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Serum and CSF Antibody Titres to Seven Common Viruses in Schizophrenic Patients

Published online by Cambridge University Press:  29 January 2018

D. J. King*
Affiliation:
Department of Therapeutics and Pharmacology, The Queen's University of Belfast, The Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, and Holywell Hospital, Antrim, Northern Ireland
S. J. Cooper
Affiliation:
Department of Biochemistry, Queen's University of Belfast, Belfast, Northern Ireland
J. A. P. Earle
Affiliation:
Department of Biochemistry, Queen's University of Belfast, Belfast, Northern Ireland
S. J. Martin
Affiliation:
Department of Biochemistry, Queen's University of Belfast, Belfast, Northern Ireland
N. V. McFerran
Affiliation:
Department of Biochemistry, Queen's University of Belfast, Belfast, Northern Ireland
G. B. Wisdom
Affiliation:
Department of Biochemistry, Queen's University of Belfast, Belfast, Northern Ireland
*
Correspondence

Summary

CSF and matched serum antibody titres to seven common viruses were measured in 20 chronic schizophrenic patients, and 17 of these were age and sex-matched with orthopaedic controls. CT scans were carried out in patients and age and sex-matched radiological controls. There was a trend for CSF viral antibody titres (except CMV, HSV and VZV) to be decreased in the patients compared to controls, statistically significant for mumps and IgG. The CSF/serum ratios showed a reduction in the patients, compared to controls, statistically significant for measles and rubella as well as mumps and IgG. Cerebral ventricular size was significantly increased in the patients compared to controls, but did not correlate with any of the antibody data. These findings suggest that there is a reduced immune response to certain common viruses in the CNS of schizophrenic patients, but possible effects of institutionalisation or current medication could only be adequately excluded by further prospective studies.

