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Schizophrenia Following Pre-natal Exposure to Influenza Epidemics Between 1939 and 1960

Published online by Cambridge University Press:  02 January 2018

Pak C. Sham
Affiliation:
Genetics Section, Institute of Psychiatry, London
Eadbhard O'Callaghan
Affiliation:
Cluain Mhuire Family Centre, Blackrock, Co. Dublin, Republic of Ireland
Noriyoshi Takei
Affiliation:
Genetics Section, Institute of Psychiatry, London
Graham K. Murray*
Affiliation:
Genetics Section, Institute of Psychiatry, London
Edward H. Hare
Affiliation:
The Bethlem Royal and Maudsley Hospitals, London
Robin M. Murray
Affiliation:
Department of Psychological Medicine, King's College Hospital and Institute of Psychiatry, De Crespigny Park, London SE5 8AF
*
Correspondence

Abstract

We examined the relationship between the dates of births of schizophrenic patients admitted to hospitals for the first time in England and Wales between 1970 and 1979, and the occurrence of influenza epidemics between 1939 and 1960. Our results indicate that exposure to influenza epidemics between the third and seventh month of gestation is associated with schizophrenia in adult life. The hypothesis that maternal viral infection is an important cause of schizophrenia can explain many aspects of the enigmatic epidemiology of the condition.

Type
Papers
Copyright
Copyright © Royal College of Psychiatrists, 1992 

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References

Barr, C. E., Mednick, S. A. & Munk-Jorgensen, P. (1990) Exposure to influenza epidemics during gestation and adult schizophrenia: a 40–year study. Archives of General Psychiatry, 47, 869874.CrossRefGoogle ScholarPubMed
Bowler, A. E. & Torrey, E. F. (1990) Influenza and schizophrenia. Archives of General Psychiatry, 47, 876877.Google Scholar
Conrad, A. J. & Scheibel, A. B. (1987) Schizophrenia and the hippocampus: the embryological hypothesis extended. Schizophrenia Bulletin, 13, 577587.Google Scholar
Crow, T. J., Done, D. J. & Johnstone, E. C. (1991) Schizophrenia and influenza. Lancet, 338, 116118.CrossRefGoogle Scholar
Curwen, M., Dunnell, K. & Ashley, J. (1990) Hidden influenza deaths: 1989–90. Population Trends, 61, 3133.Google Scholar
Der, G., Gupta, S. & Murray, R. M. (1990) Is schizophrenia disappearing? Lancet, 335, 513516.Google Scholar
Edwards, M. J. (1986) Hyperthermia as a teratogen: a review of experimental studies and their clinical significance. Teratogenesis, Carcinogenesis, and Mutagenesis, 6, 563582.Google Scholar
Farina, A., Barry, H. & Garmezy, N. (1963) Birth order of recovered and nonrecovered schizophrenics. Archives of General Psychiatry, 9, 224228.Google Scholar
Hare, E. (1988) Temporal factors and trends, including birth seasonality and the viral hypothesis. In Handbook of Schizophrenia, vol. 3 (ed. Nasrallah, H. A.), pp. 345377. Amsterdam: Elsevier.Google Scholar
Hennessy, A. V., Davenport, F. M., Horton, R. J. M., et al (1964) Asian influenza: occurrence and recurrence, a community and family study. Military Medicine, 129, 3850.CrossRefGoogle ScholarPubMed
Kendell, R. E. & Kemp, I. W. (1989) Maternal influenza in the etiology of schizophrenia. Archives of General Psychiatry, 46, 878882.CrossRefGoogle ScholarPubMed
Kilbourne, E. D. (1987) Influenza. New York: Plenum.Google Scholar
Kreusser, K. L. & Volpe, J. L. (1984) The neurological outcome of perinatal asphyxia. In Early Brain Damage, vol. 1 (eds Alueli, C. R. & Finger, S.), pp. 151187. New York: Academic Press.CrossRefGoogle Scholar
Laing, P., Knight, J. G., Hill, J. M., et al (1989) Influenza viruses induce autoantibodies to a brain-specific 37-kDa protein in rabbit. Proceedings of the National Academy of Sciences, USA, 86, 19982002.Google Scholar
McCullagh, P. & Nelder, J. A. (1989) Generalized Linear Models (2nd edn). London: Chapman & Hall.CrossRefGoogle Scholar
Mednick, S. A., Machon, R. A., Huttenen, M. O., et al (1988) Adult schizophrenia following prenatal exposure to an influenza epidemic. Archives of General Psychiatry, 45, 189192.CrossRefGoogle Scholar
Murray, R. M., Reveley, A. M., Reveley, M. A., et al (1985) Genes and environment in schizophrenia. Genetics Aspects of Human Behaviour (eds Sakai, T. & Tsuboi, T.), pp. 6374. Tokyo: Igaku Shoin.Google Scholar
Murray, R. M., Jones, P. & O'Callaghan, E. (1991) Fetal brain development and later schizophrenia. In The Childhood Environment and Adult Disease (CIBA Foundation Symposium 156), pp. 155170. Chichester: Wiley.Google Scholar
Numerical Algorithms Group (1985) The GLIM System Release 3.77 Manual (ed. Payne, C. D.). Oxford: NAG.Google Scholar
O'Callaghan, E., Gibson, T., Colohon, H., et al (1991a) Season of birth in schizophrenia: evidence for confinement of an excess of winter births to patients without a family history of mental disorder. British Journal of Psychiatry, 158, 764769.CrossRefGoogle ScholarPubMed
O'Callaghan, E., Sham, P. C., Takei, N., et al (1991b) Schizophrenia after prenatal exposure to 1957 A2 influenza epidemic. Lancet, 337, 12481250.CrossRefGoogle ScholarPubMed
Roberts, G. (1991) Schizophrenia: a neuropathological perspective. British Journal of Psychiatry, 158, 817.CrossRefGoogle ScholarPubMed
Stuart-Harris, C. H. & Smith, J. (1982) The epidemiology of influenza – key facts and remaining problems. In Influenza Models: Prospects for Development and Use (ed. Selby, P.), pp. 89123. Lancaster: MTP Press.Google Scholar
Taylor-Papadimitriou, J. & Rozengurt, E. (1985) Interferons as regulators of cell growth and differentiation. In Interferons: Their Impact in Biology and Medicine (ed. Taylor-Papadimitriou, J.), pp. 8198. Oxford: Oxford University Press.Google Scholar
Torrey, E. F. (1980) Schizophrenia and Civilization. New York: Aronson.Google Scholar
Torrey, E. F. & Bowler, A. (1991) Geographical distribution of insanity in America: evidence for an urban factor. Schizophrenia Bulletin, 16, 591604.CrossRefGoogle Scholar
Torrey, E. F., Rawlings, R. & Waldman, I. N. (1988) Schizophrenic births and viral diseases in two states. Schizophrenia Research, 1, 7377.CrossRefGoogle ScholarPubMed
Watson, C. G., Kucala, T., Tilleskjor, C., et al (1984) Schizophrenic birth seasonality in relation to the incidence of infectious diseases and temperature extremes. Archives of General Psychiatry, 41, 8590.Google Scholar
World Health Organization (1978) Mental Disorders: Glossary and Guide to Their Classification in Accordance with the Ninth Revision of the International Classification of Diseases (ICD–9). Geneva: WHO.Google Scholar
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