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Partly Dominant Transmission of Schizophrenia in Iceland

Published online by Cambridge University Press:  02 January 2018

Jon L. Karlsson
Jon L. Karlsson*
Affiliation:
Institute of Genetics, Hraunteig 16, Reykjavik, Iceland
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Abstract

Voluminous data on the familial distribution of schizophrenia in Iceland were evaluated in terms of a partly dominant genetic mechanism. The risks were found in most instances to be proportional to the probability of harbouring the proposed gene, but penetrance rates, which generally are around 25%, appear to be elevated when additional risk factors are present. This occurs in individuals with multiple ill relatives, in offspring of two schizophrenic people, or in monozygotic co-twins. Excessive risks also occur in families with unusually severe disease.

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Information
The British Journal of Psychiatry , Volume 152 , Issue 3 , March 1988 , pp. 324 - 329
Copyright
Copyright © Royal College of Psychiatrists, 1988 

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