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Positive and Negative Symptoms

Relation to Familial Transmission of Schizophrenia

Published online by Cambridge University Press:  02 January 2018

Miron Baron ,
Rhoda S. Gruen  and
Joan M. Romo-Gruen
Miron Baron*
Affiliation:
Columbia University College of Physicians and Surgeons, and Director of Psychogenetics, Department of Medical Genetics, New York State Psychiatric Institute
Rhoda S. Gruen
Affiliation:
Columbia University College of Physicians and Surgeons, and Research Scientist, New York State Psychiatric Institute
Joan M. Romo-Gruen
Affiliation:
New York State Psychiatric Institute, USA
*
∗New York State Psychiatric Institute, 722 West 168th Street, New York, NY 10032, USA
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Abstract

The authors assessed the relevance of clinical symptoms to genetic research in schizophrenia in the nuclear families of 65 chronic schizophrenic probands. The morbidity risk for schizophrenia and schizotypal personality (a ‘spectrum’ disorder) was markedly reduced in first-degree relatives of probands with predominant negative symptoms, as compared with relatives of probands with other symptom patterns. The data support the notion that negative-symptom schizophrenia has an attenuated genetic component.

Type
Papers
Information
The British Journal of Psychiatry , Volume 161 , Issue 5 , November 1992 , pp. 610 - 614
Copyright
Copyright © 1992 The Royal College of Psychiatrists 

