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Schizophrenia on Paternal and Maternal Sides: An Analysis of Familial Factors

Published online by Cambridge University Press:  29 January 2018

Miron Baron
Miron Baron*
Affiliation:
Columbia University College of Physicians and Surgeons, and Department of Medical Genetics, New York State Psychiatric Institute, New York, N.Y. 10032, U.S.A.
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Summary

Slater's model of assessing distribution patterns of ancestral secondary cases in family trees was applied to pedigree data on schizophrenia. Eighteen schizophrenic probands with at least two ill second-degree relatives were available for study. The distribution of unilateral to bilateral pairs of affected relatives did not deviate significantly from that expected in polygenic inheritance. Contrasting pedigrees with family history of chronic schizophrenia with pedigrees loaded with ‘soft spectrum’ disorders, i.e., borderline schizophrenia, did not alter the consistency of the data with polygenic transmission.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 137 , Issue 6 , December 1980 , pp. 505 - 509
Copyright
Copyright © Royal College of Psychiatrists, 1980 

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