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Cosegregation of Christmas Disease and Major Affective Disorder in a Pedigree

Published online by Cambridge University Press:  02 January 2018

Michael Gill*
Affiliation:
Institute of Psychiatry, DeCrespigny Park, London SE5 8AF
David Castle
Affiliation:
Institute of Psychiatry, London
Conor Duggan
Affiliation:
Institute of Psychiatry, London
*
Correspondence

Abstract

Three males with factor-IX deficiency (Christmas disease) in one pedigree all had severe affective disorder. This apparent cosegregation, if true, would support the hypothesis that in some pedigrees, a gene for major affective disorder is located on the X chromosome.

Type
Brief Reports
Copyright
Copyright © The Royal College of Psychiatrists 

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References

Baron, M. (1977) Linkage between an X-chromosome marker (deutan color blindness) and bipolar affective illness. Archives of General Psychiatry, 34, 721725.CrossRefGoogle ScholarPubMed
Baron, M., Risch, N., Hamburger, R., et al (1987) Genetic linkage between X-chromosome markers and bipolar affective illness. Nature, 326, 289292.Google Scholar
Berrettini, W. H., Goldin, L. R., Gelernter, J., et al (1990) X-chromosome markers and manic depressive illness. Archives of General Psychiatry, 47, 366373.Google Scholar
Gershon, E. S., Targum, S. D., Matthysse, S., et al (1979) Color blindness not closely linked to bipolar illness. Archives of General Psychiatry, 36, 14231430.Google Scholar
Giannelli, F., Anson, D. S., Choo, K. H., et al (1984) Characterisation and use of an intragenic polymorphic marker for detection of carriers of haemophilia B (factor IX deficiency). Lancet, i, 239241.Google Scholar
McGuffin, P. (1988) Major genes for major affective disorder? British Journal of Psychiatry, 153, 591596.CrossRefGoogle ScholarPubMed
Mendlewicz, J. & Fleiss, J. L. (1974) Linkage studies with X-chromosome markers in bipolar (manic–depressive) and unipolar (depressive) illness. Biological Psychiatry, 9, 261294.Google Scholar
Mendlewicz, J., Linkowski, P., Guroff, J. J., et al (1979) Color blindness linkage to manic-depressive illness. Archives of General Psychiatry, 36, 14421447.CrossRefGoogle ScholarPubMed
Mendlewicz, J., Simon, P., Sevy, S., et al (1987) Polymorphic DNA marker on X-chromosome and manic–depression. Lancet, i, 12301232.Google Scholar
Risch, N., Baron, M. & Mendlewicz, J. (1986) Assessing the role of X-linked inheritance in bipolar-related major affective disorder. Journal of Psychiatric Research, 20, 275288.Google Scholar
Spitzer, R. L., Endicott, J. & Robins, E. (1978) Research Diagnostic Criteria (RDC) for a Selected Group of Functional Disorders (3rd edn). New York: New York State Psychiatric Institute.Google Scholar
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