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A Clinical Trial of the Efficacy and Acceptability of d-Fenfluramine in the Treatment of Neuroleptic-induced Obesity

Published online by Cambridge University Press:  02 January 2018

E. Goodall ,
Christine Oxtoby ,
Ray Richards ,
Gill Watkinson ,
David Brown  and
Trevor Silversonte
E. Goodall*
Affiliation:
Academic Unit of Human Psychopharmacology, Medical College of St Bartholomew's Hospital
Christine Oxtoby
Affiliation:
Hackney and Homerton Unit
Ray Richards
Affiliation:
Servier Reserach and Development, Fulmer, Slough
Gill Watkinson
Affiliation:
City and Hackney Health District
David Brown
Affiliation:
Medical College of St Bartholomew's Hospital, London
Trevor Silversonte
Affiliation:
Medical College of St Bartholomew's Hospital, London
*
∗St John's Wing, Homerton Hospital, Homerton Grove, London E9 6SR
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Abstract

Twenty-nine overweight schizophrenic patients maintained on depot neuroleptic injections who wished to lose weight took part in a double-blind, placebo-controlled trial of 30 mg d-fenfluramine. All subjects received dietary advice. Sixteen patients completed the 12-week trial. Rate of weight loss was significantly greater in those taking d-fenfluramine. Side-effects were reported, but no deterioration in mental state was noted.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 153 , Issue 2 , August 1988 , pp. 208 - 213
Copyright
Copyright © Royal College of Psychiatrists, 1988 

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