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Lithium Toxicity and Mefenamic Acid

A Possible Interaction and the Role of Prostaglandin Inhibition

Published online by Cambridge University Press:  02 January 2018

R. K. Shelley
R. K. Shelley*
Affiliation:
University of Dublin, Trinity College
*
Department of Psychiatry, St James's Hospital, Dublin 8, Ireland
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Abstract

An elderly patient with bipolar manic-depressive psychosis, stabilised satisfactorily on lithium carbonate, developed acute symptoms of lithium toxicity shortly after commencing mefenamic acid. Vulnerability factors for the interaction may have included age, history of cardiac failure, and impaired glomerular function. It is hypothesised that the interaction may have been mediated by inhibition of prostaglandin activity.

Type
Brief Reports
Information
The British Journal of Psychiatry , Volume 151 , Issue 6 , December 1987 , pp. 847 - 848
Copyright
Copyright © Royal College of Psychiatrists, 1987 

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References

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