Hostname: page-component-8448b6f56d-sxzjt Total loading time: 0 Render date: 2024-04-23T09:00:30.062Z Has data issue: false hasContentIssue false
  • English
  • Français

Pipothiazine Palmitate in the Management of Aggressive Mentally Handicapped Patients

Published online by Cambridge University Press:  29 January 2018

D. M. Lynch ,
C. L. S. Eliatamby  and
A. A. Anderson
D. M. Lynch
Affiliation:
Turner Village Hospital, Colchester, Essex CO4 5JP
C. L. S. Eliatamby
Affiliation:
Essex Hall Hospital, Colchester, Essex CO1 1XE
A. A. Anderson
Affiliation:
Department of Clinical Research, May & Baker Ltd., Dagenham, Essex RM10 7XS
Get access Rights & Permissions [Opens in a new window]

Summary

The efficacy of intramuscular pipothiazine palmitate (PP) in the management of aggressive mentally handicapped patients was examined in a double-blind, placebo-controlled, cross-over study, in which 30 patients received each treatment for 13 weeks. A target symptom scale of aggressiveness (TSA) and a clinical global impression scale of efficacy were rated at monthly intervals, and an extra-pyramidal side-effects scale weekly. The patients showed marked improvement during treatment with PP, which was assessed as superior to placebo. Individual and total TSA scores were also reduced compared to placebo.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 146 , Issue 5 , May 1985 , pp. 525 - 529
Copyright
Copyright © 1985 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Albert, J. M., Elie, R. & Cooper, S. F. (1980) Long-term double-blind evaluation of pipotiazine palmitate and fluphcnazinc enanthatc. Current Therapuetic Research, 27, 897–907.Google Scholar
Albert, J. M., Elie, R. & Cooper, S. F. Clermont, A. & Langlois, Y. (1977) Efficacy of SCH-12679 in the management of aggressive mental retardates. Current Therapeutic Research. 21, 786–795.Google Scholar
Ayd, F. Jr. (1983) Depot pipotiazine: thirteen years later. International Drug Therapy Newsletter, 18, 5–8.Google Scholar
Badham, J. N., Bardon, L. M., Reeves, P. O. & Young, A. M. (1963) A trial of thioridazine in mental deficiency. British Journal of Psychiatry, 109, 408–410.Google Scholar
Brown-Thomsen, J. (1973) Review of clinical trials with pipotiazine. pipotiazine undecylenate and pipotiazine palmitate. Acta Psychiatrica Scandinavica, 241, 119–138 (suppl).CrossRefGoogle ScholarPubMed
Conover, W. J. (1980) Some methods based on ranks. In Practical Non-parametric Statistics, 2nd ed. Chichester: John Wiley Google Scholar
Craft, M. J. & Schiff, A. A. (1980) Psychiatric disturbance in mentally handicapped patients. British Journal of Psychiatry, 137, 250–255.Google Scholar
Guy, W. (1976) Clinical Global Impressions. In ECDEU Assessment Manual for Psychopharmacology, National Institute of Mental Health, Rockville. Maryland.Google Scholar
Hills, M. & Armitage, P. (1979) The two-period cross-over clinical trial. British Journal of Clincal Pharmcology, 8, 7–20.Google Scholar
Hunter, H. & Stephenson, G. M. (1963) Chlorpromazine and trifluoperazine in the treatment of behavioural abnormalities in the severely subnormal child. British Journal of Psychiatry, 109, 411–417.CrossRefGoogle ScholarPubMed
Itil, T. M. & Wadud, A. (1975) Treatment of human aggression with major tranquillizers, antidepressants and newer psychotropic drugs. Journal of Nervous and Mental Disease, 160, 83–99.Google Scholar
Karland, A. A. & Goldberg, J. B. (1970) Piperacetazine (Ouide) in the management of behavioural disorders in mildly handicapped institutionalized boys. Current Therapeutic Research, 12, 798–804.Google Scholar
Kinnel, H. G. (1977) Depot tranquillizers for disturbed behaviour. British Medical Journal, ii, 578.CrossRefGoogle Scholar
MaCdonald, A. J. D. (1981) Psychiatric disturbance in mentally handicapped patients (Correspondence). British Journal of Psychiatry, 138, 83–84.Google Scholar
Perinpanayagam, P. J. & Haig, R. A. (1977) Use of depot tranquillizers in disturbed adolescent girls. British Medical Journal, i, 835–836.Google Scholar
Rajotte, P., Giard, N. & Tetreault, L. (1966) A controlled trial of propericiazine and chlorpromazine in “behaviour disorders”. Current Therapeutic Research, 8, 166–174.Google Scholar
Reid, A. H. (1972) Psychosis in adult mental defectives II. Schizophrenic and paranoid psychoses. British Journal of Psychiatry, 120, 213–218.Google Scholar
Schlosberg, A. & Shadmi, M. (1978) A comparative controlled study of two long-acting phenothiazines. Pipotiazine palmitate and fluphenazinc decanoate. Current Therapeutic Research, 23, 642–653.Google Scholar
Singh, A. N. & Saxena, B. (1979) A comparative study of prolonged action (depot) neuroleptics: Pipotiazine palmitate versus fluphcnazinc enanthate in chronic schizophrenic patients. Current Therapeutic Research, 25, 121–132.Google Scholar
Ucer, E. & Kreger, K. C. (1969) A double-blind study comparing haloperidol and thioridazine in emotionally disturbed, mentally handicapped children. Current Therapeutic Research, 11, 278–283.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.