Hostname: page-component-8448b6f56d-cfpbc Total loading time: 0 Render date: 2024-04-23T13:24:38.432Z Has data issue: false hasContentIssue false
  • English
  • Français

Psychiatric Illness in First-Degree Relatives of Patients with Paranoid Psychosis, Schizophrenia and Medical Illness

Published online by Cambridge University Press:  29 January 2018

Kenneth S. Kendler ,
Catherine C. Masterson  and
Kenneth L. Davis
Kenneth S. Kendler*
Affiliation:
Departments of Psychiatry and Human Genetics, Medical College of Virginia, Richmond, Virginia. Medicine, New York
Catherine C. Masterson
Affiliation:
Schizophrenia Biologic Research Center, Bronx Veteran's Administration Medical Center
Kenneth L. Davis
Affiliation:
Schizophrenia Biologic Research Center, Bronx Veteran's Administration Medical Center and Department of Psychiatry, Mt. Sinai School of Medicine, New York
*
∗Reprint requests to Department of Psychiatry, Medical College of Virginia, PO Box 710, Richmond, VA 23298.
Get access Rights & Permissions [Opens in a new window]

Abstract

This study examines the respective morbid risk for psychiatric illness determined by the family history method in the first-degree relatives of medical controls and patients with delusional disorder (paranoid psychosis) and schizophrenia. The morbid risk for schizophrenia and schizoid-schizotypal personality disorder was significantly greater in the relatives of the schizophrenic patients than in those of the delusional disorder or medical control patients, but no difference in the risk for affective illness or alcoholism was found in the three groups of relatives. Paranoid personality disorder was significantly more common in the relatives of the delusional disorder patients than in those of the medical controls. These results support the familial independence of delusional disorder and schizophrenia.

Type
Papers
Information
The British Journal of Psychiatry , Volume 147 , Issue 5 , November 1985 , pp. 524 - 531
Copyright
Copyright © 1985 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

