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Decreased 5-HT-Mediated Prolactin Release in Major Depression

Published online by Cambridge University Press:  02 January 2018

I. M. Anderson ,
C. J. Ware ,
J. M. da Roza Davis  and
P. J. Cowen
I. M. Anderson
Affiliation:
University Department of Psychiatry and MRC Unit of Clinical Pharmacology, Littlemore Hospital, Oxford OX4 4XN
C. J. Ware
Affiliation:
Littlemore Hospital, Oxford
J. M. da Roza Davis
Affiliation:
Littlemore Hospital, Oxford
P. J. Cowen*
Affiliation:
Littlemore Hospital, Oxford
*
∗Correspondence
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Abstract

The prolactin response to intravenous clomipramine, a 5-HT uptake inhibitor, was significantly attenuated in 12 patients with major depression. In contrast, in a further 12 depressed patients, the PRL responses to thyrotropin-releasing hormone, which acts directly on the pituitary to release PRL, were not reduced. These findings suggest that the reduction in 5-HT-mediated PRL release seen in depressed patients is due to an impairment of brain 5-HT function rather than a pituitary abnormality.

Type
Papers
Information
The British Journal of Psychiatry , Volume 160 , Issue 3 , March 1992 , pp. 372 - 378
Copyright
Copyright © Royal College of Psychiatrists, 1992 

