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Adverse Interaction Between Cimetidine and Chlorpromazine in Two Cases of Chronic Schizophrenia

Published online by Cambridge University Press:  02 January 2018

Alan Byrne  and
Brian O'Shea
Alan Byrne
Affiliation:
Newcastle Hospital, Greystones, Co. Wicklow, Eire
Brian O'Shea*
Affiliation:
Newcastle Hospital, Greystones, Co. Wicklow, Eire
*
∗Correspondence
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Abstract

The treatment of two chlorpromazine-medicated chronic schizophrenics with cimetidine resulted in excessive sedation, which necessitated a reduction in chlorpromazine dosage. Eventual discontinuation of cimetidine therapy led to a return of schizophrenic symptoms, which responded to an increase in chlorpromazine dosage to previous levels.

Type
Brief Report
Information
The British Journal of Psychiatry , Volume 155 , Issue 3 , September 1989 , pp. 413 - 415
Copyright
Copyright © Royal College of Psychiatrists, 1989 

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