Type
Papers
Copyright
Copyright © 1985 The Royal College of Psychiatrists 

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References

Albrecht, P., Torrey, E. F., Boone, E., Hicks, J. T. & Daniel, N. (1980) Raised cytomegalovirus—antibody level in cerebrospinal fluid of schizophrenic patients. Lancet ii, 769772.Google Scholar
American Psychiatric Association (1980). Diagnostic and Statistical Manual of Mental Disorders. 3rd Edition. Washington, D.C. Google Scholar
Crow, T. J. (1980) Molecular pathology of schizophrenia: more than one disease process? British Medical Journal, 280, 6668.Google Scholar
Delisi, L. E., Weinberger, D. R., Potkin, S., Neckers, L. M., Shiling, D. J. & Wyatt, R. J. (1981) Quantitative determination of immunoglobulins in CSF and plasma of chronic schizophrenic patients. British Journal of Psychiatry, 139, 513518.CrossRefGoogle ScholarPubMed
Donnelly, E. F., Weinberger, D. R., Waldman, I. N. & Wyatt, R. J. (1980) Cognitive impairment associated with morphological brain abnormalities on computed tomography in chronic schizophrenic patients. Journal of Nervous and Mental Disease, 168, 305308.Google Scholar
Earle, J. A. P., McFerran, N. V. & Wisdom, G. B. (1984) Enzyme-linked immuno-sorbent assay (ELISA) of antibodies to eight common neurotropic viruses. Talanta, 31, 889893.Google Scholar
Golden, C. J., Moses, J. A., Zelazowski, R., Graber, B., Zatz, L. M., Horvath, T. B. & Berger, P. A. (1980) Cerebral ventricular size and neuropsychological impairment in young chronic schizophrenics. Archives of General Psychiatry, 37, 619623.Google Scholar
Gotlieb-Stematsky, T., Zonis, J., Arlazoroff, A., Mozes, T., Sigal, M. & Szekely, A. G. (1981) Antibodies to Epstein-Barr Virus, Herpes Simplex type 1, cytomegalo-virus and measles virus in psychiatric patients. Archives of Virology, 67, 333339.Google Scholar
Johnstone, E. C., Frith, C. D., Crow, T. J., Husband, J. & Kreel, L. (1976) Cerebral ventricular size and cognitive impairment in chronic schizophrenia. Lancet, ii, 924926.CrossRefGoogle Scholar
King, D. J., Cooper, S. J., Earle, J. A. P., Martin, S. J., McFerran, N. V., Rima, B. K. & Wisdom, G. B. (1985) A survey of serum antibodies to eight common viruses in psychiatric patients. British Journal of Psychiatry, 147, 137144.Google Scholar
Libíková, H., Breier, S., Kočišova, M., Pogády, J., Stünzner, D. & Ujházyová, D. (1979) Assay of interferon and viral antibodies in the cerebrospinal fluid in clinical neurology and psychiatry. Acta Biologica et Medico Germainica, 38, 879893.Google Scholar
Luchins, D. J., Lewine, R. R. J. & Meltzer, H. Y. (1984) Lateral ventricular size, psychopathology, and medication response in the Psychoses. Biological Psychiatry, 19, 2944.Google Scholar
Nasrallah, H. A., Jacoby, C. G., McCalley-Whitters, M. & Kuperman, S. (1982) Cerebral ventricular enlargement in subtypes of chronic schizophrenia. Archives of General Psychiatry, 39, 774777.CrossRefGoogle ScholarPubMed
Kuperman, S. Kuperman, S., Hamra, B. J. & McCalley-Whitters, M. (1983) Clinical differences between schizophrenic patients with and without large cerebral ventricles. Journal of Clinical Psychiatry, 44, 407409.Google Scholar
Nybäck, H., Wiesel, F. A., Berggren, B. M. & Hindmarsh, T. (1982) Computed tomography of the brain in patients with acute psychosis and in healthy volunteers. Acta Psychiatrica Scandinavica, 65, 403414.Google Scholar
Rieder, R. O., Donnelly, E. F., Herdt, J. R. & Waldman, I. N. (1979) Sulcal prominence in young chronic schizophrenic patients: CT scan findings associated with impairment on neuropsychological tests. Psychiatry Research, 1, 18.CrossRefGoogle ScholarPubMed
Rieder, R. O. Mann, L. S., Weinberger, D. R., van Kammen, D. P. & Post, R. M. (1983) Computed tomographic scans in patients with schizophrenia, schizoaffective, and bipolar affective disorder. Archives of General Psychiatry, 40, 735739.Google Scholar
Rimón, R., Halonen, P., Puhakka, P., Laitinen, L., Marttila, R. & Salmela, L. (1979) Immunoglobulin G antibodies to Herpes Simplex Type 1 virus detected by radioimmunoassay in serum and cerebrospinal fluid of patients with schizophrenia. Journal of Clinical Psychiatry, 40, 241243.Google Scholar
Rimón, R. Nishmi, M. & Halonen, P. (1978) Serum and CSF antibody levels to Herpes Simplex Type 1, measles and rubella viruses in patients with schizophrenia. Annals of Clinical Research, 10, 291293.Google Scholar
Tanaka, Y., Hazama, H., Kawahara, R. & Kobayashi, K. (1981) Computerized tomography of the brain in schizophrenic patients. A controlled study. Acta Psychiatrica Scandinavica, 63, 191197.CrossRefGoogle ScholarPubMed
Torrey, E. F., Peterson, M. R., Bannon, W. L., Carpenter, W. T., Post, R. M. & van Kammen, D. P. (1978) Immunoglobulins and viral antibodies in psychiatric patients. British Journal of Psychiatry, 132, 342348.Google Scholar
Torrey, E. F. Yolken, R. H. & Winfrey, C. J. (1982) Cytomegalovirus antibody in cerebrospinal fluid of schizophrenic patients detected by enzyme immunoassay. Science, 216, 892894.CrossRefGoogle ScholarPubMed
Weinberger, D. R., Delisi, L. E., Perman, G. P., Targum, S. & Wyatt, R. J. (1982) Computed tomography in schizophreniform disorder and other acute psychiatric disorders. Archives of General Psychiatry, 39, 778783.Google Scholar
Weinberger, D. R., Bigelow, L. B., Kleinman, J. E., Klein, S. T., Rosenblatt, J. E. & Wyatt, R. D. (1980) Cerebral ventricular enlargement in chronic schizophrenia. An association with poor response to treatment. Archives of General Psychiatry, 37, 1114.Google Scholar
Weinberger, D. R., Torrey, E. F., Neophytides, A. N. & Wyatt, R. J. (1979) Lateral cerebral ventricular enlargement in chronic schizophrenia. Archives of General Psychiatry, 35, 735739.Google Scholar
Withers, E. & Hinton, J. (1971) Three forms of the clinical tests of the sensorium and their reliability. British Journal of Psychiatry, 119, 18.Google Scholar
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