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Enhanced Serotonergic Responsivity Following Electroconvulsive Therapy in Patients with Major Depression

Published online by Cambridge University Press:  02 January 2018

Baruch Shapira ,
Bernard Lerer ,
Seth Kindler ,
Pesach Lichtenberg ,
Cornelius Gropp ,
Thomas Cooper  and
Avraham Calev
Baruch Shapira*
Affiliation:
Depression Treatment Unit, Ezrath Nashim Hospital, and Department of Psychiatry, Hebrew University, PO Box 140, Jerusalem, 91001, Israel
Bernard Lerer
Affiliation:
Biological Psychiatry Laboratory, Department of Psychiatry, Hadassah University Hospital, and Department of Psychiatry, Hebrew University
Seth Kindler
Affiliation:
Yaacov Herzog Center for Brain and Ezrath Nashim Hospital
Pesach Lichtenberg
Affiliation:
Ezrath Nashim Hospital
Cornelius Gropp
Affiliation:
Ezrath Nashim Hospital
Thomas Cooper
Affiliation:
Analytical Psychopharmacology Laboratory, Nathan Kline Institute, Orangeburg, New York, USA
Avraham Calev
Affiliation:
Yaacov Herzog Center for Brain and Psychiatry Research, Ezrath Nashim Hospital
*
∗Correspondence
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Abstract

Prolactin release in response to fenfluramine hydrochloride (60 mg orally) and placebo was evaluated in 18 medication-free patients with RDC major depressive disorder, endogenous subtype, before and after a series of bilateral treatments with ECT. Before ECT, fenfluramine induced a twofold increase in plasma prolactin levels. This response was significantly enhanced after the ECT series, while baseline prolactin levels and response to the placebo challenge were not altered. There was no significant difference in plasma fenfluramine and norfenfluramine levels during the pre- and post-ECT challenges. These findings suggest that ECT enhances central serotonergic responsivity and extend to depressed patients pre-clinical observations regarding the effect of electroconvulsive shock on serotonergic function.

Type
Papers
Information
The British Journal of Psychiatry , Volume 160 , Issue 2 , February 1992 , pp. 223 - 229
Copyright
Copyright © Royal College of Psychiatrists, 1992 

