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Family-Genetic Studies and Identification of Valid Diagnostic Categories in Adult and Child Psychiatry

Published online by Cambridge University Press:  03 January 2018

James F. Leckman ,
Myrna M. Weissman ,
David L Pauls  and
Kenneth K. Kidd
James F. Leckman*
Affiliation:
Child Study Center and Yale University School of Medicine
Myrna M. Weissman
Affiliation:
Connecticut Mental Health Center and Yale University School of Medicine
David L Pauls
Affiliation:
Child Study Center, Yale University School of Medicine
Kenneth K. Kidd
Affiliation:
Yale University School of Medicine
*
Yale University School of Medicine. P.O. Box 3333, New Haven, Connecticut 06510, USA
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Extract

Family-genetic studies of child and adult psychiatric disorders have become increasingly fashionable over the past decade. The development of structured diagnostic interview schedules, the emergence of uniform diagnostic criteria such as DSM-III, and the use of refined design and analytic techniques from the field of chronic disease epidemiology have made substantial contributions to the methodology of such studies. Advances in molecular genetics, particularly our emerging capacity to perform chromosomal linkage studies throughout the human genome, have renewed hope that the constitutional underpinnings of some psychiatric disorders can be identified and that the pathophysiology of these disorders can be elucidated. Family-genetic techniques in child and adult psychiatry are discussed with a particular focus on their potential value in validating diagnostic categories spanning developmental epochs.

Type
Papers
Information
The British Journal of Psychiatry , Volume 151 , Issue 1 , July 1987 , pp. 39 - 44
Copyright
Copyright © The Royal College of Psychiatrists 

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