Hostname: page-component-7c8c6479df-r7xzm Total loading time: 0 Render date: 2024-03-28T14:39:39.308Z Has data issue: false hasContentIssue false

Concurrent Agranulocytosis and Hepatitis Secondary to Clomipramine Therapy

Published online by Cambridge University Press:  02 January 2018

Christopher P. Alderman*
Affiliation:
Pharmacy Department, Repatriation General Hospital, Daw Park, South Australia 5041
Michelle M. Atchison
Affiliation:
The Queen Elizabeth Hospital, Woodville, South Australia
Janet I. McNeece
Affiliation:
Drug and Therapeutics Information Service, Repatriation General Hospital, South Australia
*
Correspondence

Abstract

A 67-year-old man developed concurrent severe agranulocytosis and elevation of hepatic transaminases as a result of treatment with clomipramine. Although such adverse drug reactions can be considered rare events, the potentially serious nature of these reactions vindicate the routine monitoring of blood picture, and liver function tests, after initiation of treatment with tricyclic antidepressants.

Type
Brief Reports
Copyright
Copyright © Royal College of Psychiatrists, 1993 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Albertino, R. S. & Penders, T. M. (1978) Agranulocytosis associated with tricyclics. Journal of Clinical Psychiatry, 39, 483485.Google Scholar
American Psychiatric Association (1967) Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised) (DSM-III-R). Washington, DC: APA.Google Scholar
Australian Adverse Drug Reactions Advisory Committee (1980) Mianserin: a possible cause of neutropenia and agranulocytosis. Medical Journal of Australia, ii, 673.Google Scholar
Curson, D. A. & Hale, A. S. (1979) Mianserin and agranulocytosis. British Medical Journal, i, 378379.Google Scholar
Doery, J. C. G., Meredith, H. A. & Mashford, M. L. (1982) Agranulocytosis associated with dothiepin. Medical Journal of Australia, ii, 389390.Google Scholar
Draper, B. M. & Manoharan, A. (1987) Neutropenia with crossintolerance between two tricyclic antidepressant agents. Medical Journal of Australia, 146, 452453.CrossRefGoogle ScholarPubMed
Gravenor, D. S., LeClerc, J. R., Blake, G. (1986) Tricyclic antidepressant agranulocytosis. Canadian Journal of Psychiatry, 31, 661.Google Scholar
Hardin, T. C. & Conrath, F. C. (1982) Desipramine-induced agranulocytosis. A case report. Drug Intelligence and Clinical Pharmacy, 16, 6263.CrossRefGoogle ScholarPubMed
Inman, W. H. W. (1988) Blood disorders and suicide in patients taking mianserin or amitriptyline. Lancet, ii, 9092.CrossRefGoogle Scholar
Larrey, D., Rueff, B., Pessayre, D., et al (1986) Cross hepatotoxicity between tricyclic antidepressants. Gut, 27, 726727.Google Scholar
Larrey, D., Rueff, B., Pessayre, D., Berson, A., Habersetzer, F., et al (1989) Genetic predisposition to drug hepatotoxicity: role in hepatitis caused by amineptine, a tricyclic antidepressant. Hepatology, 10, 168173.Google Scholar
Morrow, P. L., Hardin, N. J. & Bonadies, J. (1989) Hypersensitivity myocarditis and hepatitis associated with imipramine and its metabolite desipramine. Journal of Forensic Science, 34, 10161020.Google Scholar
Richelson, E. (1983) Are receptor studies useful for clinical practice? Journal of Clinical Psychiatry, 44, 49.Google Scholar
Shaefer, M. S., Edmunds, A. L., Markin, R. S., et al (1990) Hepatic failure associated with imipramine therapy. Pharmacotherapy, 10, 6669.CrossRefGoogle ScholarPubMed
Zimmerman, H. J. & Ishak, K. G. (1987) The hepatic injury of monoamine oxidase inhibitors. Journal of Clinical Psychopharmacology, 7, 211213.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.