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Neuroleptics in the Short-Term Treatment of Anorexia Nervosa a Double-blind Placebo-Controlled Study with Sulpiride

Published online by Cambridge University Press:  29 January 2018

W. Vandereycken
W. Vandereycken*
Affiliation:
University Psychiatric Center St-Jozef, Leuvensesteenweg 517, B-3070 Kortenberg, Belgium
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Summary

There is a remarkable lack of controlled investigations about the usefulness of psychotropic drugs in anorexia nervosa despite the popular use of neuroleptics in these patients. Inspired by a previous study using pimozide, a double-blind placebo-controlled cross-over study with sulpiride was carried out in 18 female anorexia nervosa inpatients. No direct effect of sulpiride has been established with regard to behavioural and attitudinal characteristics as measured by behaviour observation scales as well as by two self-report questionnaires (Eating Attitudes Test, Body Attitudes Test). Regarding daily weight gain, sulpiride was on the whole superior to placebo, especially in the first treatment period of three weeks. In the cross-over analysis, however, this effect did not reach statistical significance.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 144 , Issue 3 , March 1984 , pp. 288 - 292
Copyright
Copyright © 1984 The Royal College of Psychiatrists 

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References

Barry, V. & Klawans, H. (1976) On the role of dopamine in the pathophysiology of anorexia nervosa. Journal of Neural Transmission, 38, 107–22.CrossRefGoogle ScholarPubMed
Bhanji, S. (1979) Anorexia nervosa: Physician's and psychiatrist's opinions and practice. Journal of Psychosomatic Research, 23, 7–11.CrossRefGoogle ScholarPubMed
Brown, B. W. (1980) The crossover experiment for clinical trials. Biometrics, 36, 60–72.Google Scholar
Chassan, J. B. (1979) Research Design in Clinical Psychology and Psychiatry (2nd ed.) New York: Irvington.Google Scholar
Dally, P. J. & Sargant, W. (1960) A new treatment of anorexia nervosa. British Medical Journal, 1, 1770–3.CrossRefGoogle ScholarPubMed
Dan, V. & Niang, I. (1973) Les effets du sulpiride dans les états de dénutrition en milieu hospitalier. Médecine de l'Afrique Noire, 20 (12), 2–11.Google Scholar
Desbuquois, G., Vialatte, J., Paupe, J. & Rossignol, C. (1969) Effets antiémétiques et eutrophiques du sulpiride chez l'enfant. Annates de Pédiatrie, 16, 460–4.Google Scholar
Garner, D. M. & Garfinkel, P. E. (1979) The Eating Attitudes Test: An index of the symptoms of anorexia nervosa. Psychological Medicine, 9, 273–9.CrossRefGoogle ScholarPubMed
Goldberg, S. C., Eckert, E. D., Halmi, K. A., Casper, R. C., Davis, J. M. & Roper, M. (1980) Effects of cyproheptadine on symptoms and attitudes in anorexia nervosa. Archives of General Psychiatry, 37, 1083.Google Scholar
Goldberg, S. C., Halmi, K. A., Eckert, E. D., Casper, R. C. & Davis, J. M. (1979) Cyproheptadine in anorexia nervosa. British Journal of Psychiatry, 134, 67–70.CrossRefGoogle ScholarPubMed
Gross, H. A., Ebert, M. H., Faden, V. B., Goldberg, S. C., Nee, L. E. & Kaye, W. H. (1981) A double-blind controlled trial of lithium carbonate in primary anorexia nervosa. Journal of Clinical Psychopharmacology, 1, 376–81.Google Scholar
Halmi, K. A., Eckert, E. & Falk, J. R. (1982) Cyproheptadine for anorexia nervosa. Lancet, 1, 1357–8.Google Scholar
Kellner, R., Uhlenhuth, E. H. & Glass, R. M. (1978) Clinical evaluation of antianxiety agents: Subject-own-control designs. In Psychopharmacology: A Generation of Progress (eds. Lipton, M. A., DiMascio, A. and Killam, K. F.). pp. 1391–400. New York: Raven Press.Google Scholar