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References

American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn). Washington, DC: APA.Google Scholar
Anderson, I. M., Parry-Billings, M., Newsholme, E. A., et al (1990a) Dieting reduces plasma tryptophan and alters brain 5-HT function in women. Psychological Medicine, 20, 785–791.CrossRefGoogle ScholarPubMed
Anderson, I. M., Cowen, P. J. & Grahame-Smith, D. G. (1990b) The effects of gepirone on neuroendocrine function and temperature in humans. Psychopharmacology, 100, 498–503.CrossRefGoogle ScholarPubMed
Anderson, I. M. & Cowen, P. J. (1991) Prolactin response to the dopamine antagonist, metoclopramide, in depression. Biological Psychiatry, 30, 313–316.CrossRefGoogle Scholar
Asnis, G. M., Eisenberg, J., Van Praag, H. M., et al (1988) The neuroendocrine responses to fenfluramine in depressives and normal controls. Biological Psychiatry, 24, 117–120.CrossRefGoogle ScholarPubMed
Baumgartner, A., Gräf, K.-J. & Kürten, I. (1988) Prolactin in patients with major depressive disorder and in healthy subjects. I. Cross-sectional study of basal and post-TRH and post$dexamethasone prolactin levels. Biological Psychiatry, 24, 249–267.CrossRefGoogle Scholar
Beck, A. T., Ward, C. H., Mendelson, M., et al (1961) An inventory for measuring depression. Archives of General Psychiatry, 4, 561–567.CrossRefGoogle ScholarPubMed
Brambilla, F., Smeraldi, E., Sacchetti, E., et al (1978) Deranged anterior pituitary responsiveness to hypothalamic hormones in depressed patients. Archives of General Psychiatry, 35, 1231–1238.CrossRefGoogle ScholarPubMed
Cella, S., Penalva, A., Locatelli, V., et al (1983) Neuroendocrine studies with fluvoxamine: animal data. British Journal of Clinical Pharmacology, 15, 357 S-3–63S.CrossRefGoogle ScholarPubMed
Checkley, S. A. (1980) Neuroendocrine tests of monoamine function in man: a review of basic theory and its application to the study of depressive illness. Psychological Medicine, 10, 35–53.CrossRefGoogle Scholar
Coccaro, E. F., Siever, L. J., Klar, H. M., et al (1989) Serotonergic studies in patients with affective and personality disorders. Archives of General Psychiatry, Alb46, 587–599.CrossRefGoogle Scholar
Cowen, P. J. & Anderson, I. M. (1986) 5-HT neuroendocrinology: changes during depressive illness and antidepressant drug treatment. In The Biology of Depression (ed. Deakin, J. F. W.). London: Gaskell.Google Scholar
Cowen, P. J. & Charig, E. M. (1987) Neuroendocrine responses to intravenous tryptophan in major depression. Archives of General Psychiatry, 44, 958–966.CrossRefGoogle ScholarPubMed
Cowen, P. J. & Anderson, I. M. (1990) Investigations of 5-HT neuroendocrine function in depression. In Serotonin: from Cell Biology to Pharmacology and Therapeutics (eds Paoletti, R., Vanhoutte, P. M., Brunello, N., et al). Dordecht: Kluwer Academic Publishers.Google Scholar
Cowen, P. J., Anderson, I. M. & Gartside, S. E. (1990) Endocrinological responses to 5-HT. Annals of the New York Academy of Sciences, 600, 250–259.CrossRefGoogle ScholarPubMed
Deakin, J. F. W., Pennell, I., Upadhyaya, A. J., et al (1990) A neuroendocrine study of 5-HT function in depression: evidence for biological mechanisms of endogenous and psychosocial causation. Psychopharmacology, 101, 85–92.CrossRefGoogle ScholarPubMed
Fessler, R. G., Deyo, S. N., Meltzer, H. Y., et al (1984) Evidence that the medial and dorsal raphe nuclei mediate serotonergically-induced increases in prolactin release from the pituitary. Brain Research, 299, 231–237.CrossRefGoogle ScholarPubMed
Gershengorn, M. C. (1986) Mechanism of thyrotropin releasing hormone stimulation of pituitary hormone secretion. Annual Review of Physiology, 48, 515–526.CrossRefGoogle ScholarPubMed
Golden, R. N., Hsiao, J., Lane, E., et al (1989) The effects of intravenous clomipramine on neurohormones in normal subjects. Journal of Clinical Endocrinology and Metabolism, 68, 632–637.CrossRefGoogle ScholarPubMed
Golden, R. N., Hsiao, J., Lane, E., et al (1990) Abnormal neuroendocrine responsivity to acute i.v. clomipramine challenge in depressed patients. Psychiatry Research, 31, 39–47.CrossRefGoogle ScholarPubMed
Goodwin, F. K. & Post, R. M. (1983) 5-hydroxytryptamine and depression: a model for the interaction of normal variance with pathology. British Journal of Clinical Pharmacology, 15, 393 S–405S.CrossRefGoogle Scholar
Goodwin, F. K., Fairburn, C. F. & Cowen, P. J. (1987) Dieting changes serotonergic function in women, not men: implications for the aetiology of anorexia nervosa? Psychological Medicine, 17, 839–842.CrossRefGoogle Scholar
Hall, H. & Ögren, S.-O. (1981) Effects of antidepressant drugs on different receptors in the brain. European Journal of Pharmacology, 70, 393–407.CrossRefGoogle ScholarPubMed
Hamilton, M. (1967) Development of a rating scale for primary depressive illness. British Journal of Social and Clinical Psychology, 6, 278–296.CrossRefGoogle ScholarPubMed
Heninger, G. R., Charney, D. S. & Sternberg, D. E. (1984) Serotonergic function in depression. Archives of General Psychiatry, 41, 398–402.CrossRefGoogle ScholarPubMed
