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Plasma Lithium Levels and Therapeutic Outcome in the Prophylaxis of Affective Disorders: A Retrospective Study

Published online by Cambridge University Press:  29 January 2018

S. P. Sashidharan ,
R. J. McGuire  and
A. I. M. Glen
S. P. Sashidharan
Affiliation:
MRC Unit for Epidemiological Studies in Psychiatry, Department of Psychiatry, Royal Edinburgh Hospital
R. J. McGuire
Affiliation:
Department of Psychology/Psychiatry, University of Edinburgh
A. I. M. Glen
Affiliation:
MRC Unit for Brain Metabolism and Royal Edinburgh Hospital. Current address: Consultant Psychiatrist, Craig Dunaine Hospital, Inverness
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Summary

Patients receiving prophylactic lithium therapy for primary affective disorder during a four year period were studied for recurrence of affective illness. Patients who had affective episodes during this period did not differ from those who remained well in age, sex or diagnosis. Those with a favourable outcome had spent significantly less time at serum lithium levels above 0.9 mmol/litre than those who had a recurrence of affective episodes.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 140 , Issue 6 , June 1982 , pp. 619 - 622
Copyright
Copyright © Royal College of Psychiatrists, 1982 

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References

Amdisen, A. (1980) Clinical and serum level monitoring in lithium therapy and lithium intoxication. In: Lithium: Controversies and Unresolved Issues, (eds. Cooper, T. B., Gershon, S. and Kline, N.). Amsterdam: Excerpta Medica Google Scholar
Coppen, A., Noguera, R., Bailey, J., Burns, B. H., Swani, M. S., Hare, E. H., Gardner, R. & Maggs, R. (1971) Prophylactic lithium in affective disorders. Controlled trial. Lancet, 2, 275–9.Google ScholarPubMed
Feighner, J. P., Robins, E., Guze, S. B., Woodruff, R. A., Winokur, G. & Munoz, R. (1972) Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry, 26, 57–63.Google Scholar
Gershon, S. (1968) Use of lithium salts in psychiatric disorders. Diseases of the Nervous System, 29, 51–5.Google ScholarPubMed
Grof, P. (1979) Some practical aspects of lithium treatment. Archives of General Psychiatry, 36, 891–3.CrossRefGoogle ScholarPubMed
Jerram, T. C. & McDonald, R. (1978) Plasma lithium control with particular reference to minimum effective levels. In: Lithium in Medical Practice, (eds. Johnson, F. N. and Johnson, S.), pp 407–13. Lancaster: MTP Press Google Scholar
Mendlewicz, J., Fieve, R. R. & Stallone, F. (1973) Relationship between the effectiveness of lithium therapy and family history. American Journal of Psychiatry, 130, 1011–13.CrossRefGoogle ScholarPubMed
Prien, R. F., Caffey, E. M. Jr. & Klett, C. J. (1972) Comparison of lithium carbonate and chlorpromazine in the treatment of mania. Archives of General Psychiatry, 26, 146–53.Google Scholar
Prien, R. F., Caffey, E. M. Jr. & Klett, C. J. (1972) Relationship between serum lithium level and clinical response in acute mania treated with lithium. British Journal of Psychiatry, 120, 409–14.CrossRefGoogle ScholarPubMed
Prien, R. F., Klett, C. J. & Caffey, E. M. Jr. (1973) Lithium carbonate and imipramine in prevention of affective episodes. Archives of General Psychiatry, 29, 420–5.CrossRefGoogle ScholarPubMed
Prien, R. F. & Caffey, E. M. Jr. (1976) Relationship between dosage and response to lithium prophylaxis in recurrent depression. American Journal of Psychiatry, 133, 567–70.Google Scholar
Schou, M. (1968) Lithium in psychiatric therapy and prophylaxis. Journal of Psychiatric Research, 6, 67–95.CrossRefGoogle ScholarPubMed
Schou, M. Amdisen, A. & Baastrup, P. C. (1971) The practical management of lithium treatment. British Journal of Hospital Medicine, 6, 53–60.Google Scholar
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