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Depression, Urinary Free Cortisol Excretion and Lymphocyte Function

Published online by Cambridge University Press:  29 January 2018

Ziad Kronfol*
Affiliation:
Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
J. Daniel House
Affiliation:
Department of Family Practice, University of Iowa
Joseph Silva Jr
Affiliation:
University of Michigan Medical Center, Ann Arbor, Michigan 48109
John Greden
Affiliation:
University of Michigan
Bernard J. Carroll
Affiliation:
Department of Psychiatry, Duke University School of Medicine, Durham, North Carolina, 27710
*
Correspondence

Abstract

An impairment in lymphocyte response to mitogen stimulation, a correlate of cell-mediated immunity, has been reported in patients with depressive illness. To investigate whether such impairment in lymphocyte function is related to excessive secretion of cortisol, an immunosuppressive hormone, we compared mitogen-induced lymphocyte proliferation in three groups of subjects: (1) depressed patients with elevated 24-hour urinary free Cortisol (UFC) excretion; (2) depressed patients with normal UFC excretion; and (3) normal controls. Depressed patients in both groups showed significant reductions in lymphocyte mitogenic activity, in comparison with the normal controls, but the two depressive groups did not significantly differ from each other in their lymphocytic responses to any of the mitogens used. Furthermore, no significant correlations were found, within depressed patients, between UFC excretion and lymphocyte mitogenic responses. Depression is therefore associated with an impairment in lymphocyte function that cannot be explained solely on the basis of increased cortisol secretion.

Type
Papers
Copyright
Copyright © 1986 The Royal College of Psychiatrists 

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References

Beardwell, C. G., Burke, C. W. & Cope, C. L. (1968) Urinary free Cortisol measured by competitive protein binding. Journal of Endocrinology, 42, 7989.Google Scholar
Britton, S., Thoren, M. & Sjoberg, H. (1975) The immunologic hazard of Cushing's syndrome. British Medical Journal, iv, 678683.Google Scholar
Burke, C. W. & Beardwell, C. G. (1973) Cushing's Syndrome: An evaluation of the clinical usefulness of urinary free cortisol and other urinary steroid measurements in diagnosis. Quarterly Journal of Medicine, 42, 173204.Google ScholarPubMed
Carroll, B. J. (1982) The dexamethasone suppression test for melancholia. British Journal of Psychiatry, 140, 292304.CrossRefGoogle ScholarPubMed
Carroll, B. J., Curtis, G. C. & Mendels, J. (1976a) Cerebrospinal fluid and plasma free Cortisol levels in depression. Psychological Medicine, 6, 235244.CrossRefGoogle ScholarPubMed
Carroll, B. J., Curtis, G. C., Davis, B. M., Mendels, J. & Sugerman, A. (1976b) Urinary free Cortisol excretion in depression Psychological Medicine, 6, 4350.Google Scholar
Carroll, B. J., Curtis, G. C. & Mendels, J. (1976c) Neuroendocrine regulation in depression II: discrimination of depressed from non-depressed patients. Archives of General Psychiatry, 33, 10511058.Google Scholar
Claman, H. (1972) Corticosteriods and lymphoid cells. New England Journal of Medicine, 287, 388397.CrossRefGoogle Scholar
Dougherty, T., Berliner, M., Schneebeli, G. et al. (1964) Hormonal control of lympathic structure and function. Annals of the New York Academy of Science, 113, 825843.Google Scholar
Fauci, A. S. (1978) Clinical aspects of immunosuppression: use of cytotoxic agents and corticosteroids In Immunology II (ed. Bellanti, J. A.) Philadelphia: Saunders.Google Scholar
Hall, N. & Goldstein, A. (1981) Neurotransmitters and the immune system In Psychoneuroimmunology (ed. Ader, R.), New York: Academic Press.Google Scholar
Hamilton, M. (1960) A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry, 23, 5662.Google Scholar
Hsu, T. H. & Bledsoe, T. (1970) Measurement of urinary free corticoids by competitive protein-binding radioassay in hypoadrenal states. Journal of Clinical Endocrinology, 30, 443448.Google Scholar
Kronfol, Z. (1985) Depression and immune disease. Psychiatric Medicine. In press Google Scholar
Kronfol, Z. & House, J. D. (1984) Depression, cortisol and immune function. Lancet, i, 10261027.Google Scholar
Kronfol, Z. & Schlechte, J. (1985) Depression, hormones and immunity In Enkephalins and Endorphins: Stress and the Immune System. (eds. Plotnikoff, N., Murgo, A. J. & Faith, R. E.). In press.Google Scholar
Kronfol, Z., Silva, J., Greden, J., Dembinski, S. & Carroll, B. J. (1982) Cell-mediated immunity in melancholia. Psychosomatic Medicine, 44, 304.Google Scholar
Kronfol, Z., Silva, J., Greden, J., Dembinski, S., Gardner, R. & Carroll, B. J. (1983) Impaired lymphocyte function in depressive illness. Life Sciences, 33, 241247.Google Scholar
Murphy, B. (1968) Clinical evaluation of urinary Cortisol determinations by competitive protein-binding radioassay. Journal of Clinical Endocrinology and Metabolism, 28, 343348.Google Scholar
Oppenheim, J., Dougherty, S. & Chan, S. (1975) Use of lymphocyte transformation to assess clinical disorders In Laboratory Diagnosis of Immunological Disorders (eds. Vyas, G., Stites, D. & Brecher, G.). New York: Grune & Stratton.Google Scholar
Riley, V. (1981) Psychoneuroendocrine influences on immunocompetence and neoplasia. Science, 212, 11001109.Google Scholar
Rogers, M., Dubey, D. & Reich, P. (1979) The influence of the psyche and the brain on immunity and disease susceptibility: a critical review. Psychosomatic Medicine, 41, 147164.Google Scholar
Sachar, E., Hellman, L., Roffwarg, H. et al. (1973) Disrupted 24-hour patterns of Cortisol secretion in psychotic depression. Archives of General Psychiatry, 28, 1924.CrossRefGoogle ScholarPubMed
Schlechte, J. & Sherman, B. (1985) Lymphocyte glucocorticoid receptor binding in depressed patients with hypercortisolemia. Psychoneuroendocrinology. In press.Google Scholar
Schleifer, S., Keller, S., Meyerson, A., Raskin, M., Davis, K. & Stein, M. (1984) Lymphocyte function in major depressive disorder. Archives of General Psychiatry, 41, 484486.CrossRefGoogle ScholarPubMed
Spitzer, R., Endicott, J. & Robins, E. (1977) Research Diagnostic Criteria (RDC) for a Selected Group of Functional Disorders. New York: New York State Psychiatric Institute.Google Scholar
Tyler, F. H. & West, C. D. (1972) Laboratory evaluation of disorders of the adrenal cortex. American Journal of Medicine, 53, 664672.Google Scholar
Van Praag, H. M. (1982) Neurotransmitters and CNS disease: depression. Lancet, II, 12591264.Google Scholar
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