Hostname: page-component-8448b6f56d-42gr6 Total loading time: 0 Render date: 2024-04-24T17:53:38.329Z Has data issue: false hasContentIssue false
  • English
  • Français

The Impact of Molecular Genetics on Our Understanding of the Psychoses

Published online by Cambridge University Press:  02 January 2018

Michael J. Mullan  and
Robin M. Murray
Michael J. Mullan*
Affiliation:
Department of Biochemistry and Molecular Genetics, St Mary's Hospital Medical School, London
Robin M. Murray
Affiliation:
Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF
*
∗Correspondence
Get access Rights & Permissions [Opens in a new window]

Abstract

Studies demonstrating the linkage to separate chromosomal locations of Alzheimer's disease, manic depression, and schizophrenia require re-evaluation of our ideas of their genetic aetiology. This article reviews the findings, and explores the increasing contribution of the ‘new genetics' to our understanding of the organic and functional psychoses.

Type
Review Article
Information
The British Journal of Psychiatry , Volume 154 , Issue 5 , May 1989 , pp. 591 - 595
Copyright
Copyright © Royal College of Psychiatrists, 1989 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Baron, M., Risch, N., Hamburger, R., et al (1987) Genetic linkage between X-chromosome markers and bipolar affective illness. Nature, 326, 289–292.Google Scholar
Baron, M. & Rainer, J. D. (1988) Molecular genetics and human disease. British Journal of Psychiatry, 152, 741–753.Google Scholar
Basset, A., McGillivray, B., Jones, B., et al (1988) Partial trisomy chromosome 5 cosegregating with schizophrenia. Lancet, i, 799–801.CrossRefGoogle Scholar
Bock, G. & Collins, G. M. (1987) Molecular Approaches to Human Polygenic Disease. Ciba Foundation Symposium No. 130. Chichester: John Wiley.Google Scholar
Crow, T. J. (1986) The continuum of psychosis and its implication for the structure of the gene. British Journal of Psychiatry, 149, 419–429.CrossRefGoogle ScholarPubMed
Davies, K. E. (1986) Human Genetic Diseases. Oxford: IRL Press.Google Scholar
Davis, C. G. (1987) The LDL receptor. In Molecular Approaches to Human Polygenic Disease (eds Bock, G. & Collins, G. M.). Chichester: John Wiley.Google Scholar
DeLisi, L., Detera-Wadleigh, S., Goldin, L., et al (1988) Abstracts of the Biennial Winter Workshop in Schizophrenia. Badgastein, Austria. Schizophrenia Research, 1.CrossRefGoogle Scholar
Detera-Wadleigh, S., Berrettini, W., Goldin, L., et al (1987) Close linkage of c-Harvey-ras-1 and the insulin gene to affective disorder is ruled out in three North American pedigrees. Nature, 325, 806–808.Google Scholar
Egeland, J., Gerhard, D., Pauls, D., et al (1987) Bipolar affective disorders linked to DNA markers on chromosome 11. Nature, 325, 783–787.CrossRefGoogle ScholarPubMed
Gershon, E., Hamovit, J., Guroff, J., et al (1982) A family study of schizoaffective, bipolar I, bipolar II, unipolar, and normal control probands. Archives of General Psychiatry, 39, 1157–1167.Google Scholar
Gill, M., McKeon, P. & Humphries, P. (1988) Linkage analysis of manic-depression in an Irish family using H-ras 1 and INS DNA markers. Journal of Medical Genetics, 25, 634–635.CrossRefGoogle Scholar
Gottesman, I. & Shields, J. (1972) Schizophrenia and Genetics: A Twin Study Vantage Point. Orlando: Academic Press.Google Scholar
Gurling, H. M. D. (1985) Application of molecular biology to mental illness. Psychiatric Developments, 3, 257–273.Google Scholar
Gusella, J., Wexler, N., Conneally, M. P., et al (1983) A polymorphic DNA marker genetically linked to Huntington's disease. Nature, 306, 234–238.Google Scholar
