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Effect of Central Cholinergic Stimulation on Regional Cerebral Blood Flow in Alzheimer's Disease

Published online by Cambridge University Press:  03 January 2018

Ken Wilson ,
David Bowen ,
Paul Francis  and
Philippa Tyrrell
Ken Wilson
Affiliation:
Department of Psychogeriatrics, Mossley Hill Hospital, Park Avenue, Liverpool L18 8BU
David Bowen
Affiliation:
Department of Neurochemistry, Institute of Neurology (Queen Square), 1 Wakefield Street, London WC1N 1PJ
Paul Francis
Affiliation:
Department of Neurochemistry, Institute of Neurology (Queen Square), 1 Wakefield Street, London WC1N 1PJ
Philippa Tyrrell
Affiliation:
MRC Cyclotron Unit, Hammersmith Hospital, DuCane Road, London W12 OHS
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Abstract

Patients with Alzheimer disease (AD) had reduced regional cerebral blood flow (rCBF) in the posterior parietotemporal region compared with controls, as determined with technetium-99m hexamethyl propyleneamine oxime and single photon emission tomography. Central cholinergic stimulation with physostigmine produced a focal increase in rCBF in the posterior parietotemporal region in the patients with AD but not in controls.

Type
The Current Literature
Information
The British Journal of Psychiatry , Volume 158 , Issue 4 , April 1991 , pp. 558 - 562
Copyright
Copyright © Royal College of Psychiatrists, 1991 

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