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Abnormal Growth Hormone Response to TRH in Chronic Adolescent Schizophrenic Patients

Published online by Cambridge University Press:  29 January 2018

Ronit Weizman
Affiliation:
Geha Psychiatric Hospital, W. B. Schwartz Institute for Psychiatric Research, Beilinson Medical Center, Sackler School of Medicine, Tel-Aviv University, 49 100 Petah-Tiqva, Israel
Abraham Weizman
Affiliation:
Geha Psychiatric Hospital
Sam Tyano
Affiliation:
Geha Psychiatric Hospital
Irit Gil-Ad
Affiliation:
Institute of Paediatric and Adolescent Endocrinology, Beilinson Medical Center
Zvi Laron
Affiliation:
Institute of Pediatric and Adolescent Endocrinology, Beilinson Medical Center

Summary

There was a significant rise in the human growth hormone response to intravenous thyrotropin releasing hormone in 5 of 10 chronic schizophrenic adolescents maintained on antipsychotic agents, but in none of 10 age and sex matched control subjects. In 4 of the 5 patients with growth hormone rise there was a positive family history of schizophrenia, but such a family history was obtained in only one of the non-responding schizophrenics.

Type
Research Article
Copyright
Copyright © Royal College of Psychiatrists, 1982 

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