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A Family with Multiple Instances of Definite, Probable and Possible Early-Onset Alzheimer's Disease

Published online by Cambridge University Press:  02 January 2018

H. Karlinsky ,
E. Madrick ,
J. Ridgley ,
J. M. Berg ,
R. Becker ,
C. Bergeron ,
S. Hodgkinson ,
M. E. Percy  and
D. McLachlan
H. Karlinsky*
Affiliation:
Geriatric Psychiatry Services, Queen Elizabeth Hospital and Toronto Hospital; Assistant Professor of Psychiatry, University of Toronto
E. Madrick
Affiliation:
Familial Alzheimer Disease Registry, Queen Elizabeth Hospital, Toronto
J. Ridgley
Affiliation:
Department of Psychology, Toronto Hospital
J. M. Berg
Affiliation:
University of Toronto; Director of Genetic Services and Biomedical Research, Surrey Place Centre, Toronto
R. Becker
Affiliation:
Department of Medicine, Jewish Rehabilitation Hospital, Montreal
C. Bergeron
Affiliation:
Department of Pathology (Neuropathology), Toronto Hospital
S. Hodgkinson
Affiliation:
Section of Psychiatric Genetics, Institute of Psychiatry, London, England
M. E. Percy
Affiliation:
Neurogenetics Laboratory, Surrey Place Centre and Department of Obstetrics and Gynaecology, University of Toronto
D. McLachlan
Affiliation:
University of Toronto
*
∗Queen Elizabeth Hospital, 550 University Avenue, Toronto, Ontario M5G 2A2, Canada
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Abstract

A family with a multigenerational history of proven or suspected early-onset Alzheimer's disease (AD) consistent with autosomal-dominant inheritance is described. To date, the pedigree comprises five generations in which there are 13 known affected individuals. The mean age of onset of cognitive deficits in those for whom data are available (n = 11) is 47.6 (s.d. 3.0) years and the mean age of death (n = 10) is 58.8 (s.d. 4.0) years. The variability in the extent and quality of available data illustrates the diagnostic difficulties encountered in ascertaining such an extended pedigree, and the need for caution in interpreting the evidence.

Type
Papers
Information
The British Journal of Psychiatry , Volume 159 , Issue 4 , October 1991 , pp. 524 - 530
Copyright
Copyright © 1991 The Royal College of Psychiatrists 

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