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Serum Creatine Phosphokinase Elevations in Patients with Tardive Dyskinesia

Published online by Cambridge University Press:  02 January 2018

Michael F. Egan ,
Anissa Abi Dargham ,
Darrelll G. Kirch  and
Richard Jed Wyatt
Michael F. Egan*
Affiliation:
Neuropsychiatry Branch, NIMH Neuroscience Research Center at St Elizabeth's, 2700 M. L. King Junior Avenue, Washington, DC 20032, USA
Anissa Abi Dargham
Affiliation:
Clinical Brain Disorders Branch, Washington, USA
Darrelll G. Kirch
Affiliation:
Division of Clinical Research, Rockville, USA
Richard Jed Wyatt
Affiliation:
Neuropsychiatry Branch, Washington, USA
*
∗Correspondence
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Abstract

We describe a case of marked increases in serum creatine phosphokinase (CPK) associated with a dramatic exacerbation of tardive dyskinesia (TD). Chart review of eight additional patients with severe TD revealed three cases with mild CPK elevations. These cases suggest that TD, especially when accompanied by dystonia, may be associated with pathology of striated muscle.

Type
Brief Reports
Information
The British Journal of Psychiatry , Volume 162 , Issue 4 , April 1993 , pp. 551 - 553
Copyright
Copyright © Royal College of Psychiatrists, 1993 

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References

Bendich, A. & Machlin, L. (1988) Safety of oral intake of vitamin E. American Journal of Clinical Nutrition, 48, 612–619.CrossRefGoogle ScholarPubMed
Cavanaugh, J. J. & Finlayson, R. E. (1984) Rhabdomyolysis due to acute dystonic reaction to antipsychotic drugs. Journal of Clinical Psychiatry, 45, 356–357.Google Scholar
Foster, F. G. & Kupfer, D. J. (1973) Psychomotor activity and serum creatine phosphokinase activity. Archives of General Psychiatry, 29, 752–758.Google Scholar
Lieberman, J. A. & Reife, R. (1989) Spastic dysphonia and denervation signs in a young man with tardive dyskinesia. British Journal of Psychiatry, 154, 105–109.Google Scholar
Lui, W. Y. (1979) Phenothiazine–induced dystonia associated with an increase in serum creatine phosphokinase. Archives of Disease in Childhood, 54, 150–151.CrossRefGoogle ScholarPubMed
Malas, K. L. & van Kammen, D. P. (1982) Markedly elevated creatine phosphokinase levels after neuroleptic withdrawal. American Journal of Psychiatry, 139, 231–232.Google Scholar
Meltzer, H. Y. & Moline, R. (1970) Plasma enzymatic activity after exercise: study of psychiatric patients and their relatives. Archives of General Psychiatry, 22, 390–397.Google Scholar
Meltzer, H. Y. (1976) Serum phosphokinase in schizophrenia. American Journal of Psychiatry, 133, 192–197.Google Scholar
Pearlman, C., Wheadon, D. & Epstein, S. (1988) Creatine kinase elevation after neuroleptic treatment. American Journal of Psychiatry, 145, 1018–1019.Google Scholar
Ravi, S. D., Broge, G. F. & Roach, F. L. (1982) Neuroleptics, laryngeal–pharyngeal dystonia and acute renal failure. Journal of Clinical Psychiatry, 43, 300.Google Scholar
Wojcik, J. D., Gelenberg, A. J., Labrie, R. A., et al (1980) Prevalence of tardive dyskinesia in an outpatient population. Comprehensive Psychiatry, 21, 370–380.Google Scholar
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