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Should Plasma or Urinary MHPG be Measured in Psychiatric Research? A Critical Comment

Published online by Cambridge University Press:  29 January 2018

J. G. Filser ,
W. E. Müller  and
H. Beckmann
J. G. Filser
Affiliation:
Psychopharmacological Laboratory
W. E. Müller*
Affiliation:
Psychopharmacological Laboratory
H. Beckmann
Affiliation:
Psychiatric Clinic. Present appointment: Psychiatric Clinic, University of Würzburg, D-8700 Würzburg; Central Institute of Mental Health, D-6800 Mannheim, Federal Republic of Germany
*
Correspondence
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Extract

Many experimental findings suggest that disturbances of noradrenergic neurons in the CNS are involved in the pathogenesis of depressive disorders. Moreover, evidence indicates that adaptive changes of central noradrenergic neurons contribute to the biochemical mechanism of action of most anti-depressive treatments (Goodwin, 1984; Johnstone, 1982). Accordingly, assessing the activity of central noradrenergic neurons in depressive patients has become important in psychiatric research.

Type
Comment
Information
The British Journal of Psychiatry , Volume 148 , Issue 1 , January 1986 , pp. 95 - 97
Copyright
Copyright © 1986 The Royal College of Psychiatrists 

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References

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