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Identical Twins Discordant for Presenile Dementia of the Alzheimer Type

Published online by Cambridge University Press:  29 January 2018

E. B. Renvoize ,
R. H. S. Mindham ,
M. Stewart ,
R. McDonald  and
D. R. D. Wallace
E. B. Renvoize*
Affiliation:
Bootham Park Hospital, York Y03 7BY
R. H. S. Mindham
Affiliation:
Nuffield Professor of Psychiatry, University of Leeds, 15 Hyde Terrace, Leeds LS2 9LT
M. Stewart
Affiliation:
Senior Registrar in Histopathology, University Hospital, Queen's Medical Centre, Clifton Boulevard, Nottingham NG7 2UH
R. McDonald
Affiliation:
Formerly Consultant Psychiatrist & Medical Director, High Royds Hospital, Menston, Yorks
D. R. D. Wallace
Affiliation:
High Royds Hospital, Menston, Yorks
*
Correspondence
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Extract

In genetically proven identical female twins, discordant for presenile dementia of the Alzheimer type, the affected twin began to dement at the age of 49, and died 15 years later; the diagnosis was confirmed at post-mortem. The surviving twin remains clinically unaffected 20 years after the onset of dementia in her sister. Environmental aetiological factors are postulated to account for this discordance.

Type
Brief Reports
Information
The British Journal of Psychiatry , Volume 149 , Issue 4 , October 1986 , pp. 509 - 512
Copyright
Copyright © 1986 The Royal College of Psychiatrists 

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