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References

American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM–III). Washington, DC: APA.Google Scholar
Andreasen, N. C. (1981) Scale for the Assessment of Negative Symptoms (SANS). Iowa City, IA: University of Iowa Press.Google Scholar
Andreasen, N. C. & Olsen, S. (1982) Negative versus positive schizophrenia: definition and validation. Archives of General Psychiatry, 39, 789–794.CrossRefGoogle Scholar
Andreasen, N. C., Flaum, M., Swayze, V. W., et al (1990) Positive and negative symptoms in schizophrenia: a critical reappraisal. Archives of General Psychiatry, 47, 615–621.CrossRefGoogle ScholarPubMed
Baron, M. (1992) Psychiatric disorders. In Genetic Analysis of Human Complex Disease (eds A. Chakravarti, E. Lander & J. Witkowski). New York: Cold Spring Harbor Laboratory Press (in press).Google Scholar
Baron, M. & Gruen, R. (1980) The Schedule for Interviewing Borderlines (SIB). New York: New York State Psychiatric Institute.Google Scholar
Baron, M., Asnis, L. & Gruen, R. (1981) The Schedule for Schizotypal Personalities (SSP): a diagnostic interview for schizotypal features. Psychiatry Research, 4, 213–228.CrossRefGoogle ScholarPubMed
Baron, M., Gruen, R., Asnis, L., et al (1983) Familial relatedness between schizophrenia and schizotypal states. American Journal of Psychiatry, 140, 1437–1442.Google ScholarPubMed
Baron, M., Gruen, R., Rainer, J. D., et al (1985a) A family study of schizophrenia and normal control probands: implications for the spectrum concept of schizophrenia. American Journal of Psychiatry, 142, 447–455.Google ScholarPubMed
Baron, M., Gruen, R., Kane, J., et al (1985b) Modern research criteria and the genetics of schizophrenia. American Journal of Psychiatry, 142, 697–701.Google ScholarPubMed
Baron, M., Endicott, J. & Ott, J. (1990) Genetic linkage in mental illness: limitations and prospects. British Journal of Psychiatry, 157, 645–655.CrossRefGoogle ScholarPubMed
Crow, T. J. (1980) Molecular pathology of schizophrenia: more than one disease process. British Medical Journal, 28, 66–68.CrossRefGoogle Scholar
Crow, T. J. (1985) The two-syndrome concept: origins and current status. Schizophrenia Bulletin, 11, 471–486.CrossRefGoogle ScholarPubMed
Dworkin, R. H. & Lenzenweger, M. F. (1984) Symptoms and the genetics of schizophrenia: implications for diagnosis. American Journal of Psychiatry, 141, 1541–1546.Google ScholarPubMed
Dworkin, R. H., Lenzenweger, M. F. & Moldin, S. O., et al (1987) Genetics and the phenomenology of schizophrenia. In Positive and Negative Symptoms in Psychosis (eds P. O. Harvey & E. F. Walker), pp. 258–288. Hillsdale: Laurence Erlbaum Associates.Google Scholar
Dworkin, R. H., Lenzenweger, M. F. & Moldin, S. O., et al (1988) A multi-dimensional approach to the genetics of schizophrenia. American Journal of Psychiatry, 154, 1077–1083.Google Scholar
Endicott, J. & Spitzer, R. L. (1978) A diagnostic interview: the Schedule for Affective Disorders and Schizophrenia. Archives of General Psychiatry, 35, 837–844.CrossRefGoogle ScholarPubMed
Farmer, A. E., Jackson, R. & Storey, P. (1985) Classifying schizophrenia. Lancet, i, 33.Google Scholar
Johnstone, E. C., Owens, D. G. C., Gold, A., et al (1981) Institutionalisation and the defects of schizophrenia. British Journal of Psychiatry, 139, 195–203.CrossRefGoogle ScholarPubMed
Kendler, K. S. (1986) A twin study of mortality in schizophrenia and neurosis. Archives of General Psychiatry, 43, 643–649.CrossRefGoogle ScholarPubMed
Kendler, K. S. & Gruenberg, A. M. (1982) Genetic relationship between paranoid personality disorder and the ‘schizophrenic spectrum’ disorders. American Journal of Psychiatry, 139, 1185–1186.Google ScholarPubMed
Kendler, K. S. & Strauss, J. S. (1981) An independent analysis of the Copenhagen sample of the Danish adoption study of schizophrenia. Archives of General Psychiatry, 38, 982–984.CrossRefGoogle ScholarPubMed
Lenzenweger, M. F., Dworkin, R. H. & Wethington, E. (1989) Models of positive and negative symptoms in schizophrenia: an empirical evaluation of latent structures. Journal of Abnormal Psychology, 1, 62–70.CrossRefGoogle Scholar
Lewis, S. W., Reveley, A. M., Reveley, M. A., et al (1987) The familial/sporadic distinction as a strategy in schizophrenia research. British Journal of Psychiatry, 151, 306–313.CrossRefGoogle ScholarPubMed
Lindenmayer, J. P., Kay, S. R. & Opler, L. (1985) Positive and negative subtypes in acute schizophrenia. Comprehensive Psychiatry, 25, 455–464.CrossRefGoogle Scholar
Marks, R. C. & Luchins, D. J. (1990) Relationship between brain imaging findings in schizophrenia and psychopathology: a review of the literature relating to positive and negative symptoms. In Modern Problems of Pharmacopsychiatry: Positive and Negative Symptoms and Syndromes (ed. Andreasen, N. C.), pp. 24, 89–123. Basel, Switzerland: S. Karger.Google Scholar
McGuffin, P., Farmer, A. & Gottesman, I. I. (1987) Is there really a split in schizophrenia? British Journal of Psychiatry, 150, 581–592.CrossRefGoogle ScholarPubMed
Nasrallah, H. A., Charles, G. T., McCalley-Whitters, M., et al (1982) Cerebral ventricular enlargement in subtypes of chronic schizophrenia. Archives of General Psychiatry, 39, 774–777.CrossRefGoogle ScholarPubMed
Owen, D. G. C., Johnstone, E. C., Crow, T. J., et al (1985) Lateral ventricular size in schizophrenia: relationship to the disease process and its clinical manifestations. Psychological Medicine, 15, 24–41.Google Scholar
Pearlson, G. D., Garbacz, D. J., Moberg, P. J., et al (1984) Symptomatic, familial, perinatal, and social correlates of CT changes in schizophrenics and bipolars. Journal of Nervous and Mental Disease, 173, 42–50.CrossRefGoogle Scholar
Quitkin, F. M., Rifkin, A., Tsuang, M. T., et al (1980) Can schizophrenia with premorbid asociality be genetically distinguished from the other forms of schizophrenia? Psychiatry Research, 2, 99–105.CrossRefGoogle ScholarPubMed
Reveley, A. M., Reveley, M. A., Clifford, C. A., et al (1982) Cerebral ventricular size in twins discordant for schizophrenia. Lancet, i, 540–541.CrossRefGoogle Scholar
Reveley, A. M. & Murray, R. M. (1984) Cerbral ventricular enlargement in nongenetic schizophrenia: a controlled twin study. British Journal of Psychiatry, 144, 89–93.CrossRefGoogle Scholar
Spitzer, R. L., Endicott, J. & Robins, E. (1978) Research Diagnostic Criteria: rationale and reliability. Archives of General Psychiatry, 35, 773–782.CrossRefGoogle ScholarPubMed
Turner, S., Toone, B. & Brett-Jones, J. (1986) Computerized tomography and changes in early schizophrenia – preliminary findings. Psychological Medicine, 16, 219–225.CrossRefGoogle ScholarPubMed
Williams, A. O., Reveley, M. A., Kolakowska, T., et al (1985) Schizophrenia with good and poor outcome: cerebral ventricular size and its clinical significance. British Journal of Psychiatry, 146, 239–246.CrossRefGoogle ScholarPubMed
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