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Regional Brain Metabolism During Auditory Hallucinations in Chronic Schizophrenia

Published online by Cambridge University Press:  02 January 2018

J. M. Cleghorn ,
E. S. Garnett ,
C. Nahmias ,
G. M. Brown ,
R. D. Kaplan ,
H. Szechtman ,
B. Szechtman ,
S. Franco ,
S. W. Dermer  and
P. Cook
J. M. Cleghorn*
Affiliation:
McMaster University, 1200 Main Street West, Hamilton, Ontario Canada L8N 3Z5
E. S. Garnett
Affiliation:
Nuclear Medicine Department, McMaster University
C. Nahmias
Affiliation:
Radiology, McMaster University
G. M. Brown
Affiliation:
Biomedical Sciences and Psychiatry, McMaster University
R. D. Kaplan
Affiliation:
Psychiatry, McMaster University
H. Szechtman
Affiliation:
Biomedical Sciences, McMaster University
B. Szechtman
Affiliation:
Psychiatry, McMaster University
S. Franco
Affiliation:
Psychiatry, McMaster University
S. W. Dermer
Affiliation:
Hamilton Program for Schizophrenia, McMaster University
P. Cook
Affiliation:
Hamilton Program for Schizophrenia, McMaster University
*
∗Correspondence
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Abstract

Regions of the brain involved in language and attention were studied using [18F]-fluorodeoxyglucose in PET. In nine chronic DSM–III schizophrenic patients who had persistent auditory hallucinations, ten who had recovered from hallucinations and ten normal controls. In none of the regions examined was metabolic activity significantly different in hallucinating patients compared with that in other groups. However, a pattern of seven significant correlations of metabolic activity between language regions and between frontal and parietal cortex characterised the hallucinating but not the other groups. Three of the seven correlations were significantly greater in hallucinating patients than in the two other groups, and six were greater in hallucinating patients than controls. Metabolism in Broca's region and its right-hemisphere homologue correlated positively and significantly in the hallucinating group, as it did in anterior cingulate and left superior temporal areas, and in right frontal and parietal areas. Hallucination ratings correlated with metabolism in the anterior cingulate region.

Type
Papers
Information
The British Journal of Psychiatry , Volume 157 , Issue 4 , October 1990 , pp. 562 - 570
Copyright
Copyright © Royal College of Psychiatrists, 1990 

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Footnotes

Presented by J. M. Cleghorn to the 43rd Annual Convention of the Society of Biological Psychiatry, 4–8, May 1988, Montreal, Canada, and, in part, by E. S. Garnett to the Royal College of Psychiatrists, September 1987, London, England.

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