Koch, G. G. (1972) The use of non-parametric methods in the statistical analysis of the two-period change-over design. Biometrics, 28, 577–84.Google Scholar
Lacey, J. H. & Crisp, A. H. (1980) Hunger, food intake and weight: The impact of clomipramine on a refeeding anorexia nervosa population. Postgraduate Medical Journal, 56 (Suppl. 1), 79–85.Google ScholarPubMed
Marchelli, E. A., Vaucheret, G. & Gómez de Martin Borado, H. (1973), Tratamiento de la anorexia nerviosa con sulpiride. Revista Argentina Psicofarmacologia, April–June, 14–17.Google Scholar
Martin, A., Masson, J. M., & Thouvenot, J. (1970) L'électrosplanchnographie dans les anorexies mentales et les dépressions. Premiers resultats. Semaine des Hôpitaux de Paris. 46, (29B), 54–60.Google Scholar
Moldofsky, H., Jeuniewic, N. & Garfinkel, P. E. (1977) Preliminary report on metoclopramide in anorexia nervosa. In Anorexia Nervosa (ed. Vigersky, R. A.) pp. 373–5. New York: Raven Press.Google Scholar
Piennes, M. G. (1977) L'intérêt du Dogmatil dans le traitement de l'anorexie mentale de l'enfant. Journal de Médecine et Chirurgie Pratique, 148, 201–3.Google Scholar
Pierloot, R., Vandereycken, W. & Verhaest, S. (1982) An inpatient treatment program for anorexia nervosa patients. Acta Psychiatrica Scandinavia, 66, 1–8.Google Scholar
Pope, H. G., Hudson, J. I., Jonas, J. M. & Yurgelum-Todd, D. (1983) Bulimia treated with imipramine: A placebo-controlled, double-blind study. American Journal of Psychiatry, 140, 554–8.Google ScholarPubMed
Rouger, M. E. (1979) A propos de l'effet orexigène du sulpiride. Journal de Médecine et Chirurgie Pratique, 150, 452–7.Google Scholar
Sabine, E. J., Yonace, A., Farrington, A. J., Barratt, K. H. & Wakeling, A. (1983) Bulimia nervosa: A placebo controlled double-blind therapeutic trial of mianserin. British Journal of Clinical Pharmacology, 15 (Suppl. 2), 195S–202S.Google Scholar
Slade, P. D. (1973) A short anorexic behaviour scale. British Journal of Psychiatry, 122, 83–5.Google Scholar
Spano, P. F., Trabucchi, M., Corsini, G. U. & Gessa, G. L. (eds.) (1979) Sulpiride and Other Benzamides, Milan: Italian Brain Research Foundation Press.Google Scholar
Stanley, M. & Rotrosen, J. (eds.) (1982) The Benzamides. Pharmacology, Neurobiology, and Clinical Aspects, New York: Raven Press.Google Scholar
Vandereycken, W. & Meermann, R. (1984) Anorexia Nervosa. A Clinician's Guide to Treatment. Berlin-New York: Walter de Gruyter (in press).Google Scholar
Vandereycken, W. & Pierloot, R. (1982) Pimozide combined with behavior therapy in the short-term treatment of anorexia nervosa. A double-blind placebo-controlled cross-over study. Acta Psychiatrica Scandinavia, 66, 445–50.Google Scholar
Vandereycken, W. & Pierloot, R. (1983) Combining drugs and behavior therapy in anorexia nervosa: A double-blind placebo/pimozide study. In Anorexia Nervosa: Recent Developments in Research (eds. Darby, P. L., Garfinkel, P. E., Garner, D. M. and Coscina, D. V.). New York: Alan R. Liss.Google Scholar
Vandereycken, W. & Vanderlinden, J. (1983) Denial of illness and the use of self-report measures in anorexia nervosa. International Journal of Eating Disorders, 2 n° 4, 101–7.Google Scholar
Vigersky, R. A. & Loriaux, D. L. (1977) The effects of cyproheptadine in anorexia nervosa: A double-blind trial. In Anorexia Nervosa (ed. Vigersky, R. A.). New York: Raven Press, 349–56.Google Scholar
Wermuth, B. M. Davis, K. L., Hollister, L. E. & Stunkard, A. J. (1977) Phenytoin treatment of the binge-eating syndrome. American Journal of Psychiatry, 134, 1249–53.Google Scholar
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