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Somnambulistic-like Episodes Secondary to Combined Lithium-Neuroleptic Treatment

Published online by Cambridge University Press:  29 January 2018

Dennis S. Charney ,
Anthony Kales ,
Constantin R. Soldatos  and
J. Craig Nelson
Dennis S. Charney
Affiliation:
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut
Anthony Kales
Affiliation:
Department of Psychiatry and Sleep Research and Treatment Center, Pennsylvania State University School of Medicine, Hershey, Pennsylvania
Constantin R. Soldatos
Affiliation:
Department of Psychiatry and Sleep Research and Treatment Center, Pennsylvania State University School of Medicine, Hershey, Pennsylvania
J. Craig Nelson
Affiliation:
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut
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Summary

Ten of 114 psychiatric patients undergoing combined lithium-neuroleptic treatment exhibited somnambulistic-like episodes. These episodes are differentiated from nocturnal wanderings and epileptic attacks during sleep; they occurred within two to three hours after sleep onset and were characterized by the patients appearing confused and walking about in a quiet, detached and clumsy manner. Generally, there was amnesia for the event. Since sleepwalking occurs out of slow wave sleep, the increase in slow wave sleep induced by lithium and certain neuroleptics may represent a neurophysiological mechanism responsible for these patients’ somnambulistic behaviour. The occurrence of grand mal seizures in two patients was probably unrelated to the somnambulistic-like episodes. However, persistence of the latter appears to be associated with drug-induced EEG irregularity.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 135 , Issue 5 , November 1979 , pp. 418 - 424
Copyright
Copyright © Royal College of Psychiatrists, 1979 

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