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Influence of Acetylator Phenotype on Antidepressant Effects of Phenelzine

Published online by Cambridge University Press:  29 January 2018

E. S. Paykel
Affiliation:
St George's Hospital Medical School, London SW17 0RE
P. S. West
Affiliation:
Department of Chemical Pathology, St George's Hospital Medical School; now Senior Biochemist, North Middlesex Hospital
P. R. Rowan
Affiliation:
St George's Hospital
R. R. Parker
Affiliation:
Trinity College, Dublin. (Formerly Research Fellow, St George's Hospital Medical School)

Summary

Acetylator phenotype, determined by blood levels after sulphadimidine, was related to outcome in a controlled trial of phenelzine in patients with depression and mixed anxiety depression. Slow acetylators showed more improvement and greater phenelzine-placebo differences than did fast acetylators, at two, four and six weeks. A tendency towards faster acetylation was observed in subjects with previous increased alcohol intake. Acetylator phenotype was not related to other symptom, diagnostic or history data.

Type
Research Article
Copyright
Copyright © Royal College of Psychiatrists, 1982 

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