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References

Asnis, G. M., Eisenberg, J., van Praag, H. M., et al (1988) The neuroendocrine response to fenfluramine in depressives and normal controls. Biological Psychiatry, 24, 117–120.CrossRefGoogle ScholarPubMed
Bolwig, T. G., Herz, M. M., Paulson, O. B., et al (1977) The permeability of the blood brain barrier during electroconvulsive induced seizures in man. European Journal of Clinical Investigation, 7, 87–93.Google Scholar
Brandon, S., Cowley, P., McDonald, C., et al (1984) Electroconvulsive therapy: results in depressive illness from the Leicestershire trial. British Medical Journal, 228, 22–25.Google Scholar
Charney, D. S., Heninger, G. R. & Sternberg, D. E. (1984) Serotonin function and mechanism of action of antidepressant treatment: effect of amitriptyline and desipramine. Archives of General Psychiatry, 41, 359–365.CrossRefGoogle ScholarPubMed
Christie, J. E., Whalley, L. J., Brown, N. S., et al (1982) Effect of ECT on the neuroendocrine response to apomorphine in severely depressed patients. British Journal of Psychiatry, 133, 416.Google Scholar
Coccaro, E. F., Siever, L. J., Klar, H. M., et al (1989) Serotonergic studies with patients with affective and personality disorders. Archives of General Psychiatry, 46, 587–599.Google Scholar
Consensus Conference (1985) Electroconvulsive therapy. Journal of the American Medical Association, 254, 2103–2108.CrossRefGoogle Scholar
Coppen, A., Prange, A. J. Jr, Whybrow, P. C., et al (1972) Abnormalities of indoleamines in affective disorders. Archives of General Psychiatry, 30, 56–62.Google Scholar
Coppen, A., Rao, V. A., Bishop, M., et al (1980) Neuroendocrine studies in affective disorders. Part I. Plasma prolactin response to thyrotropin-releasing hormone in affective disorders: effect of ECT. Journal of Affective Disorders, 2, 311–315.Google Scholar
Costa, E. A., Groppetti, A. & Refuelta, A. (1971) Action of fenfluramine on monoamine stores of rat tissue. British Journal of Pharmacology, 41, 57–64.Google Scholar
Costain, D. W., Green, A. R. & Grahame-Smith, D. G. (1979) Enhanced 5–hydroxytryptamine-mediated behavioral responses in rats following repeated electroconvulsive shock: relevance to the mechanism of the antidepressive effect of electroconvulsive therapy. Psychopharmacology, 61, 167–170.Google Scholar
Costain, D. W., Cowen, P. J., Gelder, M. G., et al (1982) Electroconvulsive therapy and the brain: evidence for increased dopamine-mediated responses. Lancet, ii, 400–404.Google Scholar
Cowen, P. J., Gadhvi, H., Gosden, B., et al (1985) Responses of prolactin and growth hormone to l-tryptophan infusion: effects in normal subjects and schizophrenic patients receiving neuroleptics. Psychopharmacology, 86, 164–169.Google Scholar
Cowen, P. J., Geaney, D. P., Schachter, M., et al (1986) Desipramine in normal subjects: effects on neuroendocrine responses to tryptophan and on platelet serotonin (5–HT)-related receptors. Archives of General Psychiatry, 43, 61–67.Google Scholar
De Montigny, C. (1983) Electroconvulsive shock treatments enhance responsiveness of forebrain neurons to serotonin. Journal of Pharmacology and Experimental Therapeutics, 228, 230–234.Google Scholar
De Montigny, C. & Aghajanian, G. K. (1978) Tricyclic antidepressants: long-term treatment increases responsivity of rat forebrain neurons to serotonin. Science, 202, 1303–1306.Google Scholar
Di Kenzo, G., Salvatore, A., Taglialatela, M., et al (1989) Pharmacological characterization of serotonin receptors involved in the control of prolactin secretion. European Journal of Pharmacology, 162, 371–373.Google Scholar
Fink, M. (1979) Convulsive Therapy: Theory and Practice. New York: Raven Press.Google Scholar
Fink, M. & Ottoson, J. O. (1980) A theory of convulsive therapy in endogenous depression: significance of hypothalamic functions. Psychiatry Research, 2, 49–61.Google Scholar
Freeman, C. P. L., Basson, J. V. & Crighton, A. (1978) Double blind controlled trial of electroconvulsive therapy (ECT) and simulated ECT in depressive illness. Lancet, i, 738–740.Google Scholar
Fuxe, K., Farnebo, L. O., Hamberger, B., et al (1975) On the in vivo and in vitro actions of fenfluramine and its derivatives on central monoamine neurons especially, 5–hydroxytryptamine neurons, and their relation to the anorectic activity of fenfluramine. Postgraduate Medical Journal, 51 (suppl. 1), 35–45.Google Scholar
Grahame-Smith, D. G., Green, A. R. & Costain, D. W. (1978) Mechanism of antidepressant action of electroconvulsive therapy. Lancet, i, 245–256.Google Scholar
Gregory, S., Shawcross, C. R. & Gill, D. (1965) The Nottingham ECT study. A double-blind comparison of bilateral, unilateral and simulated ECT in depressive illness. British Medical Journal, 146, 520–524.Google Scholar
Guy, W. (1976) ECDEU Assessment Manual for Psychopharmacology. Bethesda: US Department of Health Education and Welfare.Google Scholar
Johnstone, E. C., Lawler, P., Stevens, M., et al (1980) The Northwick Park electroconvulsive therapy trial. Lancet, ii, 1317–1320.Google Scholar
Kellar, K. J., Cascio, C. S., Butler, J. A., et al (1981) Differential effects of electroconvulsive shock and antidepressant drugs on serotonin-2 receptors in rat brain. European Journal of Pharmacology, 69, 515–518.Google Scholar
Kety, S. (1974) Biochemical and neurochemical effects of electroconvulsive shock. In Psychobiology of Convulsive Therapy (eds Fink, M., Kety, S., McGough, J., et al). Washington, DC: HV Winston.Google Scholar
Krebs, H. A., Chens, L. K. & Wright, G. J. (1984) Determination of fenfluramine and norfenfluramine in plasma using a nitrogen-sensitive detector. Journal of Chromatography, 8, 103–107.Google Scholar
