oxford OX4 4XN
Michael Orr
Affiliation:
University of Oxford, Department of Psychiatry, Littlemore Hospital Research Unit, Littlemore Hospital, Oxford OX4 4XN
Michael Gelder
Affiliation:
University of Oxford, Department of Psychiatry, Littlemore Hospital Research Unit, Littlemore Hospital, Oxford OX4 4XN
Manuela Heggie
Affiliation:
University of Oxford, Department of Psychiatry, Littlemore Hospital Research Unit, Littlemore Hospital, Oxford OX4 4XN
David Wiles
Affiliation:
University of Oxford, Department of Psychiatry, Littlemore Hospital Research Unit, Littlemore Hospital, Oxford OX4 4XN
Michael Franklin
Affiliation:
University of Oxford, Department of Psychiatry, Littlemore Hospital Research Unit, Littlemore Hospital, Oxford OX4 4XN
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Summary

Nineteen patients with acute psychoses, the majority schizophrenics, were studied in the course of chlorpromazine (CPZ) treatment. Plasma levels of the drug, plasma prolactin (PRL), extrapyramidal side-effects (EPS) and changes in mental state were monitored weekly, as in our earlier study. The results confirm some of our previous findings: (a) plasma CPZ levels vary widely among patients and correlate poorly with daily doses of CPZ; (b) increased plasma PRL is associated with higher plasma CPZ levels and is more common among the patients who develop EPS; and (c) none of these three variables differ between groups of patients with good and poor treatment outcome. However we did not confirm our previous finding of a significant association between EPS and higher plasma CPZ, nor did we find that the ratio of CPZ-sulphoxide to CPZ differed between the improved patients and the rest.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 135 , Issue 4 , October 1979 , pp. 352 - 359
Copyright
Copyright © Royal College of Psychiatrists, 1979 

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