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Season of Birth in High and Low Genetic Risk Schizophrenics

Published online by Cambridge University Press:  29 January 2018

Eric Shur*
Affiliation:
Maudsley and Bethlem Royal Hospitals, London, SE5

Summary

Hypotheses which have been proposed to account for the unusual seasonal birth pattern observed in schizophrenic populations are discussed. These competing hypotheses were tested by retrospectively studying season of birth in 975 schizophrenics divided according to family history of psychiatric illness. Information was obtained from case notes, item sheets, and questionnaires sent to general practitioners. The results were inconclusive, but there was a trend for high genetic risk cases to be born less often in the first quarter of the year. Although no clear support could be provided for one or other season of birth hypothesis, it is tentatively suggested that a seasonal constitutional damage factor may be responsible for the excess of births described in schizophrenic populations in the early months of the year.

Type
Research Article
Copyright
Copyright © Royal College of Psychiatrists, 1982 

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References

Albrecht, P., Torrey, E. F., Boone, E., Hicks, J. T. & Daniel, N. (1980) Raised cytomegalovirus-antibody level in cerebrospinal fluid of schizophrenic patients. Lancet, 2, 769–72.Google Scholar
Buck, C., Simpson, H. & Wanklin, J. M. (1977) Survival of neices and nephews of schizophrenic patients. British Journal of Psychiatry, 130, 506–8.Google Scholar
Dalen, P. (1968) Month of birth and schizophrenia. Acta Psychiatrica Scandinavica, 203, 5560.Google Scholar
Dalen, P. (1974) Season of Birth. A Study of Schizophrenia and Other Mental Disorders. Amsterdam: North Holland/American Elsevier.Google Scholar
Hare, E. H. (1971) The Bethlem Royal Hospital and the Maudsley Hospital Triennial Statistical Report, 1967–1969. Google Scholar
Hare, E. H. (1975) Season of birth in schizophrenia and neurosis. American Journal of Psychiatry, 132(11), 1168–72.Google ScholarPubMed
Hare, E. H. (1976) The season of birth of siblings of psychiatric patients. British Journal of Psychiatry, 129, 4954.CrossRefGoogle ScholarPubMed
Hare, E. H., Price, J. & Slater, E. (1974) Mental disorder and season of birth: a national sample compared with the general population. British Journal of Psychiatry, 124, 81–6.CrossRefGoogle ScholarPubMed
Huxley, J., Mayr, E., Osmond, H. & Hoffer, A. (1964) Schizophrenia as a genetic morphism. Nature, 204, 220–1.Google Scholar
Jones, I. H. & Frei, D. (1979) Seasonal births in schizophrenia. A southern hemisphere study using matched pairs. Acta Psychiatrica Scandinavica, 59, 164–72.Google Scholar
Kety, S. S., Rosenthal, D., Wender, P. H., Schulsinger, F. & Jacobsen, B. (1975) In Genetic Research in Psychiatry (eds. Fieve, R. R., Rosenthal, D. and Brill, H.), pp 147–65. Baltimore and London: John Hopkins University Press.Google Scholar
Kinney, D. K. & Jacobsen, B. (1978) Environmental factors in schizophrenia: new adoption study evidence. In The Nature of Schizophrenia: New Approaches to Research and Treatment (ed. Wynne, L. C., Cromwell, R. L. and Matthysse, S.), pp 3851. New York: Wiley.Google Scholar
Lincoln, G. A. & Short, R. V. (1980) Seasonal breeding: Nature's contraceptive. In Recent Progress in Hormone Research (ed. Greep, R. O.), 36, 143.Google ScholarPubMed
Lipsedge, M. & Littlewood, R. (1979) Transcultural psychiatry. In Recent Advances in Clinical Psychiatry (ed. Granville-Grossman, K.), 3. Edinburgh: Churchill Livingstone.Google Scholar
McNeil, T., Kaij, L. & Dzierzykray-Rogalska, M. (1976) Season of birth among siblings of schizophrenics. Acta Psychiatrica Scandinavica, 54, 267–74.CrossRefGoogle ScholarPubMed
McNeil, T., Kaij, L. (1978) Obstetric factors in the development of schizophrenia. In The Nature of Schizophrenia (ed. Wynne, L. C., Cromwell, R. L. and Matthysse, S.). New York: Wiley.Google Scholar
Moskalenko, V. D. (1980) On the interpair differences in ontogenesis, premorbid state and severity of schizophrenia in twins. Zhurnal Neuropatologii I Psikhiatrii Imeni (Moskva), 80, 7883.Google Scholar
Ødegård, O. (1974) Season of birth in the general population and in patients with mental disorder in Norway. British Journal of Psychiatry, 125, 397405.Google Scholar
O'Hare, A., Walsh, W. & Torrey, F. (1980) Seasonality of schizophrenic births in Ireland. British Journal of Psychiatry, 137, 74–7.Google Scholar
Parker, G. & Balza, B. (1977) Season of birth and schizophrenia—an equatorial study. Acta Psychiatrica Scandinavica, 56, 143–6.CrossRefGoogle ScholarPubMed
Passominick, B. & Knobloch, H. (1966) Seasonal variation in complications in pregnancy. Obstetrics and Gynaecology, 12, 110–12.Google Scholar
Registrar General's Tables (1972) Statistical reviews for England and Wales for 1970. Vol. 2, HMSO.Google Scholar
Slater, E. & Cowie, V. (1971) The Genetics of Mental Disorders. London: Oxford University Press.Google Scholar
Torrey, E. F., Torrey, B. B. & Peterson, M. R. (1977) Seasonality of schizophrenic births in the United States. Archives of General Psychiatry, 34, 1065–70.Google Scholar
Tsuang, M. T., Winokur, G. & Crowe, R. R. (1980) Morbidity risks of schizophrenia and affective disorders among first-degree relatives of patients with schizophrenia, mania, depression and surgical conditions. British Journal of Psychiatry, 137, 497504.Google Scholar
Tyrrell, D. A. J., et al (1979) Possible virus in schizophrenia and some neurological disorders. Lancet, i, 839–41.Google Scholar
Van Horn, R. N. (1980) Seasonal reproductive patterns in primates. In Progress in Reproductive Biology (ed. Karger, S.), pp 181221. Basel.Google Scholar
Videbech, T., Weeke, A. & Dupont, A. (1974) Endogenous psychoses and season of birth. Acta Psychiatrica Scandinavica, 50, 202–18.Google Scholar
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