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Cyclic Amp Levels in Blood Cells from a Short-Cycle Manic-Depressive Subject

Published online by Cambridge University Press:  29 January 2018

Dorothy E. Buckley ,
Graham J. Naylor ,
David A. Stansfield  and
Richard A. Brown
Dorothy E. Buckley
Affiliation:
Department of Psychiatry/Biochemistry, University of Dundee, Royal Dundee Liff Hospital, Dundee DD2 5NF
Graham J. Naylor
Affiliation:
Department of Psychiatry, Ninewells Hospital and Medical School, Dundee DD1 9SY
David A. Stansfield
Affiliation:
Department of Biochemistry, University of Dundee
Richard A. Brown
Affiliation:
Department of Mathematics, University of Dundee
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Summary

Erythrocyte and leucocyte numbers and cyclic AMP content were monitored weekly in a mentally defective short-cycle manic-depressive woman. The erythrocyte count remained relatively constant but cyclic AMP content when manic was significantly higher than when depressed, and the mood and biochemical data appeared to have the same periodicity, with coincident peaks and troughs. Total leucocytes were related to mood, with peaks in the manic phase. Mononuclear cyclic AMP content varied without relation to manic or depressive phases.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 136 , Issue 6 , June 1980 , pp. 584 - 590
Copyright
Copyright © The Royal College of Psychiatrists 

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