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The Causality of Depression in Schizophrenia

Published online by Cambridge University Press:  29 January 2018

Joe Galdi  and
Steven R. Hirsch
Joe Galdi
Affiliation:
Behavioral Neurology Program, New Hampshire Hospital, Concord, New Hampshire 03301, USA
Steven R. Hirsch
Affiliation:
Department of Psychiatry, Charing Cross Hospital Medical School, London W6
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Extract

The phenomenon of post-treatment depression in schizophrenia has become the subject of considerable controversy regarding its causality (Ananth and Chadirian, 1980; McGlashan and Carpenter, 1976a). But as the recent commentary by Hirsch (1982) emphasizes, the most controversial issue is focused on whether this depression is neuroleptic-induced. Hirsch himself refutes neuroleptic-induction on the basis of various uncontrolled data which seem ostensibly incompatible with this causality. Results indicating that pretreatment depressions appear in a high proportion of recently hospitalized schizophrenics, occur in drug-free patients, and frequently remit or decrease following neuroleptic therapy are cited as evidence contradicting neuroleptic-induction. Hirsch therefore proposes an alternative view: that this post-treatment depression is an integral, “revealed” aspect of the schizophrenia syndrome which arises from the same pathophysiological process (cf. McGlashan and Carpenter, 1976b).

Type
Discussion
Information
The British Journal of Psychiatry , Volume 142 , Issue 6 , June 1983 , pp. 621 - 625
Copyright
Copyright © 1983 The Royal College of Psychiatrists 

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