Hostname: page-component-8448b6f56d-jr42d Total loading time: 0 Render date: 2024-04-24T22:13:21.156Z Has data issue: false hasContentIssue false
  • English
  • Français

Lithium Restores Abnormal Platelet 5-HT Transport in Patients with Affective Disorders

Published online by Cambridge University Press:  29 January 2018

Alec Coppen ,
Cynthia Swade  and
Keith Wood
Alec Coppen
Affiliation:
Medical Research Council Neuropsychiatry Laboratory, West Park Hospital, Epsom, KT19 8PB, Surrey
Cynthia Swade
Affiliation:
Medical Research Council Neuropsychiatry Laboratory, West Park Hospital, Epsom, KT19 8PB, Surrey
Keith Wood
Affiliation:
Medical Research Council Neuropsychiatry Laboratory, West Park Hospital, Epsom, KT19 8PB, Surrey
Get access Rights & Permissions [Opens in a new window]

Summary

Kinetic analysis of the transport of 5-HT into the blood platelets of depressed patients and recovered depressive patients has shown that the rate of accumulation of 5-hydroxytryptamine (5-HT) is significantly decreased both before and after recovery from the illness. This abnormality is corrected by both short and long-term lithium treatment. As a corollary to these studies, the effect of lithium in vitro on 5-HT uptake has been studied and the results are opposite to those reported in vivo. These findings suggest that lithium acts indirectly, and possible mechanisms of its action are discussed.

Type
Papers
Information
The British Journal of Psychiatry , Volume 136 , Issue 3 , March 1980 , pp. 235 - 238
Copyright
Copyright © Royal College of Psychiatrists, 1980 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Coppen, A. (1967) The biochemistry of the affective disorders. British Journal of Psychiatry, 113, 1237–64.Google Scholar
Coppen, A., Noguera, R., Bailey, J., Burns, B. H., Swani, M. S., Hare, E. H., Gardner, R. & Maggs, R. (1971) Prophylactic lithium in affective disorders. Lancet, ii, 275–9.Google Scholar
Coppen, A., Turner, P., Rousell, A. R. & Padgham, C. (1976) 5-Hydroxytryptamine (5-HT) in the whole-blood of patients with depressive illness. Postgraduate Medical Journal, 52, 156–8.Google Scholar
Coppen, A., Swade, C. & Wood, K. (1978) Platelet 5-hydroxytryptamine accumulation in depressive illness. Clinica Chimica Acta, 87, 165–8.Google Scholar
Hamilton, M. (1960) A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry, 23, 56–62.Google Scholar
Hamlyn, J. M. & Duffy, T. (1978) Direct stimulation of human erythrocyte membrane (Na+ + K+) – Mg ATPase activity in vitro by physiological concentrations of d-aldosterone. Biochemical and Biophysical Research Communications, 84, 458–64.Google Scholar
Hesketh, J. E. (1976) Changes in membrane adenosine triphosphatases on administration of lithium salts in vivo. Biochemical Society Transactions, 4, 328–30.Google ScholarPubMed
Hesketh, J. E., Glen, A. I. M. & Reading, H. W. (1977) Membrane ATPase activities in depressive illness. Journal of Neurochemistry, 28, 1401–2.Google Scholar
Lineweaver, H. & Burk, D. (1934) The determination of enzyme dissociation constants. Journal of American Chemical Society, 56, 658–66.CrossRefGoogle Scholar
Sneddon, J. M. (1973) Blood platelets as a model for monoamine-containing neurones. Progress in Neurobiology, 1, 151–98.CrossRefGoogle Scholar
Stahl, S. M. (1977) The human platelet. A diagnostic and research tool for the study of biogenic amines in psychiatric and neurologic disorders. Archives of General Psychiatry, 34, 509–16.CrossRefGoogle Scholar
Transbøl, I., Christiansen, C., Baastrup, P. C., Damkjaer, M., Nielsen, M. D. & Griese, J. (1978) Endocrine effects of lithium. III. Hypermagnesaemia and activation of the renin-aldosterone system. Acta Endocrinologica, 88, 619–74.Google Scholar
Tuomisto, J. & Tukiainen, E. (1976) Decreased uptake of 5-hydroxytryptamine in blood platelets from depressed patients. Nature, 262, 596–9.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.