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Tardive Dyskinesia in Bipolar Affective Disorder: Relationship to Lithium Therapy

Published online by Cambridge University Press:  02 January 2018

Timothy G. Dinan*
Affiliation:
Department of Psychiatry, Trinity College Medical School, St James's Hospital, Dublin 8, Republic of Ireland
Dora Kohen
Affiliation:
Department of Psychological Medicine, St Bartholomew's Hospital, London
*
Correspondence

Abstract

Forty patients under the age of 60 years with a DSM–III diagnosis of bipolar affective disorder were examined for the presence of tardive dyskinesia. The overall prevalence was 22.5%, with an age-related increase. Patients with and without tardive dyskinesia did not differ in terms of duration of affective illness or exposure to neuroleptics, but those patients with tardive dyskinesia had significantly more psychiatric admissions and were on lithium for significantly greater lengths of time.

Type
Papers
Copyright
Copyright © The Royal College of Psychiatrists 

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References

American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn). Washington DC: APA.Google Scholar
Cole, J. O. Gardos, G., Rapkin, R. M., et al (1984) Lithium carbonate in tardive dyskinesia and schizophrenia. In Tardive Dyskinesia and Affective Disorders (eds Gardos G. & Casey D. E.), pp. 4973. Washington DC: American Psychiatric Association.Google Scholar
Gardos, G. & Casey, D. E., (eds) (1984) Tardive Dyskinesia and Affective Disorders. Washington DC: American Psychiatric Association.Google Scholar
Gardos, G., Cole, J. O., Salomon, M., et al (1987) Clinical forms of severe tardive dyskinesia. American Journal of Psychiatry, 144, 895902.Google Scholar
Gerlach, J., Thorsen, K. & Munkvad, I. (1975) Effect of lithium on neuroleptic-induced tardive dyskinesia compared with placebo in a double-blind crossover trial. Pharmakopsychiatrie/Neuro-Psychopharmakologie, 8, 5156.Google Scholar
Guy, W. (1976) ECDEU Assessment Manual for Psychopharmacology, pp. 534537. Washington DC: US Public Health Service.Google Scholar
Kane, J., Struve, F. A. & Weinhold, P. (1980) Strategy for the study of patients at high risk for tardive dyskinesia. American Journal of Psychiatry, 137, 12651267.Google Scholar
Kane, J. & Smith, J. M. (1982) Tardive dyskinesia: prevalence and risk factors, 1959 to 1979. Archives of General Psychiatry, 39, 473481.Google Scholar
Kane, J., Woerner, M., Weinhold, P., et al (1984) Incidence and severity of tardive dyskinesia in affective illness. In Tardive Dyskinesia and Affective Disorders (eds Gardos G. & Casey D. E.), pp. 2128. Washington DC: American Psychiatric Association.Google Scholar
Klawans, H. L. & Barr, A. (1982) Prevalence of spontaneous lingual-facial-buccal dyskinesias in the elderly. Neurology, 32, 558559.Google Scholar
Prange, A. J., Wilson, I. C. & Morris, C. E. (1973) Preliminary experience with tryptophan and lithium carbonate in the treatment of tardive dyskinesia. Psychopharmacology Bulletin, 9, 3637.Google Scholar
Reda, F. A., Escobar, J. L. & Scanlen, J. M. (1975) Lithium carbonate in the treatment of tardive dyskinesia. American Journal of Psychiatry, 132, 560562.Google Scholar
Rush, M., Diamond, F. & Alport, M. (1982) Depression as a risk factor in tardive dyskinesia. Biological Psychiatry, 17, 387392.Google Scholar
Schooler, N. R. & Kane, J. M. (1982) Research diagnoses for tardive dyskinesia. Archives of General Psychiatry, 39, 486487.Google Scholar
Simpson, G. M. (1973) Tardive dyskinesia. British Journal of Psychiatry, 122, 618.Google Scholar
Smith, J. M., Oswald, W. T., Kucharski, T., et al (1978) Tardive dyskinesia: age and sex differences in hospitalized schizophrenics. Psychopharmacology, 58, 207211.Google Scholar
Waddinoton, J. L., Youssef, H. A., Molloy, A. G., et al (1985) Association of intellectual impairment, negative symptoms and ageing with tardive dyskinesia: clinical and animal studies. Journal of Clinical Psychiatry, 46, 2933.Google Scholar
Waddinoton, J. L. & Youssef, H. A. (1986) An unusual cluster of tardive dyskinesia in schizophrenia: association with cognitive dysfunction and negative symptoms. American Journal of Psychiatry, 143, 11621165.Google Scholar
Waddinoton, J. L. & Youssef, H. A. (1988) Tardive dyskinesia in bipolar affective disorder: ageing, cognitive dysfunction, course of illness and exposure to neuroleptics and lithium. American Journal of Psychiatry, 145, 613616.Google Scholar
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