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Risk for Definite Neuroleptic Malignant Syndrome

A Prospective Study in 223 Consecutive In-patients

Published online by Cambridge University Press:  02 January 2018

Haggai Hermesh ,
Dov Aizenberg ,
Abraham Weizman ,
Margo Lapidot ,
Catherina Mayor  and
Hanan Munitz
Haggai Hermesh*
Affiliation:
Geha Psychiatric Hospital, Beilinson Medical Center, Petah Tikva and Sackler School of Medicine, Tel Aviv University, Israel
Dov Aizenberg
Affiliation:
Geha Psychiatric Hospital, Beilinson Medical Center, Petah Tikva and Sackler School of Medicine, Tel Aviv University, Israel
Abraham Weizman
Affiliation:
Geha Psychiatric Hospital, Beilinson Medical Center, Petah Tikva and Sackler School of Medicine, Tel Aviv University, Israel
Margo Lapidot
Affiliation:
Geha Psychiatric Hospital, Beilinson Medical Center, Petah Tikva and Sackler School of Medicine, Tel Aviv University, Israel
Catherina Mayor
Affiliation:
Geha Psychiatric Hospital, Beilinson Medical Center, Petah Tikva and Sackler School of Medicine, Tel Aviv University, Israel
Hanan Munitz
Affiliation:
Geha Psychiatric Hospital, Beilinson Medical Center, Petah Tikva and Sackler School of Medicine, Tel Aviv University, Israel
*
∗Geha Psychiatric Hospital, PO Box 102, Petah Tikva 49 100, Israel
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Abstract

The occurrence of neuroleptic malignant syndrome (NMS) was studied prospectively in two series of consecutive psychiatric in-patients (n = 223). The first group (n = 120) suffered from schizophrenia and was treated only with haloperidol. The second group (n=103) was treated with diverse neuroleptics. All patients were on a single antipsychotic agent with no anticholinergic drug as prophylaxis. The incidence of full NMS per admission and first neuroleptic exposure was 5/223 (2.2%). Patients with bipolar affective disorder and those treated with injections were significantly over-represented in the NMS group.

Type
Brief Reports
Information
The British Journal of Psychiatry , Volume 161 , Issue 2 , August 1992 , pp. 254 - 257
Copyright
Copyright © 1992 The Royal College of Psychiatrists 

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