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Evidence Against a Genetic Relationship between Tourette's Syndrome and Anxiety, Depression, Panic and Phobic Disorders

Published online by Cambridge University Press:  02 January 2018

David L. Pauls*
Affiliation:
Child Study Center, Yale University School of Medicine, 230 South Frontage Road, New Haven, CT 06510, USA
James F. Leckman
Affiliation:
Child Study Center, Yale University School of Medicine, 230 South Frontage Road, New Haven, CT 06510, USA
Donald J. Cohen
Affiliation:
Child Study Center, Yale University School of Medicine, 230 South Frontage Road, New Haven, CT 06510, USA
*
Correspondence

Abstract

Analyses were undertaken to examine whether a wide range of psychiatric disorders, including anxiety, affective, substance abuse and psychotic disorders, represent variant manifestations of Tourette's syndrome (TS). Previous studies have suggested that chronic tics (CT) and obsessive-compulsive disorder (OCD) are variant expressions of TS since both CT and OCD are elevated among relatives of TS probands. In the current study, no other psychiatric disorder was significantly elevated among the relatives who did not have TS, CT or OCD when compared with a control sample. These findings are not consistent with the hypothesis that a wide range of psychiatric and behavioural disorders are variant expressions of TS.

Type
Papers
Copyright
Copyright © 1994 The Royal College of Psychiatrists 

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References

American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM–III). Washington DC: APA Press.Google Scholar
Berkson, J. (1946) Limitations of the application of fourfold table analysis to hospital data. Biometrics, 2, 4751.10.2307/3002000CrossRefGoogle ScholarPubMed
Cohen, D. J., Bruun, R. & Leckman, J. F., (eds) (1988) Tourette Syndrome and Tic Disorders: Clinical Understanding and Treatment. New York: John Wiley.Google Scholar
Comings, D. E. & Comings, B. G. (1985) Tourette syndrome: clinical and psychological aspects of 250 cases. American Journal of Human Genetics, 37, 435450.Google ScholarPubMed
Comings, D. E. & Comings, B. G. (1987a) A controlled study of Tourette syndrome. I. Attention deficit disorder, learning disorders and school problems. American Journal of Human Genetics, 41, 701741.Google ScholarPubMed
Comings, D. E. & Comings, B. G. (1987b) A controlled study of Tourette syndrome. II. Conduct. American Journal of Human Genetics, 41, 742760.Google ScholarPubMed
Comings, D. E. & Comings, B. G. (1987c) A controlled study of Tourette syndrome. III. Phobias and panic attacks. American Journal of Human Genetics, 41, 761781.Google ScholarPubMed
Comings, D. E. & Comings, B. G. (1987d) A controlled study of Tourette syndrome. IV. Obsessions, compulsions and schizoid behaviors. American Journal of Human Genetics, 41, 782803.Google ScholarPubMed
Comings, D. E. & Comings, B. G. (1987e) A controlled study of Tourette syndrome. V. Depression and mania. American Journal of Human Genetics, 41, 804821.Google Scholar
Comings, D. E. & Comings, B. G. (1987f) A controlled study of Tourette syndrome. VI. Early development, sleep problems, allergies and handedness. American Journal of Human Genetics, 41, 823838.Google Scholar
Comings, D. E. & Comings, B. G. (1990a) A controlled family history study of Tourette syndrome: I. Attention deficit disorder, learning disorders and school problems. Journal of Clinical Psychiatry, 51, 275280.Google Scholar
Comings, D. E. & Comings, B. G. (1990b) A controlled family history study of Tourette syndrome: I. Alcoholism, drug abuse and obesity. Journal of Clinical Psychiatry, 51, 281287.Google Scholar
Comings, D. E. & Comings, B. G. (1990c) A controlled family history study of Tourette syndrome: III. Affective and other disorders. Journal of Clinical Psychiatry, 51, 288291.Google ScholarPubMed
Eapen, N., Pauls, D. L. & Robertson, M. M. (1993) Evidence for autosomal dominant transmission in Gilles de la Tourette syndrome - United Kingdom Cohort Study. British Journal of Psychiatry, 162, 593596.10.1192/bjp.162.5.593CrossRefGoogle ScholarPubMed
Fyer, A. J., Mannuzza, S., Gallops, M. S., et al (1990) Familial transmission of simple phobias and fears: a preliminary report. Archives of General Psychiatry, 47, 252256.10.1001/archpsyc.1990.01810150052009CrossRefGoogle Scholar