American Psychiatric Association, Committee on Nomenclature and Statistics (1980) Diagnostic and Statistical Manual of Mental Disorders, ed 3. Washington, DC: American Psychiatric Association.Google Scholar
Andreasen, N. C., Endicott, J., Spitzer, R. L. et al (1977) The family history method using diagnostic criteria: Reliability and validity. Archives of General Psychiatry, 34, 1229–1235.Google Scholar
Debray, Q. (1974) Etude genetique des delires chronique. Thesis. Paris.Google Scholar
Delucchi, K. L. (1983) The use and misuse of chi-square: Lewis and Burke revisited. Psychological Bulletin, 94, 166–176.Google Scholar
Endicott, R., Andreasen, N. & Spitzer, R. L. (1975) Family History—Research Diagnostic Criteria. New York: Biometric Research, New York State Psychiatric Institute.Google Scholar
Feighner, J. P., Robins, E. & Guze, S. B. et al (1971) Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry, 26, 57–63.CrossRefGoogle Scholar
Fischer, M. (1973) Genetic and environmental factors in schizophrenia. Acta Psychiatrica Scandinavica, Supplement 238, 1–153.Google Scholar
Gershon, E. S., Bunney, W. E., Leckman, J. F. et al (1976) The inheritance of affective disorders: A review of data and of hypotheses. Behavior Genetics, 3, 27–261.Google Scholar
Kendler, K. S. (1980) The nosologic validity of paranoia (Simple delusional disorder): A review. Archives of General Psychiatry, 37, 699–706.Google Scholar
Kendler, K. S. (1982) Demography of paranoid psychosis (delusional disorder): A review and comparison with schizophrenia and affective illness. Archives of General Psychiatry, 39, 890–902.Google Scholar
Kendler, K. S. & Davis, K. L. (1981) The genetics and biochemistry of paranoid schizophrenia and other paranoid psychoses. Schizophrenia Bulletin, 7, 689–709.Google Scholar
Kendler, K. S. & Gruenberg, A. M. (1982) Genetic relationship between paranoid personality disorder and the “schizophrenic spectrum” disorders. American Journal of Psychiatry, 139, 1185–1186.Google Scholar
Kendler, K. S. & Gruenberg, A. M. & Strauss, J. S. (1981) An independent analysis of the Copenhagen sample of the Danish Adoption Study of schizophrenia: II. The relationship between schizotypal personality disorder and schizophrenia. Archives of General Psychiatry, 38, 982–984.Google Scholar
Kendler, K. S. & Gruenberg, A. M. & Strauss, J. S. (1981) An independent analysis of the Copenhagen sample of the Danish Adoption Study of schizophrenia: III. The relationship between paranoid psychosis (delusional disorder) and the schizophrenia spectrum. Archives of General Psychiatry, 38, 985–987.Google Scholar
Kendler, K. S., & Gruenberg, A. M. & Tsuang, M. T. (1985) Psychiatric illness in first-degree relatives of schizophrenic and surgical control patients: A family study using DSM-III criteria. Archives of General Psychiatry, 42, 770–779.Google Scholar
Kendler, K. S. & Hays, P. (1981) Paranoid psychosis (delusional disorder) and schizophrenia: A family history study. Archives of General Psychiatry, 38, 547–551.Google Scholar
Kendler, K. S. Masterson, C. C. & Ungaro, R. et al (1984) A family history study of schizophrenia-related personality disorders. American Journal of Psychiatry, 141, 424–427.Google Scholar
Kendler, K. S. & Tsuang, M. T. (1981) Nosology of paranoid schizophrenia and other paranoid psychoses. Schizophrenia Bulletin, 7, 594–610.Google Scholar
Kety, S. S., Rosenthal, D. & Wender, P. H. et al (1975) Mental illness in the biological and adoptive families of adopted individuals who have become schizophrenic: A preliminary report based on psychiatric interviews. In Genetic Research in Psychiatry (eds. Fieve, R., Rosenthal, D. & Brill, H.), pp. 147–165. Baltimore: Johns Hopkins Press.Google Scholar
Kolle, K. (1931) Die Primare Verruckheit. Leipzig: Thieme.Google Scholar
Kraepelin, E. (1902) Clinical Psychiatry: A Textbook for Students and Physicians (trans-ed. Defendorf, A. R.). New York: Macmillan.Google Scholar
Lewis, A. (1970) Paranoia and paranoid: An historical perspective. Psychological Medicine, 1, 2–12.Google Scholar
Lowing, P. A., Mirsky, A. F. & Pereira, R. (1983) The inheritance of schizophrenia spectrum disorders: A renalysis of the Danish Adopted Study data. American Journal of Psychiatry, 140, 1167–1171.Google Scholar
Magaro, P. A. (1981) The paranoid and the schizophrenic: The case for distinct cognitive style. Schizophrenia Bulletin, 7, 632–661.Google Scholar
Mendlewicz, J., Fleiss, J. L., Cataldo, M. & Rainer, J. D. (1975) Accuracy of the family history method in affective illness: Comparison with direct interviews in family studies. Archives of General Psychiatry, 32, 309–314.Google Scholar
Miettinen, O. S. (1974) Comment. Journal of the American Statistical Association, 69, 380–382.Google Scholar
Munro, A. (1982) Paranoia revisited. British Journal of Psychiatry, 141, 344–349.Google Scholar
Retterstol, N. (1967) Sinnsliderlser hos naere skektninger av pasineter med paranoide psykoser. Nordisk Psykialrisk Tiddskrift, 21, 185–194.Google Scholar
Sakel, M. (1958) Schizophrenia. New York: Philosophical Library.Google Scholar
Schneider, K. (1959) Clinical Psychopathology. New York: Grune & Stratton.Google Scholar
Specht, G. (1901) Uber den Pathologischen Affect in der Chronischen Paranoia. Leipzig: Bohme.Google Scholar
Stephens, D. A., Atkinson, M. W. & Kay, D. W. K. et al (1975) Psychiatric morbidity in parents and sibs of schizophrenics and non-schizophrenics. British Journal of Psychiatry, 127, 97–108.Google Scholar
Thompson, W. D., Orvaschel, H. & Prusoff, B. A. et al (1982) An evaluation of the family history method for ascertaining psychiatric disorders. Archives of General Psychiatry, 39, 53–58.CrossRefGoogle ScholarPubMed
Tsuang, M. T. & Winokur, G. (1974) Criteria for subtyping schizophrenia. Archives of General Psychiatry, 31, 43–47.Google Scholar
Watt, J. A. G., Hall, D. J. & Olley, P. C. et al (1980) Paranoid states of middle life: Familial occurrence and relationship to schizophrenia. Acta Psychiatrica Scandinavica, 61, 413–426.Google Scholar
Winokur, G. (1977) Delusional disorder (paranoia). Comprehensive Psychiatry, 18, 511–521.Google Scholar
Winokur, G. Morrison, J. & Clancy, J. et al (1972) The Iowa 500: II. A blind family history comparison of mania, depression, and schizophrenia. Archives of General Psychiatry, 27, 462–464.Google Scholar
World Health Organisation (1978) Mental Disorders: Glossary and Guide to Their Classification in Accordance with the Ninth Revision of the International Classification of Diseases. Geneva: World Health Organisation.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.