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Brain Indicators of Altered Attention and Information Processing in Schizophrenic Patients

Published online by Cambridge University Press:  29 January 2018

K. Barrett ,
W. C. McCallum  and
P. V. Pocock
K. Barrett*
Affiliation:
Department of Mental Health, University of Bristol, 39 St Michaels Hill, Bristol BS2 8DZ
W. C. McCallum
Affiliation:
Burden Neurological Institute, Bristol & University of Bristol
P. V. Pocock
Affiliation:
Burden Neurological Institute, Bristol
*
∗Correspondence
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Abstract

Late components of brain event-related potentials reflect aspects of selective attention, stimulus evaluation, and possibly memory update mechanisms. Several of these components were measured during an auditory target detection task, performed by 20 schizophrenic and 20 normal subjects. Both the amplitude of those components and a more general late amplitude measure were significantly reduced in schizophrenics, for both target and non-target stimuli. One general late amplitude measure, from the scalp vertex, could alone correctly classify 85% of patients and 95% of controls. The source of these differences may lie in a protracted positive potential shift.

Type
Papers
Information
The British Journal of Psychiatry , Volume 148 , Issue 4 , April 1986 , pp. 414 - 420
Copyright
Copyright © 1986 The Royal College of Psychiatrists 

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References

Baker, L. A., Cheng, L. Y. & Amara, I. B. (1983) The withdrawal of Benztropine Mesylate in chronic schizophrenic patients. British Journal of Psychiatry, 143, 584–590.CrossRefGoogle ScholarPubMed
Baribeau-Braun, J., Picton, T. W. & Gosselin, J. Y. (1983) Schizophrenia: A neurophysiological evaluation of abnormal information processing. Science, 219, 874–876.CrossRefGoogle ScholarPubMed
Bleuler, E. (1911) Dementia praecox oder die gruppe der Schizophrenien. Translated in 1950 by Zinkin, J. as Dementia praecox or the group of schizophrenias. New York: International Universities Press.Google Scholar
Buchsbaum, M. (1977) The middle evoked response components in schizophrenia. Schizophrenia Bulletin, 3, 93–104.CrossRefGoogle ScholarPubMed
Chapman, J. & McGhie, A. (1962) A comparative study of disordered attention in schizophrenia. Journal of Mental Science, 108, 487–500.CrossRefGoogle ScholarPubMed
Curry, S. H. (1980) Event-related potentials as indicants of structural and functional damage in closed head injury. In Motivation. Motor and Sensory Processes of the Brain: Electrical Potentials Behaviour and Clinical Use. (eds Kornhuber, H. H. & Deecke, L.) Amsterdam. Elsevier/North Holland.Google Scholar
Davis, J. M. (1976) Comparative doses and costs of antipsychotic medication. Archives of General Psychiatry, 33, 858–861.CrossRefGoogle ScholarPubMed
Donchin, E., Ritter, W. & McCallum, W. C. (1978) Cognitive psychophysiology: the endogenous components of the ERP. In Event-Related Brain Potentials in Man. (eds. Callaway, E., Tueting, P., & Koslow, S. H.). New York: Academic Press.Google Scholar
Hansen, J. C. & Hillyard, S. A. (1980) Endogenous brain potentials associated with selective attention. Electroencephalography and Clinical Neurophysiology, 49, 277–290.CrossRefGoogle Scholar
Hillyard, S. A., Picton, T. W. & Regan, D. (1978) Sensation, Perception and Attention: Analysis using ERPs. In Event-Related Brain Potentials in Man. (eds. Callaway, E., Tueting, P. & Koslow, S. H.) New York: Academic Press.Google Scholar
Kessler, K. A. & Waletzky, J. P. (1981) Clinical use of the antipsychotics. American Journal of Psychiatry, 138, 202–209.Google ScholarPubMed
Levtt, A. L., Sutton, S. & Zubin, J. (1973) Evoked potential correlates of information processing in psychiatric patients. Psychological Medicine, 3, 487–494.CrossRefGoogle Scholar
McCallum, W. C. & Curry, S. H. (1978) Hemisphere differences in event-related potentials and CNVs associated with monaural stimuli and lateralized motor response. In Human evoked potentials: Applications and problems, (eds Lehmann, D. & Callaway, E.). New York: Plenum.Google Scholar
McGhie, A. & Chapman, J. (1961) Disorders of attention and perception in early schizophrenia. British Journal of Medical Psychology, 34, 103–116.CrossRefGoogle ScholarPubMed
McGhie, A., Chapman, J. & Lawson, J. S. (1964) Disturbances in selective attention in schizophrenia. Proceedings of the Royal Society of Medicine, 57, 419–22.Google ScholarPubMed
Näätänen, R., Gaillard, A. W. K. & Mantysalo, S. (1978) Early selective-attention effect on evoked potential reinterpreted. Acta Psychologica, 42, 313–329.CrossRefGoogle ScholarPubMed
Näätänen, R. & Michie, P. T. (1979) Early selective attention effects on the evoked potential: A critical review and reinterpretation. Biological Psychology, 8, 81–136.CrossRefGoogle ScholarPubMed
Näätänen, R. & Picton, T. W. (1986) N2 and automatic versus controlled processes. In Cerebral Psychophysiology: Studies in Event-related Potentials, (eds McCallum, W. C., Zappoli, R. & Denoth, F.). Amsterdam, Elsevier. (In press).Google Scholar
Näätänen, R., Simpson, M. & Loveless, N. E. (1982) Stimulus deviance and evoked potentials. Biological Psychology, 14, 53–98.CrossRefGoogle ScholarPubMed
Roth, W. T. & Cannon, E. H. (1972) Some features of the auditory evoked response in schizophrenics. Archives of General Psychiatry, 27, 466–471.CrossRefGoogle ScholarPubMed
Roth, W. T., Horvath, T. B., Pfefferbaum, A. & Kopell, B. S. (1980a) Event related potentials in schizophrenics. Electroencephalography and Clinical Neurophysiology, 48, 127–139.CrossRefGoogle ScholarPubMed
Roth, W. T., Pfefferbaum, A., Horvath, T. B., Berger, P. A. & Kopell, B. S. (1980b) P3 reduction in auditory evoked potentials of schizophrenics. Electroencephalography and Clinical Neurophysiology, 49, 497–505.CrossRefGoogle ScholarPubMed
Shagass, C., Roemar, R. A., Straumaniss, J. & Amadeo, M. (1978) Evoked potential correlates of psychosis. Biological Psychiatry, 13, 163–184.Google ScholarPubMed
Spitzer, R. C., Endicott, J. & Robins, E. (1977) Research Diagnostic Criteria (RDC) for a selected group of functional disorders, 3rd ed. Biometrics Research. New York: New York State Psychiatric Institute.Google Scholar
Stephenson, S. A. & Gibbs, F. A. (1951) A balanced non-cephalic electrode. Electroencephalography and Clinical Neurophysiology, 3, 237–240.CrossRefGoogle ScholarPubMed
Verleger, K. & Cohen, R. (1978) Effects of certainty, modality shift and guess outcome on evoked potentials and reaction times in chronic schizophrenics. Psychological Medicine, 8, 81–93.CrossRefGoogle ScholarPubMed
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974) The measurement and classification of psychiatric symptoms. London: Cambridge University Press.Google Scholar
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