Hostname: page-component-8448b6f56d-gtxcr Total loading time: 0 Render date: 2024-04-17T18:28:25.953Z Has data issue: false hasContentIssue false
  • English
  • Français

Trazodone-induced Mania

Published online by Cambridge University Press:  29 January 2018

Haim Y. Knobler ,
Samson Itzchaky ,
Doron Emanuel ,
Roberto Mester  and
Shmuel Maizel
Haim Y. Knobler*
Affiliation:
Hebrew University Medical School
Samson Itzchaky
Affiliation:
Hebrew University Medical School
Doron Emanuel
Affiliation:
Hebrew University Medical School
Roberto Mester
Affiliation:
Hebrew University Medical School
Shmuel Maizel
Affiliation:
Hebrew University Medical School
*
Eitanim Psychiatrie Hospital, Doar Na Shimshon, Jerusalem, Israel.
Get access Rights & Permissions [Opens in a new window]

Abstract

Two bipolar depressed patients and one unipolar depressed patient developed manic Symptoms after receiving trazodone. The Symptoms resolved when the treatment was discontinued or reduced. We believe the two bipolar patients are the first cases of this reaction reported in the literature.

Type
Brief Reports
Information
The British Journal of Psychiatry , Volume 149 , Issue 6 , December 1986 , pp. 787 - 789
Copyright
Copyright © 1986 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Agnoli, A., De Gregorio, M. & Dionisio, A.(1984) Trazodone, a review of clinical literature and personal experience. Psychopathology, 17, 88–103.Google Scholar
Cassano, G. B., Conti, L. Dellosso, L. & Massimetti, G.(1982) Four new atypical antidepressants (trazodone, minaserin, nomifensine, caroxazone): results of controlled trials. In: Typicaland Atypical Antidepressants: Clinical Practice, (eds Costa, E. & Racagni, G.). New York: Raven Press.Google Scholar
Fabre, R. E. Jr., McLendon, D. M. & Gainey, R. N.(1979) Trazodone efficacy in depression: a double-blind comparison with imipramine and placebo in day-hospital type patients. Current Therapeutic Research, 25, 827–834.Google Scholar
Gershon, S.(1984) Comparative side effects profiles of trazodone and imipramine: special reference to geriatrie population. Psychopathology, 17, 39–50.Google Scholar
Gershon, S. & Newton, R.(1980) Lack of anticholinergic side effects with a new antidepressant - trazodone. Journal of Clinical Psychiatry, 41, 100–104.Google Scholar
Kellams, J., Klapper, M. H. & Small, J.(1979) Trazodone, a new antidepressant: efficacy and safety in endogenous depression. Journal of Clinical Psychiatry, 40, 390–395.Google Scholar
Kraft, T. B.(1983) Psychosis following trazodone administration. American Journal of Psychiatry, 140, 1383–1384.Google Scholar
Roy-Byrne, P. P., Joffe, R. T., Uhde, T. W. & Post, R. M.(1984) Approaches to the evaluation and treatment of rapid- cycling affective illness. British Journal of Psychiatry, 145, 543–550.Google Scholar
Taylor, D. P., Hyslop, D. K. & Becker, J. A.(1981) Trazodone does not completely inhibit binding at muscarinic cholinoreceptors. General Pharmacology, 12, 391–392.Google Scholar
Warren, M. & Bick, P. A.(1984) Two case reports of trazodone- induced mania. American Journal of Psychiatry, 141, 1103–1104.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.