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Effects of Ethanol on the NMR Characteristics of Rat Brain

Acute Administration, Dependency, and Long-Term Effects

Published online by Cambridge University Press:  02 January 2018

J. A. O. Besson ,
S. G. Greentree ,
M. A. Foster  and
J. E. Rimmington
J. A. O. Besson*
Affiliation:
Department of Mental Health
S. G. Greentree
Affiliation:
Department of Mental Health
M. A. Foster
Affiliation:
Department of Biomedical Physics and Bioengineering, University of Aberdeen
J. E. Rimmington
Affiliation:
Department of Biomedical Physics and Bioengineering, University of Aberdeen
*
∗Department of Mental Health, University Medical Buildings, Foresterhill, Aberdeen AB9 2ZD
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Abstract

In rats, neither acute administration of ethanol nor the establishment of ethanol dependence by chronic administration for 28 days produced significant 1H-NMR relaxation changes. However, chronic ethanol intake for six months produced a transient rise in T1, with no change in T2 or water content. The significance of these results for study in man is discussed and a hypothesis is proposed to explain discrepant differences between T1, T2 and water content. It is suggested that T1 change with long-term ethanol exposure is related to altered free/bound water state secondary to cell membrane changes.

Type
Papers
Information
The British Journal of Psychiatry , Volume 155 , Issue 6 , December 1989 , pp. 818 - 821
Copyright
Copyright © The Royal College of Psychiatrists, 1989 

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References

Besson, J. A. O., Glen, A. I. M., Forman, E. I., et al (1981) Nuclear magnetic resonance observations in alcoholic cerebral disorder and the role of vasopressin. Lancet, ii, 923–924.Google Scholar
Besson, J. A. O., Glen, E., Glen, I., et al (1986) Essential fatty acids, mean cell volume and NMR of brains in ethanol dependent human subjects. Alcohol and Alcoholism (suppl. I), 577–581.Google Scholar
Chin, J. H. & Goldstein, D. B. (1977) Drug tolerance in bio-membranes: a spin labelled study of effects of ethanol. Science, 196, 684–685.CrossRefGoogle Scholar
Corbett, R. & Leonard, B. E. (1984) Effects of cognitive changes caused by chronic administration of alcohol. Neuropharmacology, 23, 269–271.CrossRefGoogle Scholar
Foster, M. A. (1984) Magnetic resonance – the phenomenon. In Magnetic Resonance in Medicine and Biology (ed. Foster, M. A.), pp. 1–27. Oxford: Pergamon Press.Google Scholar
Hill, M. W. & Bangham, A. D. (1975) General depressant drug dependency: a biophysical hypothesis. Advances in Experimental Medicine and Biology, 59, 1–9.CrossRefGoogle ScholarPubMed
Littlejohn, J. M. & John, G. J. (1977) Synaptosomal membrane lipids of mice during continuous exposure to ethanol. Pharmacology, 29, 579–580.Google Scholar
Logsdail, S., Miller, D., MacManus, D., et al (1987) The effects of moderate blood alcohol levels on T1 and T2 relaxation times in the brains of normal volunteers. Magnetic Resonance in Medicine, 4, 378–379.CrossRefGoogle ScholarPubMed
Manders, A. J., Smith, M. A., Kean, D. M., et al (1985) Brain water measured in volunteers after alcohol and vasopressin. Lancet, ii, 1075.CrossRefGoogle Scholar
Mathur-De Vre, R. (1984) Biomedical implications of the relaxation behaviour of water related to NMR imaging. British Journal of Radiology, 57, 955–976.CrossRefGoogle ScholarPubMed
Popov, N., Pohle, W., Rosler, V., et al (1969) Regionale Verteilung von gamma-Amino-Buttersaure, Glutamnsaure, Asparaginsaure, Dopamin, Noradrenalin und Serotonin in Rattenhirn. Acta Medico Biologica Germanica, 18, 697–702.Google Scholar
Smith, M. A., Chick, J., Kean, D. M., et al (1985) Brain water in chronic alcoholic patients measured by magnetic resonance imaging. Lancet, i, 1273–1274.CrossRefGoogle Scholar
Tesch, P., Schmidt, E. & Schmidt, F. W. (1972) Effects of chronic alcohol abuse on the structural lipids of the human brain. Zeitschrift fur Klinische Chemie und Klinische Biochemie, 10, 410–415.Google Scholar
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