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Immunological Indices in the Cerebrospinal Fluid of Patients with Presenile Dementia of the Alzheimer Type

Published online by Cambridge University Press:  29 January 2018

C. Jonker
Affiliation:
Neuropsychiatric Department, Valeriuskliniek, Valeriusplein 9, Amsterdam
P. Eikelenboom
Affiliation:
Department of Psychiatry, Vrije Universiteit, Valeriusplein 9, Amsterdam
P. Tavenier
Affiliation:
Laboratory of Clinical Chemistry, Valeriuskliniek, Valeriusplein 9, Amsterdam

Summary

In ten patients with presenile dementia of the Alzheimer type and in a control group the levels of the different immunoglobulins were determined in both serum and cerebrospinal fluid (CSF), and gel electrophoretic techniques used to determine possible oligoclonal bands in the gamma-globulin region. There is no indication that patients with Alzheimer disease produce immunoglobulins within the central nervous system.

Type
Research Article
Copyright
Copyright © The Royal College of Psychiatrists 

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