Hostname: page-component-8448b6f56d-tj2md Total loading time: 0 Render date: 2024-04-25T04:27:23.412Z Has data issue: false hasContentIssue false
  • English
  • Français

Elevated Motilin Levels in Patients Treated with Antidepressant and Neuroleptic Drugs

Published online by Cambridge University Press:  29 January 2018

J. M. Allen ,
N. D. Christofides ,
P. A. Cramer ,
J. Steinert  and
S. R. Bloom
J. M. Allen
Affiliation:
Hammersmith Hospital, Du Cane Road, London, W12
N. D. Christofides
Affiliation:
Department of Medicine, RPMS, London
P. A. Cramer
Affiliation:
St Bernards Hospital, Southall, Middlesex
J. Steinert
Affiliation:
St Bernard's Hospital, Southall, Middlesex
S. R. Bloom
Affiliation:
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, W12
Get access Rights & Permissions [Opens in a new window]

Summary

Constipation is a frequent effect of treatment with antidepressant and neuroleptic drugs as a result of interference with neuronal control of colonic muscular activity. Motilin, a circulating peptide, is involved in induction of myoelectric complexes in the colon. Significantly elevated circulating basal motilin levels were found in patients receiving tricyclic antidepressant drugs, mean 128±33 pmol/l (control 48±6 pmol/l) or neuroleptic therapy, mean 213±29 pmol/l (control 87±8 pmol/l).

Type
Research Article
Information
The British Journal of Psychiatry , Volume 141 , Issue 1 , July 1982 , pp. 27 - 29
Copyright
Copyright © The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Baldessarini, R. J. (1980) Drugs and the treatment of psychiatric disorders. In Pharmacological Basis of Therapeutics (eds. Goodman-Gilman, A., Goodman, L. S. and Gilman, A.). London: MacMillan.Google Scholar
Christofides, N. D. & Bloom, S. R. (1981) Motilin. In Gut Hormones (eds. Bloom, S. R. and Polak, J. M.). Edinburgh: Churchill Livingstone.Google Scholar
Christofides, N. D. Bryant, M. G., Ghatei, M. A. et al (1981) Molecular forms of motilin in the mammalian and human gut and human plasma. Gastroenterology, 80, 292–300.Google Scholar
Duthie, H. L. (1979) Large intestinal motility. In Scientific Basis for Gastroenterology (eds. Duthie, H. L. and Wormsley, K. G.). Edinburgh: Churchill Livingstone.Google Scholar
Goulston, E. (1976) Diverticular disease of the colon and megacolon. Incidence in a psychiatric centre compared with a teaching hospital. Medical Journal of Australia, 2, 863–4.Google Scholar
Itoh, Z. (1981) Effect of motilin on a gastrointestinal tract motility. In Gut Hormones (eds. Bloom, S. R. and Polak, J. M.). Edinburgh: Churchill Livingstone.Google Scholar
Lechin, F. & Van Der Dus, (1979) Effects of dopaminergic blocking agents on distal colon motility. Journal of Clinical Pharmacology, 19, 617–26.CrossRefGoogle ScholarPubMed
Lechin, F. Gomez, F., Fan Der Dus, B. & Lechin, E. (1980) Distal colon motility in schizophrenic patients. Journal of Clinical Pharmacology, 20, 459–64.Google Scholar
Smith, B., Grace, R. H. & Todd, I. R. (1977) Incidence in a psychiatric centre of organic constipation in adults. British Journal of Surgery, 64, 313–14.Google Scholar
Sriram, K., Schumer, W., Ehrenpreis, S. et al (1979) Phenothiazine effect on gastrointestinal tract function. American Journal of Surgery, 137, 87–91.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.