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Minaprine: An Anticholinergic-Free Antidepressant?

Results of a Controlled Trial of Mianserin

Published online by Cambridge University Press:  02 January 2018

David Wheatley
David Wheatley*
Affiliation:
The Psychopharmacology Research Group, 11A Manor Court, Hinchley Wood, Surrey KT10 0SP
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Abstract

Minaprine is an amino-phenylpyridazine antidepressant reported to be relatively free of anticholinergic effects, cardiotoxicity, drowsiness, and weight gain. Minaprine (100mg t.d.s. and 100mg b.d.) was compared with mianserin (20 mg t.d.s.) in 117 depressed patients, and all three regimes produced significant reductions in scores on the HRSD at the end of six weeks' treatment. There were no anticholinergic effects, but there was a significantly greater incidence of drowsiness with mianserin than with minaprine.

Type
Brief Report
Information
The British Journal of Psychiatry , Volume 155 , Issue 1 , July 1989 , pp. 106 - 107
Copyright
Copyright © The Royal College of Psychiatrists 

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