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Demethylation of C14 2,3,4-Trimethoxyphenylethylamine in Schizophrenics Before and After L-methionine Loading

Published online by Cambridge University Press:  29 January 2018

F. T. Antun  and
R. Kurkjian
F. T. Antun
Affiliation:
American University Medical Centre, PO Box 113-6044, Beirut, Lebanon
R. Kurkjian
Affiliation:
Brain Metabolism Unit, Department of Internal Medicine, American University Medical Centre, Beirut, Lebanon
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Summary

Demethylation was compared in acute and chronic schizophrenics and in non-schizophrenics by the administration of C14 labelled 2,3,4-trimethoxyphenylethylamine (TMPEA). The results did not show a significant difference in the urinary levels of the monodemethylated catabolites of TMPEA among any groups of patients. However, there was a significant decrease in demethylation in untreated chronic schizophrenics after ten days of L-methionine orally, whereas the non-schizophrenic group similarly given methionine did not change. This suggests the possibility of a biological weakness in schizophrenia.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 140 , Issue 6 , June 1982 , pp. 611 - 614
Copyright
Copyright © Royal College of Psychiatrists, 1982 

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