Karlsson, J. (1988) Partly dominant transmission of schizophrenia in Iceland. British Journal of Psychiatry, 152, 324–329.CrossRefGoogle ScholarPubMed
Kendler, K. S. (1987) The feasibility of linkage studies in schizophrenia. In Biological perspectives of Schizophrenia (eds Helmchen, H. & Henn, F. A.). Chichester: John Wiley.Google Scholar
Kennedy, J. L., Guiffra, L. A., Moises, H. W. et al (1988) Evidence against linkage of schizophrenia to markers on chromosome 5. Nature, 336, 167–169.CrossRefGoogle ScholarPubMed
Hodgkinson, S., Sherrington, R., Gurling, H., et al (1987) Molecular genetic evidence for the heterogeneity in manic depression. Nature, 325, 805–806.Google Scholar
Mendlewicz, J., Linkowski, P. & Milmotte, J. (1980) Linkage between glucose-6-phosphate dehydrogenase deficiency and manic depressive psychosis. British Journal of Psychiatry, 137, 337–342.Google Scholar
Mendlewicz, J., Simon, P., Sevy, S., et al (1987) Polymorphic DNA marker on X chromosome and manic depression. Lancet, i, 1230–1232.Google Scholar
Mons, R., Breitner, J., Silverman, J., et al (1987) Alzheimer's disease; morbid risk among first-degree relatives approximates 50% by 90 years of age. Archives of General Psychiatry, 44, 405–408.Google Scholar
Neary, D., Snowden, J., Northern, B., et al (1988) Dementia of frontal lobe type. Journal of Neurology, Neurosurgery and Psychiatry, 51, 353–361.Google Scholar
Oliver, C. & Holland, A. (1986) Down's syndrome and Alzheimer's disease: a review. Psychological Medicine, 16, 307–322.CrossRefGoogle ScholarPubMed
O'Rourke, D. H., Gottesman, I. I., Suarez, B. K., et al (1982) Refutation of the single locus model in the aetiology of schizophrenia. American Journal of Human Genetics, 33, 630–649.Google Scholar
Reich, T., Clayton, P. & Winokur, G. (1969) Family history studies; V. The genetics of mania. American Journal of Psychiatry, 125, 1358–1359.Google Scholar
Schellenberg, G. D., Bird, T. D., Wijsman, E. M. et al (1988) Absence of linkage of chromosome 21q21 markers to familial Alzheimer's disease. Science, 241, 1507–1510.CrossRefGoogle ScholarPubMed
Scott, J. (1987) Molecular genetics of common diseases. British Medical Journal, 295, 769–771.Google Scholar
Sherrington, , et al (1988) Localisation of a susceptibility locus for schizophrenia on chromosome 5. Nature, 336, 164–167.Google Scholar
St George-Hyslop, P., Tanzi, R., Polinsky, R., et al (1987) The genetic defect causing familial Alzheimer's disease maps on chromosome 21. Science, 235, 885–889.Google Scholar
Sturt, E. & McGuffin, P. (1985) Can linkage and association resolve the genetic aetiology of psychiatric disorders? Review and argument. Psychological Medicine, 15, 455–462.Google Scholar
Weatherall, D. J. (1985) The ‘new genetics’ and clinical practice. British Medical Journal, 295, 587–588.CrossRefGoogle Scholar
Weatherall, D. J. (1987) Molecular and cell biology in clinical medicine. British Medical Journal, 295, 587–588.CrossRefGoogle ScholarPubMed
Whatley, S. A., Owen, M. J. & Murray, R. M. (1988) Neuropsychiatry disorders and the new genetics. In The Bridge Between Neurology and Psychiatry (eds Trimble, M. & Reynolds, E.). London: Churchill Livingstone.Google Scholar
Van Broeckhoven, C., Genthe, A., Vandenberge, A., et al (1987) Failure of familial Alzheimer's disease to segregate with the A4-amyloid gene in several European families. Nature, 329, 153–155.Google Scholar
Wasmuth, J., Hewitt, J., Smith, B., et al (1988) A highly polymorphic locus very tightly linked to the Huntington's disease gene. Nature, 332, 734–736.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.