Heninger, G. R., Charney, D. S. Price, L., et al (1990) Neuroendocrine effect of serotonin agonists in rhesus monkeys, healthy humans and patients with depression or anxiety disorders: effects of antidepressant treatment. In Serotonin, from Cell Biology to Pharmacology and Therapeutics (eds Paoletti, R., Vanhoutte, P. M., Brunello, N., et al). Dordecht: Kluwer Academic Publishers.Google Scholar
Jacobs, L. S., Snyder, P. J., Utiger, R. D., et al (1973) Prolactin response to thyrotropin-releasing hormone in normal subjects. Journal of Clinical Endocrinology and Metabolism, 36, 1069–1073.CrossRefGoogle ScholarPubMed
Kahn, R. S., Wetzler, S., Asnis, G., et al (1990) Serotonin receptor sensitivity in major depression. Biological Psychiatry, 28, 358–362.CrossRefGoogle ScholarPubMed
Koyama, T. & Meltzer, H. Y. (1986) A biochemical and neuroendocrine study of the serotonergic system in depression. In New Results in Depression Research (eds Hippius, H., Klerman, G. L. & Matussek, N.). Berlin: Springer-Verlag.Google Scholar
Laakmann, G., Chuang, I., Gugath, M., et al (1983) Prolactin and antidepressants. In Prolactin and Prolactinomas (ed. Tolis, G.). New York: Raven Press.Google Scholar
Lopez, F., Gongalez, D. & Aguilar, E. (1987) Possible direct effect of serotonin on pituitary prolactin secretion: in vivo and in vitro studies. Hormone Research, 25, 160–170.Google ScholarPubMed
Lopez-Ibor, J. J., Saiz-Ruiz, J. & Moral Iglesias, L. (1989) Neuroendocrine challenges in the diagnosis of depressive disorders. British Journal of Psychiatry, 154 (suppl. 4), 73–76.CrossRefGoogle Scholar
Meltzer, H. Y. (1989) Serotonin dysfunction in depression. British Journal of Psychiatry, 155 (suppl. 8), 25–31.CrossRefGoogle Scholar
Meltzer, H. Y. (1990) Role of serotonin in depression. Annals of the New York Academy of Sciences, 600, 486–500.CrossRefGoogle ScholarPubMed
Minamitani, N., Minamitani, T., Lechan, R. M., et al (1987) Paraventricular nucleus mediates prolactin secretory responses to restraint stress, ether stress, and 5-hydroxy-L-tryptophan injection in the rat. Endocrinology, 120, 860–867.CrossRefGoogle ScholarPubMed
Mitchell, P. & Smythe, G. (1990) Hormonal responses to fenfluramine in depressed and control subjects. Journal of Affective Disorders, 19, 43–51.CrossRefGoogle ScholarPubMed
Morgan, W. M. & Herbert, D. C. (1978) Elevation of serum prolactin levels after the inhibition of serotonin uptake. Endocrinology, 103, 1016–1022.CrossRefGoogle ScholarPubMed
Ross, S. B. & Renyi, A. L. (1975) Tricyclic antidepressant agents: comparison of the inhibition of 3H-noradrenaline and 14C-5-hydroxytryptamine in slices and crude synaptosome preparations of the midbrain-hypothalamus region of the rat brain. Acta Pharmacologica et Toxicologia, 36, 382–394.CrossRefGoogle Scholar
Rubin, R. T., Poland, R. E., Lesser, I. M., et al (1989) Neuroendocrine aspects of primary endogenous depression. V. Serum prolactin measures in patients and matched control subjects. Biological Psychiatry, 25, 4–21.CrossRefGoogle ScholarPubMed
Shimatsu, A., Kato, Y., Matsushita, N., et al (1982) Stimulation by serotonin of vasoactive intestinal polypeptide release into rat hypophyseal portal blood. Endocrinology, 111, 338–344.CrossRefGoogle Scholar
Siever, L. J., Murphy, D. L., Slater, S., et al (1984) Plasma prolactin changes following fenfluramine in depressed patients compared to controls. An evaluation of central serotonergic responsivity in depression. Life Sciences, 34, 1029–1039.CrossRefGoogle ScholarPubMed
Stobie, J. M. & Shin, S. M. (1983) Serotonin stimulates prolactin secretion in the hypophysectomised aderhypophyseal grafted rat. Acta Endocrinologica, 102, 511–516.Google Scholar
Targum, S. D., Sullivan, A. C. & Byrnes, S. M. (1982) Compensatory pituitary thyroid mechanisms in major depressive disorder. Psychiatry Research, 6, 85–96.CrossRefGoogle ScholarPubMed
Targum, S. D. & Marshall, L. E. (1989) Fenfluramine provocation of anxiety in patients with panic disorder. Psychiatry Research, 28, 295–306.CrossRefGoogle ScholarPubMed
Tuomisto, J. & Männistö, P. (1985) Neurotransmitter regulation of anterior pituitary hormones. Pharmacological Reviews, 37, 249–332.Google ScholarPubMed
Unden, F., Ljunggren, J.-G., Kjellman, B. F., et al (1987) Unaltered 24 h serum PRL levels and PRL response to TRH in contrast to decreased 24 h serum TSH levels and TSH response to TRH in major depressive disorders. Acta Psychiatrica Scandinavica, 75, 131–138.CrossRefGoogle Scholar
Van Praag, H. M., Lemus, C. & Kahn, R. (1986) The pitfalls of serotonin precursors as challengers in hormonal probes of central serotonergic activity. Psychopharmacology Bulletin, 22, 565–570.Google Scholar
Weizman, A., Mark, M., Gil-Ad, I., et al (1988) Plasma Cortisol, prolactin, growth hormone, and immunoreactive β-endorphin response to fenfluramine challenge in depressed patients. Clinical Neuropharmacology, 3, 250–256.CrossRefGoogle Scholar
Winokur, A., Amsterdam, J. D., Oler, J., et al (1983) Multiple hormonal responses to protirelin (TRH) in depressed patients. Archives of General Psychiatry, 40, 525–531.CrossRefGoogle ScholarPubMed
Wrrschy, J. K., Schlesser, M. A., Fulton, C. L., et al (1984) TRH-induced prolactin release is blunted in females with endogenous unipolar major depression. Psychiatry Research, 12, 321–331.Google Scholar
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