Hostname: page-component-8448b6f56d-xtgtn Total loading time: 0 Render date: 2024-04-23T14:48:44.390Z Has data issue: false hasContentIssue false
  • English
  • Français

Serum Interferon in First Psychotic Attack

Published online by Cambridge University Press:  02 January 2018

D. Becker ,
E. Kritschmann ,
S. Floru ,
Y. Shlomo-David  and
T. Gotlieb-Stematsky
D. Becker*
Affiliation:
Department of Psychiatry
E. Kritschmann
Affiliation:
Department of Psychiatry
S. Floru
Affiliation:
Department of Psychiatry
Y. Shlomo-David
Affiliation:
Central Virology Laboratory
T. Gotlieb-Stematsky
Affiliation:
Central Virology Laboratory; The Chaim Sheba Medical Center, Tel-Hashomer and the Tel-Aviv University, Sackler School of Medicine, Department of Human Microbiology, Ramat-Aviv, Israel
*
∗Department of Psychiatry, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Israel
Get access Rights & Permissions [Opens in a new window]

Abstract

A group of 34 physically healthy young patients, aged 18–27 years at their first psychotic attack, before neuroleptic treatment and admission, were tested simultaneously with 24 age-and sex-matched controls for levels of serum interferon. No statistically significant differences were found between patients and controls. Therefore, no correlation between acute viral infection and schizophrenia was demonstrated.

Type
Brief Reports
Information
The British Journal of Psychiatry , Volume 157 , Issue 1 , July 1990 , pp. 136 - 138
Copyright
Copyright © The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Ahokas, A., Rimon, R., Koskiniemi, M., et al (1987) Viral antibodies and interferon in acute psychiatric disorders. Journal of Clinical Psychiatry, 48, 194–196.Google ScholarPubMed
Albrecht, P., Torrey, E. F., Boone, E., et al (1980) Raised cytomegalovirus antibody level in cerebrospinal fluid of schizophrenic patients. Lancet, ii, 769–772.CrossRefGoogle Scholar
American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM–III). Washington, DC: APA.Google Scholar
Armstrong, J. A. (1971) Semi-micro, dye binding assay for rabbit interferon. Applied Microbiology, 21, 723–725.CrossRefGoogle ScholarPubMed
de Lisi, L. E. & Crow, I. J. (1986) Is schizophrenia a viral or immunologic disorder? Psychiatric Clinics of North America, 2, 115–132.CrossRefGoogle Scholar
Flowers, D. & Scott, G. M. (1985) How useful are serum and CSF interferon levels as rapid diagnostic aid in viral infections. Journal of Medical Virology, 15, 35–47.CrossRefGoogle Scholar
Gotlieb-Stematsky, T., Zonis, J., Arlozoroff, A., et al (1981) Antibodies to Epstein–Barr virus, herpes simplex type 1, cytomegalovirus and measles virus in psychiatric patients. Archives of Virology, 67, 333–339.CrossRefGoogle ScholarPubMed
Hare, E. H. & Walter, S. D. (1978) Seasonal variation in admissions of psychiatric patients and its relation to seasonal variation in their birth. Journal of Epidemiology and Community Health, 32, 47–52.CrossRefGoogle Scholar
Moises, M. W., Schindler, L., Leroux, M., et al (1985) Decreased production of interferon alpha and interferon gamma in leucocyte cultures of schizophrenic patients. Acta Psychiatrica Scandinavica, 72, 45–50.CrossRefGoogle ScholarPubMed
Neoreanu, J., Shif, I. & Gotlieb-Stematsky, T. (1983) Interferon assay in patients suspected of viral infections as a tool for rapid diagnosis. Archives of Virology, 78, 103–107.CrossRefGoogle Scholar
Preble, O. T. & Torrey, E. F. (1985) Serum interferon in a patient with psychosis. American Journal of Psychiatry, 142, 1184–1186.Google Scholar
Rimon, R., Nishmi, M. & Halonen, P. (1978) Serum and CSF antibody levels to herpes simplex type 1, measles and rubella viruses in patients with schizophrenia. Annals of Clinical Research, 10, 291–293.Google ScholarPubMed
Rimon, R., Ahokas, A., Hintikka, J., et al (1985) Serum interferon in schizophrenia. Annals of Clinical Research, 17, 139–140.Google ScholarPubMed
Shrikhande, S., Hirsch, S. R., Coleman, M. A., et al (1985) Cytomegalovirus and schizophrenia. A test of a viral hypothesis. British Journal of Psychiatry, 146, 503–506.CrossRefGoogle ScholarPubMed
Spitzer, R. L., Endicott, J. & Robins, E. (1978) Research Diagnostic Criteria (RDC) for a Selected Group of Functional Disorders (3rd edn). New York: New York State Psychiatric Institute.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.