Kidd, K. K., Prusoff, B. A. & Cohen, D. J. (1980) The familial pattern of Tourette syndrome. Archives of General Psychiatry, 37, 13361339.10.1001/archpsyc.1980.01780250022001Google Scholar
Leckman, J. F., Sholomskas, D., Thompson, W. D., et al (1982) Best estimate of lifetime psychiatric diagnoses: a methodological study. Archives of General Psychiatry, 39, 879883.10.1001/archpsyc.1982.04290080001001Google Scholar
Noyes, R. Jr, Clarkson, C., Crowe, R. R., et al (1987) A family study of generalized anxiety disorder. American Journal of Psychiatry, 144, 10191024.Google ScholarPubMed
Pauls, D. L., Cohen, D. J., Heimbuch, R., et al (1981) Familial pattern and transmission of Gilles de la Tourette syndrome and multiple tics. Archives of General Psychiatry, 38, 10911093.10.1001/archpsyc.1981.01780350025002Google Scholar
Pauls, D. L., & Hurst, C. R. (1981) Schedule for Tourette's Syndrome and Other Behavioral Syndromes. New Haven, CT: Yale University Child Study Center.Google Scholar
Pauls, D. L., Kruger, S. D., Leckman, J. F., et al (1984) The risk of Tourette syndrome (TS) and chronic multiple tics (CMT) among relatives of TS patients: obtained by direct interview. Journal of the American Academy of Child Psychiatry, 23, 134137.10.1097/00004583-198403000-00003Google Scholar
Pauls, D. L., & Leckman, J. F. (1986) The inheritance of Gilles de la Tourette's syndrome and associated behaviors: evidence for autosomal dominant transmission. New England Journal of Medicine, 315, 993997.10.1056/NEJM198610163151604Google Scholar
Pauls, D. L., Hurst, C. R., Kidd, K. K., et al (1986a) Tourette syndrome and attention deficit disorder: evidence against a genetic relationship. Archives of General Psychiatry, 43, 11771179.10.1001/archpsyc.1986.01800120063012CrossRefGoogle ScholarPubMed
Pauls, D. L., Towbin, K. E., Leckman, J. F., et al (1986b) Gilles de la Tourette syndrome and obsessive compulsive disorder: evidence supporting an etiological relationship. Archives of General Psychiatry, 43, 11801182.10.1001/archpsyc.1986.01800120066013Google Scholar
Pauls, D. L., Raymond, C. L., Leckman, J. F., et al (1991) A family study of Tourette's syndrome. American Journal of Human Genetics, 48, 154163.Google Scholar
Pauls, D. L., Leckman, J. F. & Cohen, D. J. (1993) The familial relationship between Gilles de la Tourette's syndrome, attention deficit disorder, learning disabilities, speech disorders and stuttering. Journal of the American Academy of Child and Adolescent Psychiatry, 32, 10441050.10.1097/00004583-199309000-00025Google Scholar
Puig-Antich, J., Orvaschel, H., Tabrizi, M. A., et al (1980) The Schedule for Affective Disorders and Schizophrenia for Schoolage Children - Epidemiologic Version (Kiddie-SADS-E) (3rd edn). New York and New Haven, CT: New York State Psychiatric Institute and Yale University School of Medicine.Google Scholar
Rasmussen, S. & Eisen, J. L. (1991) Phenomenology of OCD: clinical subtypes, heterogeneity and coexistence. In The Psychobiology of Obsessive–Compulsive Disorder (eds Zohar, J., Insel, T. & Rasmussen, S.), pp. 1343. New York: Springer Publishing Company.Google Scholar
Robertson, M. M., Trimble, M. R. & Lees, A. J. (1988) The psychopathology of the Gilles de la Tourette: a phenomenological analysis. British Journal of Psychiatry, 152, 383390.10.1192/bjp.152.3.383Google Scholar
Robins, L. N., Helzer, J. E., Croughman, J., et al (1981) National Institute of Mental Health Diagnostic Interview Schedule. Archives of General Psychiatry, 38, 381389.10.1001/archpsyc.1981.01780290015001CrossRefGoogle ScholarPubMed
Institute, SAS (1985) Statistical Analysis System. Cary, NC: SAS Institute.Google Scholar
Shapiro, A. K., Shapiro, E. S., Bruun, R. D., et al (1978) Gilles de la Tourette's Syndrome. New York: Raven Press.Google Scholar
Shapiro, A. K., Shapiro, E. S., Young, J. G., et al (1988) Gilles de la Tourette Syndrome (2nd edn). New York: Raven Press.Google Scholar
Thompson, D. & Weissman, M. M. (1979) Quantifying lifetime risk of psychiatric disorder. Journal of Psychiatry Research, 15, 291303.Google Scholar
Tsuang, M. T. (1991) Morbidity risks of schizophrenia and affective disorder among first-degree relatives of patients with schizoaffective disorders. British Journal of Psychiatry, 158, 165170.10.1192/bjp.158.2.165CrossRefGoogle ScholarPubMed
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