Hostname: page-component-8448b6f56d-tj2md Total loading time: 0 Render date: 2024-04-16T08:09:08.367Z Has data issue: false hasContentIssue false
  • English
  • Français

Changes of Plasma Concentrations of Interleukin-1α and Interleukin-6 with Neuroleptic Treatment for Schizophrenia

Published online by Cambridge University Press:  02 January 2018

Hai-Min Xu ,
Jun Wei  and
Gwynneth P. Hemmings
Hai-Min Xu
Affiliation:
Institute of Biological Psychiatry, Schizophrenia Association of Great Britain
Jun Wei*
Affiliation:
Institute of Biological Psychiatry, Schizophrenia Association of Great Britain
Gwynneth P. Hemmings
Affiliation:
Schizophrenia Association of Great Britain
*
∗Institute of Biological Psychiatry, Wellcome Building, Deiniol Road, Bangor, Gwynedd LL57 2UW
Get access Rights & Permissions [Opens in a new window]

Abstract

A significant difference of plasma interleukin (IL)-1α concentration was found between schizophrenic patients taking neuroleptic drugs (n = 38) and those not taking them (n = 14; P < 0.02); Kruskal-Wallis analysis revealed a significant difference of plasma IL-6 concentration among the patients taking neuroleptic drugs, those not taking them, and healthy control subjects (H = 7.1, d.f. = 2, P < 0.05); also, there was a significant difference of plasma IL-6 concentration between the patients taking neuroleptic drugs (n = 32) and those not taking them (n = 13; P < 0.01). No significant differences were found between the three groups in the concentrations of IL-1β, IL-2 and tumour necrosis factor(TNF)-α. The present results suggest that neuroleptic treatment may change IL-1α and IL-6 production in schizophrenic patients.

Type
Short Papers
Information
The British Journal of Psychiatry , Volume 164 , Issue 2 , February 1994 , pp. 251 - 253
Copyright
Copyright © 1994 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Andrews, R. C. R. (1990) Unification of the findings in schizophrenia by reference to the effects of gestational zinc deficiency. Medical Hypotheses, 31, 141–153.10.1016/0306-9877(90)90010-CGoogle Scholar
Arai, K., Lee, F., Miyajima, A., et al (1990) Cytokines: coordinators of immune and inflammatory responses. Annual Reviews of Biochemistry, 59, 783–836.10.1146/annurev.bi.59.070190.004031Google Scholar
Banks, W. A. & Kastin, A. J. (1991) Blood to brain transport of interleukin links the immune and central nervous system. Life Sciences, 48, 117–121.10.1016/0024-3205(91)90385-OCrossRefGoogle Scholar
Hama, T., Kushima, Y., Miyamoto, M., et al (1991) Interleukin-6 improves the survival of mesencephalic catecholaminergic and septal cholinergic neurons from postnatal, two-week-old rats in cultures. Neuroscience, 40, 445–452.10.1016/0306-4522(91)90132-8CrossRefGoogle ScholarPubMed
Selmaj, K. W., Farooq, M., Norton, W. T., et al (1990) Proliferation of astrocytes in vitro in response to cytokines: a primary role for tumour necrosis factor. Journal of Immunology, 144, 129–135.CrossRefGoogle Scholar
Shintani, F., Kanba, S., Maruo, N., et al (1991) Serum interleukin-6 in schizophrenic patients. Life Sciences, 49, 661–664.10.1016/0024-3205(91)90112-OCrossRefGoogle ScholarPubMed
Slater, E. & Roth, M. (1972) Schizophrenia. In Mayer-Gross Slater and Roth's Clinical Psychiatry (3rd edn), pp. 237–341. London: Bailliere, Tindall & Cassell.Google Scholar
Smith, R. S. (1991) Is schizophrenia caused by excessive production of interleukin-2 and interleukin-2 receptors by gastrointestinal lymphocytes? Medical Hypotheses, 34, 225–229.10.1016/0306-9877(91)90215-KGoogle Scholar
Van Snick, J. (1990) Interleukin-6: an overview. Annual Reviews of Immunology, 8, 253–278.10.1146/annurev.iy.08.040190.001345Google Scholar
Villemain, F., Chatenoud, L., Guillibert, E., et al (1987) Decreased production of interleukin 2 in schizophrenia. Annals of the New York Academy of Sciences, 496, 669–675.10.1111/j.1749-6632.1987.tb35828.xCrossRefGoogle ScholarPubMed
Wei, J., Ramchand, C. N. & Hemmings, G. P. (1992a) Studies on concentrations of NA and HVA and activity of DBH in the serum from schizophrenic patients, first-degree relatives and normal subjects. Schizophrenia Research, 8, 103–110.10.1016/0920-9964(92)90025-ZCrossRefGoogle ScholarPubMed
Wei, J., Xu, H-M., Davies, J. I., et al (1992b) Increase of plasma IL-6 concentration with age in healthy subjects. Life Sciences, 51, 1953–1956.10.1016/0024-3205(92)90112-3CrossRefGoogle ScholarPubMed
Submit a response

eLetters

No eLetters have been published for this article.