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HLA-A2 Antigen in Schizophrenic Patients with Reversed Cerebral Asymmetry

Published online by Cambridge University Press:  29 January 2018

Daniel J. Luchins ,
Daniel R. Weinberger ,
E. Fuller Torrey ,
Armead Johnson ,
Nicholas Rogentine  and
Richard Jed Wyatt
Daniel J. Luchins
Affiliation:
Adult Psychiatry Branch, National Institute of Mental Health, WAW Bldg., St Elizabeth's Hospital, Washington, D.C. 20032
Daniel R. Weinberger
Affiliation:
Adult Psychiatry Branch, National Institute of Mental Health, WAW Bldg., St Elizabeth's Hospital, Washington, D.C. 20032
E. Fuller Torrey
Affiliation:
Noyes Division, St Elizabeth's Hospital
Armead Johnson
Affiliation:
Division of Immunology, Department of Microbiology, Duke University of Medical School, Durham, North Carolina
Nicholas Rogentine
Affiliation:
Immunology Branch, National Cancer Institute, Bethesda, Maryland
Richard Jed Wyatt
Affiliation:
Adult Psychiatry Branch, National Institute of Mental Health, WAW Bldg., St Elizabeth's Hospital, Washington, D.C. 20032
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Summary

The frequency of HLA-A2 was examined in 32 black and 22 white schizophrenic patients separated into two groups according to whether they had normal or reversed cerebral hemispheric asymmetries as determined by computed tomography. The black patients with reversed asymmetry had a significantly greater frequency of HLA-A2 as compared to black patients with normal asymmetry and a black normal control group. There were no significant differences for any other A, B or C antigens. These findings also held when only the 22 black patients without evidence of brain atrophy were studied. The results for the white patients were in the same direction but did not reach statistical significance. These findings suggest that, at least for black schizophrenic patients, reversed cerebral asymmetry is associated with an increased frequency of HLA-A2.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 138 , Issue 3 , March 1981 , pp. 240 - 243
Copyright
Copyright © Royal College of Psychiatrists, 1981 

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References

Amos, D. B. & Pool, B. (1976) HLA Typing. Manual of Clinical Immunology (ed. N. R. Rose). American Society of Microbiology.Google Scholar
Hier, D. B. LeMay, M. & Rosenberger, P. B. (1978a) Autism: Association with reversed cerebral asymmetry. Neurology, 28, 348–349.Google Scholar
Hier, D. B. & Perlo, V. B. (1978b) Developmental dyslexia: Evidence for a subgroup with a reversal of cerebral asymmetry. Archives of Neurology, 35, 90–92.Google Scholar
Luchins, D. J. Weinberger, D. R. & Wyatt, R. J. (1979) Schizophrenia: Evidence for a subgroup with reversed cerebral asymmetry. Archives of General Psychiatry, 36, 1309–1311.CrossRefGoogle ScholarPubMed
Luchins, D. J. Torrey, E. F. Weinberger, D. R. Zalcman, S. DeLisi, L. Johnson, A. Rogentine, N. & Wyatt, R. J. (1980) HLA antigens in schizophrenia: Differences between patients with and without evidence of brain atrophy. British Journal of Psychiatry, 136, 243–248.Google Scholar
National Institute of Allergic and Infections Diseases (1976) NIAID Tissue Typing Techniques. DHEW Publications, NIM–76–545.Google Scholar
Rosenberger, P. B. Hier, D. B. & Epstein, A. (1978) Cerebral asymmetry in children with delayed speech. Child Neurology Society, Denver, Colorado.Google Scholar
Spitzer, R. L. Endicott, J. & Robins, E. (1977) Research Diagnostic Criteria (RDC) for a Selected Group of Functional Disorders. 3rd Ed. New York Psychiatric Institute.Google Scholar
Turner, W. J. (1979) Genetic markers for schizotaxia. Biological Psychiatry, 14, 177–206.Google ScholarPubMed
Weinberger, D. R. Torrey, E. F. Neophytides, A. N. & Wyatt, R. J. (1979a) Lateral cerebral ventricular enlargement in chronic schizophrenia. Archives of General Psychiatry, 36, 735–739.Google Scholar
Weinberger, D. R. Torrey, E. F. Neophytides, A. N. & Wyatt, R. J. (1979b) Structural abnormalities of the cerebral cortex in chronic schizophrenia. Archives of General Psychiatry, 36, 935–939.Google Scholar
Weinberger, D. R. Torrey, E. F. & Wyatt, R. J. (1979c) Cases of cerebellar atrophy in a group of chronic schizophrenic patients. Lancet, i, 718.CrossRefGoogle Scholar
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