Lapin, I. P. & Oksenkrug, G. F. (1969) Intensification of the central serotonergic processes as a possible determinant of the thymoleptic effect. Lancet, i, 132–136.Google Scholar
Lerer, B. (1987) Neurochemical and other neurobiological consequences of ECT: implications for the pathogenesis and treatment of affective disorders. In Psychopharmacology: The Third Generation of Progress (ed. Meltzer, H. Y.). New York: Raven Press.Google Scholar
Lerer, B. & Sitaram, N. (1983) Clinical strategies for evaluating ECT mechanisms: pharmacological, biochemical and psychophysiological approaches. Progress in Neuropsychopharmacology and Biological Psychiatry, 7, 309–333.CrossRefGoogle ScholarPubMed
Lerer, B., Weiner, R. D. & Belmaker, R. H. (eds) (1984) ECT: Basic Mechanisms. London: John Libbey.Google Scholar
Lerer, B., Ran, A., Blackler, M., et al (1988) Neuroendocrine responses in chronic schizophrenia: evidence for serotonergic dysfunction. Schizophrenia Research, 1, 405–410.Google Scholar
Lewis, D. A. & Sherman, B. M. (1985) Serotonergic regulation of prolactin and growth hormone secretion in man. Acta Endocrinologica, 110, 152–157.Google Scholar
McBride, F. A., Anderson, G. M., Hertzig, M. E., et al (1989) Serotonergic responsivity in male young adults with autistic disorder. Archives of General Psychiatry, 46, 213–221.CrossRefGoogle ScholarPubMed
Meltzer, H. Y., Lowy, M., Robertson, A., et al (1984) Effect of 5–hydroxytryptophan on serum Cortisol levels in patients with major affective disorders: III. Effect of antidepressants and lithium carbonate. Archives of General Psychiatry, 41, 391–397.Google Scholar
Meltzer, H. Y. & Lowy, M. (1987) The serotonin hypothesis of depression. In Psychopharmacology: The Third Generation of Progress (ed. Meltzer, H. Y.). New York: Raven Press.Google Scholar
Mitchell, P. & Smythe, G. (1990) Hormonal responses to fenfluramine in depressed and control subjects. Journal of Affective Disorders, 19, 43–51.Google Scholar
Newman, M. E., Miskin, I. & Lerer, B. (1987) Effects of single and repeated electroconvulsive shock administration on inositol phosphate in rat brain slices. Journal of Neurochemistry, 49, 19–23.Google Scholar
Newman, M. E. & Lerer, B. (1988) Chronic electroconvulsive shock and desipramine reduce the degree of inhibition by 5-HT and carbachol of forskolin-stimulated adenylate cyclase in rat hippocampal membranes. European Journal of Pharmacology, 148, 257–260.Google Scholar
Newman, M. E. & Lerer, B. (1989) Modulation of second messenger function in rat brain by in vivo alteration of receptor sensitivity: relevance to mechanism of action of electroconvulsive therapy and antidepressants. Progress in Neuropsychopharmacology and Biological Psychiatry, 13, 1–30.Google Scholar
Preziosi, P. (1983) Serotonin control of prolactin release: an intriguing puzzle. Trends in Pharmacological Sciences, 4, 171–174.Google Scholar
Price, L. H., Charney, D. S., Delgado, P. L., et al (1989) Effects of desipramine and fluvoxoamine treatment on the prolactin response to tryptophan: serotonergic function and the mechanism of antidepressant action. Archives of General Psychiatry, 46, 625–631.Google Scholar
Quattrone, A., Direnzo, G., Schettini, G., et al (1978) Increased plasma prolactin levels induced by d-fenfluramine: relation to central serotonergic stimulation. European Journal of Pharmacology, 49, 163–167.Google Scholar
Quattrone, A., Tedesci, G., Aguglia, F., et al (1983) Prolactin secretion in man: a useful tool to evaluate the activity of drugs on central 5–hydroxytryptaminergic neurones: studies with fenfluramine. British Journal of Clinical Pharmacology, 16, 471–475.Google Scholar
Sackeim, H. A., Decina, P., Prohovnik, I., et al (1983) Anticonvulsant and antidepressant properties of ECT: a proposed mechanism of action. Biological Psychiatry, 18, 1301–1309.Google Scholar
Sackeim, H. A., Decina, P., Portnoy, S., et al (1987) Studies of dosage, seizure duration in ECT. Biological Psychiatry, 22, 249–268.Google Scholar
Shapira, B., Reiss, A., Kaiser, N., et al (1989) Effect of imipramine treatment on the prolactin response to fenfluramine and placebo challenge in depressed patients. Journal of Affective Disorders, 16, 1–4.CrossRefGoogle ScholarPubMed
Siever, L. J., Murphy, D. L., Slater, S., et al (1984) Plasma prolactin changes following fenfluramine in depressed patients compared to controls: an evaluation of central serotonergic responsivity in depression. Life Sciences, 34, 1029–1039.CrossRefGoogle ScholarPubMed
Slade, A. P. & Checkley, S. A. (1980) A neuroendocrine study of the mechanism of action of ECT. British Journal of Psychiatry, 137, 217–221.Google Scholar
Spitzer, R. L., Endicott, J. & Robins, E. (1978) Research Diagnostic Criteria: rationale and reliability. Archives of General Psychiatry, 35, 773–782.Google Scholar
West, E. D. (1981) Electric convulsive therapy in depression: a double-blind controlled trial. British Medical Journal, 282, 355–357.Google Scholar
Weizman, A., Mark, M., Gil-Ad, I., et al (1988) Plasma Cortisol, prolactin, growth hormone and immunoreactive β-endorphin response to fenfluramine challenge in depressed patients. Clinical Neuropharmacology, 11, 250–256.Google Scholar
Willner, P. (1985) Antidepressants and serotonergic neurotransmission: an integrative review. Psychopharmacology, 85, 387–404.Google Scholar
Vetulani, J., Lebrecht, U. & Pilc, A. (1981) Enhancement of responsiveness of the central serotonergic system and serotonin-2 receptor density in rat frontal cortex by electroconvulsive treatment. European Journal of Pharmacology, 76, 81–85.Google Scholar
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