Hostname: page-component-8448b6f56d-mp689 Total loading time: 0 Render date: 2024-04-23T17:28:44.529Z Has data issue: false hasContentIssue false
  • English
  • Français

An Association Between Low Levels of 5-HIAA and HVA in Cerebrospinal Fluid and Early Mortality in a Diagnostically Mixed Psychiatric Sample

Published online by Cambridge University Press:  02 January 2018

William O. Faustman ,
David L. Ringo  and
Kym F. Faull
William O. Faustman*
Affiliation:
Stanford/VA Mental Health Clinical Research Center Stanford University School of Medicine
David L. Ringo
Affiliation:
Stanford University School of Medicine
Kym F. Faull
Affiliation:
The Neuropsychiatric Institute and Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles
*
∗Stanford/VA Mental Health Clinical Research Center, Unit 4C2, Department of Veterans Affairs Medical Center, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
Get access Rights & Permissions [Opens in a new window]

Abstract

We followed up a sample of psychiatric patients (diagnoses predominantly schizophrenia and depression) who had participated in in-patient studies of their CSF over the past 15 years. The status of 73 former patients was confirmed, of whom 12 had died. Seven of these patients died at age ⩽40, largely of suicide, homicide, or accidental causes. These seven patients had significantly lower CSF 5-HIAA and HVA than living control patients. There were significant direct correlations between age at death and both CSF 5-HIAA and HVA in the deceased patients. The results offer support for CSF monoamine metabolites relating to early death in a diagnostically diverse sample of psychiatric patients.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 163 , Issue 4 , October 1993 , pp. 519 - 521
Copyright
Copyright © Royal College of Psychiatrists, 1993 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Allebeck, P. & Wistedt, B. (1986) Mortality in schizophrenia: a ten-year follow-up based on the Stockholm County inpatient register. Archives of General Psychiatry, 43, 650–653.Google Scholar
Anderson, C., Connelly, J., Johnstone, E. C., et al (1991) Disabilities and circumstances of schizophrenic patients. V. Cause of death. British Journal of Psychiatry, 159 (suppl. 13), 30–33.CrossRefGoogle Scholar
Banki, C. M. & Molnar, G. (1981) Cerebrospinal fluid 5-hydroxyindoleacetic acid as an index of central serotonergic processes. Psychiatry Research, 5, 23–32.Google Scholar
Berger, P. A., Faull, K. F., Kilkowski, J., et al (1980) CSF monoamine metabolites in depression and schizophrenia. American Journal of Psychiatry, 137, 174–180.Google Scholar
Brown, G. L. & Linnoila, M. I. (1990) CSF serotonin metabolite (5-HIAA) studies in depression, impulsivity, and violence. Journal of Clinical Psychiatry (suppl.), 51, 31–41.Google Scholar
Endicott, J. & Spitzer, R. L. (1978) A diagnostic interview: the Schedule for Affective Disorder and Schizophrenia (SADS). Archives of General Psychiatry, 35, 837–844.CrossRefGoogle Scholar
Faull, K. F., Anderson, P. J. & Barchas, J. D. (1979) Selected ion monitoring assay for biogenic amine metabolites and probenecid in human cerebrospinal fluid. Journal of Chromatography (Biomedical Applications), 163, 337–349.Google Scholar
Jibson, M.D., Faull, K. F. & Csernansky, J. G. (1990) Intercorrelation of CSF HVA, 5-HIAA, and MHPG before and after probenecid administration. Biological Psychiatry, 28, 595–602.Google Scholar
Losonczy, M. F., Davidson, M. & Davis, K. L. (1987) The dopamine hypothesis of schizophrenia. In Psychopharmacology: the Third Generation of Progress (ed. Meltzer, H. Y.), pp. 715–726. New York: Raven Press.Google Scholar
Meltzer, H. Y. & Lowy, M. T. (1987) The serotonin hypothesis of depression. In Psychopharmacology: the Third Generation of Progress (ed. Meltzer, H. Y.), pp. 513–526. New York: Raven Press.Google Scholar
Roy, A., De Jong, J. & Linnoila, M. (1989) Cerebrospinal fluid monoamine metabolites and suicidal behavior in depressed patients. Archives of General Psychiatry, 46, 609–612.CrossRefGoogle ScholarPubMed
Spitzer, R. L., Endicott, J. & Robins, E. (1978) Research diagnostic criteria: rationale and reliability. Archives of General Psychiatry, 35, 773–782.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.